Dr. Steven D. Douglas has been investigating cellular immune mechanisms and monocyte-macrophages over many years. He and his group investigate the interaction between neuropeptides, monocyte-macrophag ...
Education and Training
Jawaharlal Institute of Post Graduate Medicine Research, Pondicherry University 1963
- Methadone enhances human immunodeficiency virus infection of human immune cells.
- Quantification of substance p mRNA in human immune cells by real-time reverse transcriptase PCR assay.
- Real-time RT-PCR for quantitation of hepatitis C virus RNA.
- HIV enhances substance P expression in human immune cells.
- A non-peptide substance P antagonist down-regulates SP mRNA expression in human mononuclear phagocytes.
- Peripheral blood lymphocyte subsets in adolescents: a longitudinal analysis from the REACH project.
- Efavirenz liquid formulation in human immunodeficiency virus-infected children.
- Mimic-based RT-PCR quantitation of substance P mRNA in human mononuclear phagocytes and lymphocytes.
- Nested RT-PCR. Sensitivity controls are essential to determine the biological significance of detected mRNA.
- Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor.
- Substance P up-regulates macrophage inflammatory protein-1beta expression in human T lymphocytes.
- Increased proliferation within T lymphocyte subsets of HIV-infected adolescents.
- Human neuronal cells (NT2-N) express functional substance P and neurokinin-1 receptor coupled to MIP-1 beta expression.
- Interleukin-1beta stimulates macrophage inflammatory protein-1alpha and -1beta expression in human neuronal cells (NT2-N).
- CCR5 expression and beta-chemokine production during placental neonatal monocyte differentiation.
- Morphine enhances HIV infection of neonatal macrophages.
- TH1 and TH2 cytokine mRNA and protein levels in human immunodeficiency virus (HIV)-seropositive and HIV-seronegative youths.
- Substance P and Human Immunodeficiency Virus Infection: Psychoneuroimmunology.
- The relationships between substance abuse, psychosocial variables, and natural
- CD4+ and CD8+ T cell receptor repertoire perturbations with normal levels of T cell receptor excision circles in HIV-infected, therapy-naive adolescents.
- The effects of avoidance on cytotoxic/suppressor T cells in women with cervical lesions.
- Morphine enhances hepatitis C virus (HCV) replicon expression.
- Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes.
- Quantification of CCR5 mRNA in human lymphocytes and macrophages by real-time reverse transcriptase PCR assay.
- A non-peptide substance P antagonist (CP-96,345) inhibits morphine-induced NF-kappa B promoter activation in human NT2-N neurons.
- Interleukin-1beta induces macrophage inflammatory protein-1beta expression in human hepatocytes.
- CD8+CD38+ T cells but not HIV type 1 RNA viral load predict CD4+ T cell loss in a predominantly minority female HIV+ adolescent population.
- Alpha-defensins inhibit HIV infection of macrophages through upregulation of CC-chemokines.
- Natural killer cells inhibit hepatitis C virus expression.
- Substance P and neurokinin-1 receptor modulation of HIV.
- Hepatitis C, depressive symptoms, viral load, and therapy: interactions and reactions.
- Immune activation and oxidative damage in HIV-positive and HIV-negative adolescents.
- Real-time reverse transcription-PCR quantitation of substance P receptor (NK-1R) mRNA.
- Morphine inhibits CD8+ T cell-mediated, noncytolytic, anti-HIV activity in latently infected immune cells.
- Plasma cytokines and oxidative damage in HIV-positive and HIV-negative adolescents and young adults: a protective role for IL-10?
- CD8+ T cell depletion amplifies hepatitis C virus replication in peripheral blood mononuclear cells.
- Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines.
- Morphine withdrawal enhances hepatitis C virus replicon expression.
- Down syndrome: immunologic and epidemiologic associations-enigmas remain.
- Immune reconstitution and predictors of virologic failure in adolescents infected through risk behaviors and initiating HAART: week 60 results from the PACTG 381 cohort.
- Vitamins C and E in adolescents and young adults with HIV infection.
- Vitamin D status in adolescents and young adults with HIV infection.
- Measurement of plasma-derived substance P: biological, methodological, and statistical considerations.
- Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells.
- An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.
- Glutathione, glutathione peroxidase, and selenium status in HIV-positive and HIV-negative adolescents and young adults.
- Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus/acquired immunodeficiency syndrome.
- Detection of full-length and truncated neurokinin-1 receptor mRNA expression in human brain regions.
- NIMH Preclinical/Clinical Therapeutics Research meeting--preclinical drug discovery session.
- Neurokinin-1 receptor antagonist (aprepitant) inhibits drug-resistant HIV-1 infection of macrophages in vitro.
- Elevated plasma substance P in sickle cell disease and vaso-occlusive crisis.
- Perceived stress is associated with impaired T-cell response to HPV16 in women with cervical dysplasia.
- Analyses of HIV-1 drug-resistance profiles among infected adolescents experiencing delayed antiretroviral treatment switch after initial nonsuppressive highly active antiretroviral therapy.
- Neurokinin-1 receptor mRNA expression differences in brains of HIV-infected individuals.
- Neurokinin-1 receptor antagonist (aprepitant) suppresses HIV-1 infection of microglia/macrophages.
- Innate immune markers in mothers and fathers of children newly diagnosed with cancer.
- Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor.
- Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R).
- Neurokinin-1 receptor expression and function in human macrophages and brain: perspective on the role in HIV neuropathogenesis.
- Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinase-dependent mechanism.
- Novel method for determination of substance P levels in unextracted human plasma by using acidification.
- Neurokinin 1 receptor isoforms and the control of innate immunity.
- Enhanced psychosocial well-being following participation in a mindfulness-based stress reduction program is associated with increased natural killer cell activity.
- Neurokinin-1 receptor (NK1-R) expression in the brains of SIV-infected rhesus macaques: implications for substance P in NK1-R immune cell trafficking into the CNS.
- Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals.
- Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.
- Association between alcohol use and HIV viral load.
- A randomized, placebo controlled, double masked phase IB study evaluating the safety and antiviral activity of aprepitant, a neurokinin-1 receptor antagonist in HIV-1 infected adults.
- Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner.
- Substance P-neurokinin-1 receptor interaction upregulates monocyte tissue factor.
- Programmed death 1 receptor changes ex vivo in HIV-infected adults following initiation of highly active antiretroviral therapy.
- Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells.
- Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor.
- Expression of substance P, neurokinin-1 receptor and immune markers in the brains of individuals with HIV-associated neuropathology.
- Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.
- PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: are we asking the right questions?
- HIV infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance P.
- Modeling and simulation approach to support dosing and study design requirements for treating HIV-related neuropsychiatric disease with the NK1-R antagonist aprepitant.
- Immune markers predictive of neuropsychiatric symptoms in HIV-infected youth.
- Adjuvant therapies for HIV-associated neurocognitive disorders.
- Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults.
- Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV.
- Substance P and sickle cell disease-a marker for pain and novel therapeutic approaches.
- Decreased PD-1 Expression on CD8 Lymphocyte Subsets and Increase in CD8 Tscm Cells in Children with HIV Receiving Raltegravir.
- Substance P-mediated chemokine production promotes monocyte migration.
- Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults.
- The Legacy of CVI.
- Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor.
- 2012Philadelphia Super Doctors
- Moffitt Hosp Univ Of Ca, Other Specialty; Mt Sinai Med Ctr, Internal Medicine; Mt Sinai Med Ctr, Flexible Or Transitional Year
- Mount Sinai School of Medicine Affiliated Hospitals
- CEME/Mount Sinai Medical Center Program
- Immunology - University of California, San Francisco, San Francisco, CA
Dr. Steven D Douglas M.D.'s Practice location
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