ER-positive cancers are the most common
ER-positive cancers are the most common breast cancers. ER-positive cancers have receptors for estrogen and so are fueled by that hormone; they grow in response to the presence of estrogen.
ER-positive cancers still produce EDB-FN, which attracts Gd3N@C80. So the images produced by the MRI will show highlights around the breast cancer tumor.
The idea was that, because more aggressive breast cancers produce more EDB-FN, the ZD2 will attach more gadolinium to the tumors, which will cause them to show more brightly on the MRI than less aggressive cancers.
Did that hold true?