Dr. Christopher Alan Slapak MD
Hematologist-Oncologist | Hematology & Oncology
The Wishard Hospital Hematology Clinic 1050 Wishard Blvd Indianapolis IN, 46202About
Dr. Christopher Slapak is a hematologist oncologist practicing in Indianapolis, IN. Dr. Slapak specializes in the diagnosis, treatment and prevention of blood diseases such as anemia, hemophilia, sickle-cell disease, leukemia and lymphoma. Hematologist Oncologists are also trained in the study of cancer and its attack on other organs.
Education and Training
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med 1984
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Medical Oncology
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Modulation by LY335979 of P-glycoprotein function in multidrug-resistant cell
- Reversal of multidrug resistance with LY335979: functional analysis of P-glycoprotein-mediated transport activity and its modulation in vivo.
- A very early induction of major vault protein accompanied by increased drug resistance in U-937 cells.
- A phase I trial of a potent P-glycoprotein inhibitor, Zosuquidar.3HCl trihydrochloride (LY335979), administered orally in combination with doxorubicin in patients with advanced malignancies.
- Identification and characterization of the canine multidrug resistance-associated protein.
- Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts.
- Treatment of acute myeloid leukemia in the elderly with low-dose cytarabine, hydroxyurea, and calcitriol.
- Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.
- A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients with advanced malignancy.
- An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines.
- Phase I study of docetaxel in combination with the P-glycoprotein inhibitor, zosuquidar, in resistant malignancies.
- Interferon protects normal human granulocyte/macrophage colony-forming cells from Ara-C cytotoxicity.
- Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.
- Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.
- Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors.
Dr. Christopher Alan Slapak MD's Practice location
Christopher Slapak
The Wishard Hospital Hematology Clinic 1050 Wishard Blvd -Indianapolis, IN 46202Get Direction
The Wishard Hospital Hematology Clinic
1050 Wishard Blvd -Indianapolis, IN 46202Get Direction
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