Dr. Louis J. Muglia MD
Endocronologist (Pediatric) | Pediatric Endocrinology
3333 Burnet Ave. Ml 7009 Cincinnati OH, 45229About
Louis J. Muglia, MD, is a leading endocrinologist currently serving patients as Co-Director of the Perinatal Institute, Director of the Center for Prevention of Preterm Birth, and Director and of the Division of Human Genetics at Cincinnati Children's Hospital Medical Center in Cincinnati, Ohio. Dr. Muglia also works as Professor at the University of Cincinnati School of Medicine Department of Pediatrics. Throughout his twenty-five years of practice, he has accrued extensive expertise in endocrine stress response. After earning his medical degree. Dr. Muglia has pioneered the in vivo analyses of regulation of the endocrine stress response and the molecular pathways leading to birth using novel genetically altered mutant mice. These studies have elucidated the importance of corticotropin-releasing hormone, glucocorticoids, and prostaglandins in neuroendocrine modulation, behavior, and perinatal adaptation. These studies have evolved over the last decade to specifically focus on the mechanisms controlling the timing for birth in humans using genetics and comparative genomics. The composition of the biological clock metering the duration of human gestation remains a central question in reproductive biology. The goal of the Muglia Laboratory is to understand the molecular timing machinery comprising this biological clock to prevent or better treat human preterm labor and delivery. Among Dr. Mugliaâ??s achievements are more than 180 publications and many awards, including a Burroughs Wellcome Fund Career Development Award in the biomedical sciences, the Society of Pediatric Research Young Investigator Award, and election to the American Society for Clinical Investigation and Association of American Physicians. In 2010, Dr. Muglia was elected to fellow in the American Association for the Advancement of Science. He is an active member of the Society for Pediatric Research, Society for Neuroscience, and the Lawson Wilkins Pediatric Endocrine Society. Dr. Muglia currently serves as chair of the Board of Scientific Counselors for the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health. In 2013, Dr. Muglia was elected to membership in the Institute of Medicine of the National Academies.
Education and Training
Univ of Chicago, Pritzker Sch of Med, Chicago Il 1988
Board Certification
PediatricsAmerican Board of PediatricsABP
Provider Details
Expert Publications
Data provided by the National Library of Medicine- The 5'-flanking region of the mouse adenylyl cyclase type VIII gene imparts tissue-specific expression in transgenic mice.
- Reciprocal changes in the expression of transcription factors GATA-4 and GATA-6 accompany adrenocortical tumorigenesis in mice and humans.
- Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP.
- Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2.
- Genetic analysis of fetal development and parturition control in the mouse.
- Gene knockout mice in the study of parturition.
- Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse.
- Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.
- Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation.
- Oxytocin modulates the onset of murine parturition by competing ovarian and uterine effects.
- Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice.
- Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration.
- COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production.
- Oxytocin mediates stress-induced analgesia in adult mice.
- Coordinate regulation of prostaglandin metabolism for induction of parturition in mice.
Awards
- Member 2013 National Academy of Medicine
Articles and Publications
- Over 200 publications
What do you attribute your success to?
- He believes the clinical research he does helps and is beneficial
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