Dr. Ralph Deberardinis is a pediatrician practicing in Philadelphia, PA. Dr. Deberardinis is a doctor who specializes in the health care of children. As a pedicatrician, Dr. Deberardinis diagnoses and treats infections, injuries, diseases and other disorders in children. Pediatricians typically work with infants, children, teenagers and young adults up to age 21. They practice medical care as well as preventative health care. Dr. Deberardinis can oversee and manage the physical, mental and emotional health of their patients.
Education and Training
Univ of Pa Sch of Med, Philadelphia Pa 2000
Perelman School of Medicine at the University of Pennsylvania 1996
Medical GeneticsAmerican Board of Medical GeneticsABMG
PediatricsAmerican Board of PediatricsABP
- Exon shuffling by L1 retrotransposition.
- Analysis of the promoter from an expanding mouse retrotransposon subfamily.
- Determination of L1 retrotransposition kinetics in cultured cells.
- A mouse model of human L1 retrotransposition.
- The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation.
- Autophagy in metazoans: cell survival in the land of plenty.
- Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth.
- The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis.
- Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.
- Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
- The biology of cancer: metabolic reprogramming fuels cell growth and
- Brick by brick: metabolism and tumor cell growth.
- Is cancer a disease of abnormal cellular metabolism? New angles on an old idea.
- Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.
- Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.
- EXPANDED NEWBORN SCREENING: A REVIEW FOR THE PEDIATRIC PATHOLOGIST.
- 2010 Keystone Symposium: Metabolism and Cancer Progression.
- Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death.
- Isocitrate dehydrogenase 1/2 mutational analyses and 2-hydroxyglutarate measurements in Wilms tumors.
- Targeting the metabolic flexibility of cancer cells: straighten up and die right.
- Glutamine: pleiotropic roles in tumor growth and stress resistance.
- Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.
- Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.
- Role of glutamine in cancer: therapeutic and imaging implications.
- Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
- Serine metabolism: some tumors take the road less traveled.
- Reductive carboxylation supports growth in tumour cells with defective mitochondria.
- Good neighbours in the tumour stroma reduce oxidative stress.
- Metabolism of [U-13 C]glucose in human brain tumors in vivo.
- Cellular metabolism and disease: what do metabolic outliers teach us?
- Genetically-defined metabolic reprogramming in cancer.
- The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.
- Cancer metabolism: When more is less.
- A mitochondrial power play in lymphoma.
- AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.
- Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.
- Cancer. Silencing a metabolic oncogene.
- The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.
- Role of PFKFB3-driven glycolysis in vessel sprouting.
- Hydrophilic interaction liquid chromatography coupled with MS/MS to detect and quantify dicarboxyethyl glutathione, a metabolic biomarker of the fumarate hydratase deficient cancer cell.
- Glutamine and cancer: cell biology, physiology, and clinical opportunities.
- Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
- Metabolic changes in cancer cells upon suppression of MYC.
- A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals.
- Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow.
- Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.
- Q&A: Targeting metabolism to diagnose and treat cancer.
- A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography.
- A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.
- Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.
- Analysis of hypoxia-induced metabolic reprogramming.
- Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.
- Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition.
- Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction.
- A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.
- Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.
- MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.
- Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.
- NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone.
- In vivo analysis of lung cancer metabolism: nothing like the real thing.
- Metabolic pathways promoting cancer cell survival and growth.
- Metabolism: Growth in the fat lane.
- Metabolic dysregulation in monogenic disorders and cancer - finding method in
- Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells.
- D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2.
- Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.
- Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia.
- A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles.
- Oxidative stress inhibits distant metastasis by human melanoma cells.
- NRF2 regulates serine biosynthesis in non-small cell lung cancer.
- Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis.
- TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions.
- Metabolic Heterogeneity in Human Lung Tumors.
- Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer.
- Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
- Liposuction: Extracellular Fat Removal Promotes Proliferation.
- From "N of 1" to N of more.
- Proliferating Cells Conserve Nitrogen to Support Growth.
- Fundamentals of cancer metabolism.
- Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.
- Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma.
- Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities.
- Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine.
- Glutathione Depletion, Pentose Phosphate Pathway Activation, and Hemolysis in Erythrocytes Protecting Cancer Cells from Vitamin C-induced Oxidative Stress.
- Erratum: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma.
- Blocking fatty acid synthesis reduces lung tumor growth in mice.
- Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein.
- Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.
- Understanding the Intersections between Metabolism and Cancer Biology.
- Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
- Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
- CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
- Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate
- Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI.
- Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.
- The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
- Engineering approaches to study cancer metabolism.
- Lactate Metabolism in Human Lung Tumors.
- The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.
- High frequency retrotransposition in cultured mammalian cells.
- Full-length L1 elements have arisen recently in the same 1-kb region of the gorilla and human genomes.
- Rapid amplification of a retrotransposon subfamily is evolving the mouse genome.
- 2007 CHOP Pediatric Scholars Program & Faculty Honor Roll - - American Soci
- 2011 Damon Runyon Cancer Research Foundation Clinical Investigator Award
- 2008 President's Research Council Distinguished Young Researcher Award
- Mitochondrial Disease, Metabolism
- Member American Academy of Pediatrics
- Member American Association for Cancer Research
- Member American Society of Human Genetics
- Member Society for Inherited Metabolic Disorders
- Member Society for Pediatrics Research
- Children'S Hosp-Philadelphia, Medical Genetics
- The Children's Hospital of Philadelphia 2005
- Children's Hospital Program
Dr. Ralph J Deberardinis MD PHD's Practice location
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- Cold Sores in Babies
As we all know, newborn babies do not develop strong immune systems immediately. Their bodies are still in the midst of the human development process and are adapting to the changes they face in the outside world. Thus, cold sores in newborn babies with weak immune systems can be extremely...
- Low-Grade Fever and Teething
Introduction Your baby, who used to be so peaceful, has all of a sudden become fussy, cranky, chews on every single thing, and is drooling. He wants to be held, keeps you half the night awake, and wants to be nursed the whole day. This is the world of teething that the baby has entered in. Other...
- The Value of Clinical Intuition: Kids also Experience Drug Side Effects
Clinical intuition is difficult to describe. Personally, it is the art of integrating nonverbal information that a patient presents in order to reach a diagnosis, reducing the need for diagnostic testing. This is especially important in children who often react differently to procedures, tests and...
- How Often Should a Newborn Poop?
First-time parents may wonder how often their newborn should poop and what a normal newborn poop would look like. A baby’s health can be best indicated by a baby’s bowel movement, but new parents may not know what to expect. For this reason, new parents become unsure and apprehensive during...
- What Is Cyanosis and Why Does It Occur?
IntroductionCyanosis is the medical term for a bluish discoloration of the skin, nails, toes, and mucous membranes. It is generally caused by low levels of oxygen in the blood. Normally, blood appears bright red when it is fully oxygenated. However, when blood does not have enough oxygen, it turns...
- Schoolboy with Autism Responds to Bullies in a Powerful Way
It is an unfortunate part of life that some children will end up bullying other people their age. Some children seem to have an uncanny ability to hone in on a difference and exploit it, turning it into a weakness and hurting the other kid.Children with autism are especially vulnerable. They are...
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