Dr. Michael S Hershfield M.D.
Rheumatologist | Rheumatology
4101 N Roxboro St Durham NC, 27704About
Dr. Michael Hershfield is a rheumatologist practicing in Durham, NC. Dr. Hershfield specializes in the treatment of musculoskeletal diseases and systematic autoimmune conditions that can affect the bones, muscles or bones. Eventually, if not treated, these illnesses can also impact the skin, eyes, nervous system and internal organs. Dr. Hershfield treats diseases similar to orthopedists but does not perform surgery. Often times, research is conducted to find potential alternatives for the patients illness.
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Regulation of de novo purine biosynthesis in human lymphoblasts. Coordinate control of proximal (rate-determining) steps and the inosinic acid branch point.
- Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online.
- The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities.
- Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures.
- The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency.
- Molecular basis for paradoxical carriers of adenosine deaminase (ADA) deficiency that show extremely low levels of ADA activity in peripheral blood cells without immunodeficiency.
- Inhibition of fetal thymic caspases abrogates the consequences of adenosine deaminase deficiency.
- Adenosine deaminase deficiency with mosaicism for a "second-site suppressor" of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy.
- Flow cytometry analysis of adenosine deaminase (ADA) expression: a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy.
- Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV.
- E. coli expression system for identifying folding mutations of human adenosine deaminase.
- Antibody responses to bacteriophage phi X174 in patients with adenosine deaminase deficiency.
Dr. Michael S Hershfield M.D.'s Practice location
Practice At 4101 N Roxboro St
4101 N Roxboro St -Durham, NC 27704Get Direction
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Nearby Providers
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Dr. David S Pisetsky M.D.4101 N Roxboro St Durham NC 27704![]()
Dr. Kate Lawrence Mitchell MD120 WILLIAM PENN PLZ DURHAM NC 27704![]()
Dr. Laurie Dee Snyder MD4101 N Roxboro St Durham NC 27704![]()
Dr. Tony Ning MD120 William Penn Plz Durham NC 27704![]()
Dr. Irene Z Whitt M.D.120 WILLIAM PENN PLZ DURHAM NC 27704![]()
Dr. Anne K. Toohey M.D.120 WILLIAM PENN PLZ DURHAM NC 27704
Nearest Hospitals
DUKE UNIVERSITY HOSPITALl
PO BOX 3814 DUMC ERWIN RD DURHAM NC 27710DUKE REGIONAL HOSPITALl
3643 N ROXBORO ROAD DURHAM NC 27704