Dr. Justin R Connor MD
Orthopaedic Surgeon (Pediatric) | Pediatric Orthopaedic Surgery2041 Georgia Ave NW Washington DC, 20060
Dr. Justin Connor is a pediatric orthopaedic surgeon practicing in Washington, DC. Dr. Connor specializes in the diagnosis, treatment and rehabilitation of injuries, diseases and disorders of the bodys musculoskeletal system in children. As a pediatric orthopaedic surgeon, Dr. Connor tends to childrens bones, ligaments, muscles, joints, nerves and tendons. Pediatric orthopaedic surgeons can treat newborns to teenagers. Some conditions Dr. Connor treats include gait abnormalities like limping, limp and spine deformities, broken bones and bone and joint infections.
Education and Training
Washington Center / School of Medicine 2005
Washington University in St. Louis School of Medicine 2005
- Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat.
- Influence of calcium and iron on cell death and mitochondrial function in oxidatively stressed astrocytes.
- Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas.
- Reduction in the structural changes of experimental osteoarthritis by a nitric oxide inhibitor.
- Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains.
- Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues.
- Cellular distribution of iron in the brain of the Belgrade rat.
- Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors.
- Influence of nitric oxide on cellular and mitochondrial integrity in oxidatively stressed astrocytes.
- Screening of transcriptionally regulated genes following iron chelation in human astrocytoma cells.
- Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain.
- Bone structural and mechanical properties are affected by hypotransferrinemia but not by iron deficiency in mice.
- Identification of iron responsive genes by screening cDNA libraries from suppression subtractive hybridization with antisense probes from three iron conditions.
- CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues.
- Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization.
- Existing and emerging mechanisms for transport of iron and manganese to the brain.
- Differential expression of egr-1 in osteoarthritic compared to normal adult human articular cartilage.
- Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level.
- Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis.
- Iron deficiency alters H- and L-ferritin expression in rat brain.
- Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains.
- cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs.
- Interleukin-1beta increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool.
- Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures.
- FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis.
- Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta.
- Insight into the pathophysiology of restless legs syndrome.
- Hypoxic/ischemic insult alters ferritin expression and myelination in neonatal rat brains.
- Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption.
- Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain.
- Iron and neurodegenerative disorders.
- Abnormal iron accumulation in the brain of neonatal hypotransferrinemic mice.
- Iron and iron management proteins in neurobiology.
- Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.
- The intracellular location of iron regulatory proteins is altered as a function of iron status in cell cultures and rat brain.
- Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat.
- Clusterin expression in adult human normal and osteoarthritic articular cartilage.
- A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus.
- Increase in ferric and ferrous iron in the rat hippocampus with time after kainate-induced excitotoxic injury.
- Ferritin binding in the developing mouse brain follows a pattern similar to myelination and is unaffected by the jimpy mutation.
- Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury.
- Elevated cAMP is required for stimulation of eicosanoid synthesis by interleukin 1 and bradykinin in BALB/c 3T3 fibroblasts.
- Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system.
- NPC 15669 inhibits the reversed passive Arthus reaction in rats by blocking neutrophil recruitment.
- Iron regulation in the brain: histochemical, biochemical, and molecular considerations.
- Effect of manipulation of iron storage, transport, or availability on myelin composition and brain iron content in three different animal models.
- Distribution of divalent metal transporter-1 in the monkey basal ganglia.
- Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease.
- A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains.
- Transferrin receptor expression in myelin deficient (md) rats.
- Activation of the IL-1 gene in UV-irradiated mouse skin: association with inflammatory sequelae and pharmacologic intervention.
- Cellular iron status influences the functional relationship between microglia and oligodendrocytes.
- Expression of transferrin mRNA in the CNS of normal and jimpy mice.
- Acute and chronic effects of developmental iron deficiency on mRNA expression patterns in the brain.
- Ferritin: a novel mechanism for delivery of iron to the brain and other organs.
- Young coconut juice significantly reduces histopathological changes in the brain that are induced by hormonal imbalance: a possible implication to postmenopausal women.
- Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis.
- Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains.
- Interleukin-1 release by rat synovial cells is dependent on sequential treatment with gamma-interferon and lipopolysaccharide.
- Effect of HFE variants on sphingolipid expression by SH-SY5Y human neuroblastoma cells.
- Hypoxia-inducible factor pathway activation in restless legs syndrome patients.
- Gender-specific regulation of tyrosine hydroxylase in thymocyte differentiation antigen-1 knockout mice.
- Aluminum access to the brain: a role for transferrin and its receptor.
- Transferrin expression in myelinated and non-myelinated peripheral nerves.
- Altered cellular distribution of iron in the central nervous system of myelin deficient rats.
- A demonstration of glial filament distribution in astrocytes isolated from rat cerebral cortex.
- The development of the transferrin-transferrin receptor system in relation to astrocytes, MBP and galactocerebroside in normal and myelin-deficient rat optic nerves.
- Interleukin-1 induces interleukin-1 alpha and interleukin-1 beta gene expression in synovial fibroblasts and peripheral blood monocytes.
- Inhibition of IFN-gamma-induced Ia antigen expression on synovial fibroblasts by IL-1.
- Interleukin 1 stimulates prostaglandin synthesis and cyclic AMP accumulation in Swiss 3T3 fibroblasts: interactions between two second messenger systems.
- D-Phe7-substituted peptide bradykinin antagonists are not substrates for kininase II.
- Do oligodendrocytes mediate iron regulation in the human brain?
- The kallikrein-kininogen-kinin system in chronic inflammation.
- Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.
- Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts.
- Comparison of herpes simplex virus type 1 DNA replication and virus production in murine bone marrow-derived and resident peritoneal macrophages.
- Regulation of arachidonic acid metabolism in resident and BCG-activated alveolar macrophages: role of lyso(bis)phosphatidic acid.
- Regional variation in the levels of transferrin in the CNS of normal and myelin-deficient rats.
- Somatostatin-like neurons are expressed in fetal neocortical homografts in adult rat spinal cord.
- Development of transferrin-positive oligodendrocytes in the rat central nervous system.
- Receptor-mediated transcytosis of transferrin across the blood-brain barrier.
- The distribution of transferrin immunoreactivity in the rat central nervous system.
- Viruses and the versatile macrophage.
- Lyso(bis)phosphatidic acid: a novel source of arachidonic acid for oxidative metabolism by rabbit alveolar macrophages.
- A Golgi study of the superficial pyramidal cells in the somatosensory cortex of socially reared old adult rats.
- A quantitative Golgi study in the occipital cortex of the pyramidal dendritic topology of old adult rats from social or isolated environments.
- Environmental influences on serotonin and cyclic nucleotides in rat cerebral cortex.
- A comparison of dendritic spine number and type on pyramidal neurons of the visual cortex of old adult rats from social or isolated environments.
- Vasoactive intestinal polypeptide-immunoreactive neurons in rat visual cortex.
- Biochemical characteristics of dissociatively isolated aortic proteoglycans and their binding capacity to hyaluronic acid.
- High molecular weight proteoglycans biosynthesized in culture by pigeon aortas.
- A dichotomous response by two populations of layer V pyramidal neurons in the old adult rat visual cortex to differential housing conditions.
- Increased length of terminal dendritic segments in old adult rats' somatosensory cortex: an environmentally induced response.
- Plasticity of the aging cerebral cortex.
- A Golgi study of dendritic morphology in the occipital cortex of socially reared aged rats.
- Dendritic length in aged rats' occipital cortex: an environmentally induced response.
- Occipital cortical morphology of the rat: alterations with age and environment.
- Male modulation of female reproductive physiology in Norway rats: effects of mating during postpartum estrus.
- A study of atherosclerosis regression in Macaca mulatta: III. Chemical changes in arteries from animals with atherosclerosis induced for 19 months and regressed for 48 months at plasma cholesterol concentrations of 300 or 200 mg/dl.
- Aging and environmental influences on two types of dendritic spines in the rat occipital cortex.
- Postpartum estrus in Norway rats. II. Physiology.
- Postpartum estrus in Norway rats. I. Behavior.
- Transferrin in the central nervous system of the shiverer mouse myelin mutant.
- A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains.
- A histochemical study of iron-positive cells in the developing rat brain.
- Cellular distribution of iron, transferrin, and ferritin in the hypotransferrinemic (Hp) mouse brain.
- Iron acquisition and expression of iron regulatory proteins in the developing brain: manipulation by ethanol exposure, iron deprivation and cellular dysfunction.
- Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats.
- Iron regulation in the developing rat brain: effect of in utero ethanol exposure.
- Iron regulation in the brain at the cell and molecular level.
- Mutation of aspartate residues in the third extracellular loop of the rat B2 bradykinin receptor decreases affinity for bradykinin.
- Isoforms of ferritin have a specific cellular distribution in the brain.
- Iron, transferrin, and ferritin in the rat brain during development and aging.
- Histological analysis of selected brain regions of hypotransferrinemic mice.
- Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease.
- Iron in the brain.
- Human osteoclast and giant cell differentiation: the apparent switch from nonspecific esterase to tartrate resistant acid phosphatase activity coincides with the in situ expression of osteopontin mRNA.
- 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
- Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: an in vitro and ex vivo study of remodeling bone.
- Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.
- Demonstration and characterization of the iron regulatory protein in human brain.
- Relationship of iron to oligodendrocytes and myelination.
- Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice.
- Cellular management of iron in the brain.
- The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey.
- Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains.
- Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo.
- Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats.
- Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages.
- Accumulation of iron by primary rat hepatocytes in long-term culture: changes in nuclear shape mediated by non-transferrin-bound forms of iron.
- Evidence for non-transferrin-mediated uptake and release of iron and manganese in glial cell cultures from hypotransferrinemic mice.
- 2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).
- An in vitro model for analysis of oxidative death in primary mouse astrocytes.
- Abnormal localization of iron regulatory protein in Alzheimer's disease.
- Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development.
- Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase.
- Immunohistochemical analysis of transferrin receptor: regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain.
- 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.
- Cellular distribution of ferritin subunits in postnatal rat brain.
- Transferrin response in normal and iron-deficient mice heterozygotic for hypotransferrinemia; effects on iron and manganese accumulation.
- Characterization and distribution of ferritin binding sites in the adult mouse brain.
- Cerebral Palsy
- Birth Defects
- Down Syndrome
- Abnormal Gait
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Patient Experience with Dr. Connor
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