Dr. Leonard Dragone practices Pediatric Rheumatology in Denver, CO. Pediatric rheumatologists treat child patients who suffer from pain in the musculoskeletal system, have symptoms of arthritis, or an autoimmune disorder. Dr. Dragone evaluates and treats a variety of joint, muscle, and bone disorders; including autoimmune disorders, such as lupus, juvenile rheumatoid arthritis, scleroderma, Kawasaki disease, post-infectious arthritis, chronic vasculitis, and inflammatory disorders of the muscle, eye, or other organs. Dr. Dragone also is trained in the evaluation of prolonged fever, unexplained complaints of chronic musculoskeletal pain, weakness, poor appetite, fatigue, and/or loss of function or skills.
Education and Training
Univ of Rochester Sch of Med & Dentistry, Rochester Ny 1996
PediatricsAmerican Board of PediatricsABP- Pediatric Rheumatology
- Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.
- Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.
- SRC-like adaptor protein regulates B cell development and function.
- Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.
- Novel method for quantitative ANA measurement using near-infrared imaging.
- SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking.
- Acute hepatitis in three patients with systemic juvenile idiopathic arthritis taking interleukin-1 receptor antagonist.
- The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.
- SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.
- SLAP deficiency increases TCR avidity leading to altered repertoire and negative
- Pregnancy amelioration of arthritis in SKG mice corresponds with alterations in serum amyloid A3 levels.
- The launch of the American Journal of Clinical and Experimental Immunology.
- The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation.
- SLAP deficiency decreases dsDNA autoantibody production.
- SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and
- Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications.
- Univ Ca Sf Sch Of Med, Pediatric Rheumatology; Univ Ca Sf Sch Of Med, Pediatrics
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