Douglas B Sawyer MD
Cardiologist | Cardiovascular Disease3601 The Vanderbilt Clinic Nashville TN, 37232
Dr. Douglas Sawyer is a cardiologist practicing in Nashville, TN. Dr. Sawyer specializes in diagnosing, monitoring, and treating diseases or conditions of the heart and blood vessels and the cardiovascular system. These conditions include heart attacks, heart murmurs, coronary heart disease, and hypertension. Dr. Sawyer also practices preventative medicine, helping patients maintain a heart-healthy life.
Internal MedicineAmerican Board of Internal MedicineABIM- Cardiovascular Disease
Internal MedicineAmerican Board of Internal MedicineABIM
- Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane.
- Cytokine-mediated apoptosis in cardiac myocytes: the role of inducible nitric oxide synthase induction and peroxynitrite generation.
- NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK.
- Adrenergic overload and apoptosis in heart failure: implications for therapy.
- High-throughput assessment of calcium sensitivity in skinned cardiac myocytes.
- Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes.
- Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes.
- Myocardial hibernation: restorative or preterminal sleep?
- Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity.
- The sting of salt on an old, but open, wound--is Na(+) the cause of mitochondrial and myocardial injury during ischemia/reperfusion?
- Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle.
- Titin determines the Frank-Starling relation in early diastole.
- Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study.
- Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta.
- Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study.
- Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt.
- Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes.
- Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through
- Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling.
- Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes.
- Modulation of cardiac function: titin springs into action.
- The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance training.
- The cardiotoxicology of anthracycline chemotherapeutics: translating molecular mechanism into preventative medicine.
- Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium.
- Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes.
- Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective effect of tamoxifen (TAM).
- Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro.
- Heart failure research continues to reveal the flaws in nature's unintelligent design.
- Heat shock proteins in cancer: chaperones of tumorigenesis.
- Rapid electrical stimulation induces early activation of kinase signal
- Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes.
- Gramicidin single-channel properties show no solvent-history dependence.
- Cardiac amyloidosis: shifting our impressions to hopeful.
- Gramicidins A, B, and C form structurally equivalent ion channels.
- Molecular and cellular mechanisms of anthracycline cardiotoxicity.
- Predicting and preventing the cardiotoxicity of cancer therapy.
- Anthracycline cardiotoxicity: from bench to bedside.
- The role of Neuregulin-1beta/ErbB signaling in the heart.
- Palmitate alters neuregulin signaling and biology in cardiac myocytes.
- Vascular endothelial growth factor, its soluble receptor, and hepatocyte growth factor: clinical and genetic correlates and association with vascular function.
- Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes.
- Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure.
- Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms.
- Is there more for us to learn from oncology?: Examining the implications of anthracycline effects on the young heart.
- Clinical and genetic correlates of circulating angiopoietin-2 and soluble Tie-2 in the community.
- Emerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern?
- Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community.
- Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness.
- Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?
- Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage.
- Neuregulin-1β regulation of embryonic endothelial progenitor cell survival.
- Neuregulin-1β for the treatment of systolic heart failure.
- Oxidative stress in heart failure: what are we missing?
- Heart disease in cancer patients: a burgeoning field where optimizing patient care is requiring interdisciplinary collaborations.
- The vascular marker soluble fms-like tyrosine kinase 1 is associated with disease severity and adverse outcomes in chronic heart failure.
- Circulating neuregulin-1β levels vary according to the angiographic severity of coronary artery disease and ischemia.
- Early changes in clinical characteristics after emergency department therapy for acute heart failure syndromes: identifying patients who do not respond to standard therapy.
- ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.
- Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy.
- Elevated urinary neutrophil gelatinase-associated lipocalcin after acute heart failure treatment is associated with worsening renal function and adverse events.
- Cardiac side effects of anticancer treatments: new mechanistic insights.
- Galectin 3 complements BNP in risk stratification in acute heart failure.
- Neuregulin in cardiovascular development and disease.
- Risk stratification in acute heart failure: rationale and design of the STRATIFY and DECIDE studies.
- ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions.
- Circulating neuregulin during the transition from stage A to stage B/C heart failure in a breast cancer cohort.
- Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1β improves left ventricular function, gene and protein expression in rats after myocardial infarction.
- Soluble ST2 as a Diagnostic and Prognostic Marker for Acute Heart Failure Syndromes.
- Anthracyclines and heart failure.
- Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1β/ErbB in response to myocardial infarction resulting in worsening heart failure.
- Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure.
- Neuregulin as a heart failure therapy and mediator of reverse remodeling.
- Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors.
- Induction of conductance heterogeneity in gramicidin channels.
- Platelet-activating factor is a general membrane perturbant.
- Sympathetic nervous system alterations with HER2+ antagonism: an early marker of cardiac dysfunction with breast cancer treatment?
- Anti-remodeling and anti-fibrotic effects of the neuregulin-1β glial growth factor 2 in a large animal model of heart failure.
- Genome-wide association study for endothelial growth factors.
- Dibutyryl-cAMP increases basolateral sodium conductance of mosquito Malpighian tubules.
- Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways.
- Cardio-Oncology: An Update on Cardiotoxicity of Cancer-Related Treatment.
- Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores.
- Diagnostic Utility of Neuregulin for Acute Coronary Syndrome.
- Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix.
- Circulating vascular endothelial growth factor and the risk of cardiovascular events.
- Novel Biological Therapies Targeting Heart Failure: Myocardial Rejuvenation.
- Cardiac Dysfunction Due to Cancer Therapy: Finding New Directions.
- Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction.
- Biomimetic microstructure morphology in electrospun fiber mats is critical for maintaining healthy cardiomyocyte phenotype.
- ERBB signaling attenuates proinflammatory activation of nonclassical monocytes.
- Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts.
- Cardio-Oncology-A Rapidly Evolving and Expanding Field of Medicine.
- GRMD cardiac and skeletal muscle metabolism gene profiles are distinct.
- Species-specific effects of neuregulin-1β (cimaglermin alfa) on glucose handling in animal models and humans with heart failure.
- Chronic Neuregulin-1β Treatment Mitigates the Progression of Postmyocardial Infarction Heart Failure in the Setting of Type 1 Diabetes Mellitus by Suppressing Myocardial Apoptosis, Fibrosis, and Key Oxidant-Producing Enzymes.
- Mechanism of fluid secretion in isolated shark renal proximal tubules.
- Renal proximal tubule of flounder II. Transepithelial Mg secretion.
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Patient Experience with Dr. Sawyer
- Lisinopril: What Are the Side Effects and Dosages of Lisinopril?
The standard dose of this medication for adults with high blood pressure is 10 mg taken by mouth once a day.The doctor may increase the dose up to a maximum of 80 mg per day depending on the requirement. For heart failures, the starting dose for adults is 5 mg per day and the dosage can be increased...
- What Is a Bubble Study?
What is a bubble study?A bubble study is a type of echocardiogram, which is the ultrasound of the heart. An echocardiogram is done to visualize the heart and its surrounding areas. Better images of the heart can be produced when a “contrast” is used during the echocardiogram. In a bubble study,...
- What You Need to Know About Coronary Heart Disease (CHD)
What is CHD?Coronary heart disease (CHD) is the disease that develops when there is an insufficient oxygen supply to the heart muscle by the coronary arteries. The most common reason for this is atherosclerosis of the coronary arteries with cholesterol plaques formation and narrowing of the arterial...
- Hydrochlorothiazide and Diabetes
DiabetesInsulin is a hormone that is secreted by the pancreas. Diabetes can develop when the pancreas stops secreting insulin or when the body becomes resistant to insulin. The most common type of diabetes is type 2 diabetes.According to the American Diabetes Association, more than 25 million people...
- What are Atrial Fibrillation Blood Clots?
What are Atrial Fibrillation Blood Clots?Perhaps the terms Atrial Fibrillation Blood Clots are familiar with your ears or may be not, as the opposite applies to many and may be you are one of them. If you are in the latter group of people, then worry only if you have not read this article to the end...
- Arterial Disease is Constantly Undiagnosed in Women
Many women in United States is having peripheral artery disease (PAD), out of which, many are not diagnosed. The American Heart Association has called for a ‘Go Red for Women’ campaign to have increased participation to identify and diagnose this disease in women. The association also invites...
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