Dr. Lucy D. Mastrandrea, MD, PhD

Expert Publications

• E2/E3-mediated assembly of lysine 29-linked polyubiquitin chains.
• Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines.
• Clinical and biochemical similarities between reflux/obstructive uropathy and salt-wasting congenital adrenal hyperplasia.
• Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells.
• Clinical evaluation of inhaled insulin.
• Information-theoretical entropy as a measure of sequence variability.
• Young women with type 1 diabetes have lower bone mineral density that persists over time.
• Inhaled insulin: overview of a novel route of insulin administration.
• Lingual thyroid as a cause of primary hypothyroidism: congenital hypothyroidism in the neonatal period and beyond.
• ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets.
• A breath of life for inhaled insulin: severe subcutaneous insulin resistance as an indication?
• Does the dopamine transporter protein allele predict growth hormone testing results or response to growth hormone therapy?
• Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat
• Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome.
• Methylphenidate decreases fat and carbohydrate intake in obese teenagers.

Clinical Trials

• DFMO in Children With Type 1 Diabetes

Media Releases

Get to know Pediatric Endocrinologist Dr. Lucy D. Mastrandrea, who serves patients in Buffalo, New York.

Treating children and adolescents, Dr. Mastrandrea is a fellowship-trained pediatric endocrinologist in practice with UBMD Pediatrics Outpatient Center in Buffalo, New York. Her specialities include endocrinology, pathophysiology, pediatric diabetes, pediatric endocrinology, and pediatrics.

Teaching the next generation of doctors and researching to advance care in WNY and beyond, she serves as an Associate Professor  within the Department of Pediatrics at Jacobs School of Medicine & Biomedical Sciences at the University at Buffalo.

Among her other appointments include Division Chief, Endocrinology/Diabetes, UBMD Pediatrics (2017-present); Medical Director, Diabetes Center, Oishei Children‘s Hospital (2017-present); Associate Fellowship Program Director, Endocrinology/Diabetes, University at Buffalo (2011-present); Adjunct Research Assistant Professor, Pharmacology and Toxicology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2008-present); and Attending Physician, Endocrinology/Diabetes, Oishei Children’s Hospital (2004-present).

Following the completion of her medical degree at the University at Buffalo School of Medicine and Biomedical Sciences, Dr. Mastrandrea went on to further her education. She performed her internship in pediatrics, residency in pediatrics, and fellowship in pediatric endocrinology at the University at Buffalo in 2000, 2001, and 2005, respectively. 

In 2004 and 2005, she attained board certification in pediatrics and pediatric endocrinology through the American Board of Pediatrics (ABP). The mission of the ABP is to advance child health by certifying pediatricians who meet standards of excellence and are committed to continuous learning and improvement.

A Fellow of the American Academy of Pediatrics, Dr. Mastrandrea is a member of the Pediatric Endocrine Society, the Endocrine Society, the American Diabetes Association, the American Academy of Pediatrics: Young Physicians Society, the Society for Pediatric Research, and the Lawson Wilkins Society of Pediatric Endocrinology/Pediatric Endocrine Society.

Her areas of research expertise include growth hormone deficiency, late endocrine effects of childhood cancer, Type 1 diabetes, Type 2 diabetes, and weight management and obesity.

Pediatric endocrinology is a medical subspecialty dealing with disorders of the endocrine glands, such as variations of physical growth and sexual development in childhood, diabetes, and many more. Pediatric endocrinologists, depending upon the age range of the patients they treat, care for patients from infancy to late adolescence and young adulthood. They treat type 1 and type 2 diabetes, growth disorders, pubertal abnormalities, obesity, differences of sex development, bone and mineral disturbances, hypoglycemia, and other disorders relating to the adrenal, parathyroid, thyroid, and pituitary glands.

Among Dr. Mastrandrea’s most notable achievements include: Castle Connolly Medical Ltd: Exceptional Women in Medicine (2019); Pediatric Endocrine Society: Leadership Advantage “Award of Accomplishment and Exemplary Completion” (2019); Gold Humanism Honor Society: Richard Sarkin/Emeritus Faculty Chapter Faculty Inductee (2019); Society for Pediatric Research: Awarded Membership (2012); American Diabetes Association: Mission Recognition “Exemplary Service Award” (2012); 85th Annual Endocrine Society Conference: Genentech Travel Grant (2003); Alpha Omega Alpha Honor Medical Society (1998); Edward A. Carr Pharmacology Award (1992); Phi Beta Kappa Honor Society (1990); Sigma Xi Honor Society (1989); PEW Fellowship Recipient (1989); Elks’ National Scholarship (1986); Bausch and Lomb: Science Award (1986); Castle Connolly Medical Ltd: America‘s Top Doctors (2016-2020); Endocrine Fellows Foundation Award (2002-2003); Manhattan College: Presidential Scholarship (1986-1990); Buffalo Spree Magazine: Top Doctors in Western New York (2016-2021); and Castle Connolly: Exceptional Women in Medicine (2019-2020).

Recommended Articles

• Hypothyroidism: Why Am I Always Exhausted?

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• What is Apert Syndrome?

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• What Is Pituitary Dwarfism?

  IntroductionPituitary dwarfism, also called growth hormone deficiency, is a medical condition wherein the pituitary gland does not produce sufficient amounts of growth hormone. This deficiency often results in children’s slow growth or short stature.An adult with pituitary dwarfism has an average...