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Linzess Side Effects

Linzess is a prescription medication used in adults to treat irritable bowel syndrome with constipation and chronic idiopathic constipation. "Idiopathic" means the cause of the constipation is unknown. It is not known if Linzess is safe and effective in children less than 18 years of age. Linzess works by increasing the secretion of chloride and water in the intestines, which can soften stools and stimulate bowel movements.

Important information

  • You should not use Linzess if you have a blockage in your intestines.
  • Linzess should not be given to children younger than 6 years old. Linaclotide can cause severe dehydration in a child.
  • Take Linzess in the morning on an empty stomach, 30 minutes before breakfast. Do not crush, chew, break, or open a capsule. Swallow it whole.
  • Stop using Linzess and call your doctor at once if you have severe diarrhea, stomach pain, or black, bloody, or tarry stools.

Side Effects

Diarrhea, bloating, gas, or stomach pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Also, stop taking this medication and tell your doctor right away if you have any serious side effects, including severe diarrhea.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling, severe dizziness, trouble breathing.

Some side effects of linzess may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • chills
  • ear congestion
  • excess air or gas in the stomach or intestines
  • headache
  • loss of voice

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

What happens if I miss a dose?

Skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose. Before you take Linzess, make sure to tell your doctor about your medical conditions, including if you are:

  • Pregnant or plan to become pregnant. It is not known if Linzess will harm your unborn baby.
  • Breastfeeding or plan to breastfeed. It is not known if Linzess passes into your breast milk.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Before taking linzess, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of stomach blockage. Before having surgery, tell your doctor or dentist about all the products you use. During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.