Dr. Knechtle, a nationally-recognized surgeon and a leader in the field of liver and kidney transplantation, focuses on finding safer and more effective ways to prevent rejection of organ transplants. ...
SurgeryAmerican Board of SurgeryABS
- CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T
- Involvement of protein tyrosine phosphorylation in immunotoxin effects on T lymphocytes.
- Iliac artery pseudoaneurysm following renal transplantation presenting as lumbosacral plexopathy.
- Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand.
- Ureteroneocystostomy for renal transplantation.
- Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.
- CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.
- Disseminated aspergillosis involving the brain: distribution and imaging characteristics.
- T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
- Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
- Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
- Knowledge about transplantation tolerance gained in primates.
- Increased glomerular deposits of von Willebrand factor in chronic, but not acute, rejection of primate renal allografts.
- What's new in transplantation.
- Treatment with immunotoxin.
- Immunotoxin FN18-CRM9 induces stronger T cell signaling than unconjugated monoclonal antibody FN18.
- Graft survival in a rhesus renal transplant model after immunotoxin-mediated T-cell depletion is enhanced by mycophenolate and steroids.
- Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients.
- Steps toward transplantation tolerance in the clinic.
- Tolerance and near-tolerance strategies in monkeys and their application to human renal transplantation.
- Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model.
- Involvement of linker for activation of T cells in the costimulatory signaling pathways.
- Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling.
- Sirolimus monotherapy following Campath-1H induction.
- Novel immunosuppressive agents in tolerance induction.
- Chronic allograft nephropathy uniformly affects recipients of cadaveric, nonidentical living-related, and living-unrelated grafts.
- Immunotoxin-treated rhesus monkeys: a model for renal allograft chronic rejection.
- Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells.
- Clinical trials: where are we now?
- Portal hypertension: from Eck's fistula to TIPS.
- Challenging choices: liver transplantation for hepatocellular carcinoma.
- Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction.
- Hyperlipidemia and transplantation: etiologic factors and therapy.
- Present experience with Campath-1H in organ transplantation and its potential use in pediatric recipients.
- Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model.
- Metastable tolerance in nonhuman primates and humans.
- Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
- Immune status assay (ISA): a noninvasive procedure for studying allograft rejection.
- Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction.
- Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine.
- Gene transfer and expression in rat cardiac transplants.
- Incidental living donor nephrectomy: a unique expansion of the donor pool.
- Selenium-binding protein-1 in smooth muscle cells is downregulated in a rhesus monkey model of chronic allograft nephropathy.
- Development of tolerogenic strategies in the clinic.
- T-lymphocyte alloresponses of Campath-1H-treated kidney transplant patients.
- The Art and Science of Immunosuppression: the Fifth Annual American Society of Transplant Surgeon's State-of-the-Art Winter Symposium.
- Determination of the functional status of alloreactive T cells by interferon-gamma kinetics.
- A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.
- The evolving role of alemtuzumab (Campath-1H) for immunosuppressive therapy in organ transplantation.
- How does alemtuzumab affect long-term graft and patient outcomes after deceased-donor kidney transplantation?
- Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantation.
- FK 506 rescue therapy for resistant rejection episodes in liver transplant recipients.
- CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.
- The effect of donor age, recipient age, and HLA match on immunologic graft survival in cadaver renal transplant recipients.
- Annual literature review for clinical transplants 2005.
- Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance.
- Indications and techniques for renal, pancreas, and liver transplantation.
- Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients.
- Macrophages driven to a novel state of activation have anti-inflammatory properties in mice.
- CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.
- Nonhuman primate infections after organ transplantation.
- Donor-specific HLA-antibody-mediated humoral rejection in a liver transplant recipient fully reversed with plasmapheresis and immunoglobulin.
- Alemtuzumab induction and triple maintenance immunotherapy in kidney transplantation from donors after cardiac death.
- Unaltered graft survival and intragraft lymphocytes infiltration in the cardiac allograft of Cxcr3-/- mouse recipients.
- Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: clinical outcomes and effect on T-regulatory cells.
- Risk factors and outcomes in post-liver transplantation bile duct stones and casts: A case-control study.
- Unique aspects of rejection and tolerance in liver transplantation.
- Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine.
- Urine osteoprotegerin and monocyte chemoattractant protein-1 in lupus nephritis.
- HLA-C and liver transplant outcomes: interpreting the facts.
- Overcoming Chronic Rejection-Can it B?
- Interleukin-15 receptor blockade in non-human primate kidney transplantation.
- Prevention trumps treatment of antibody-mediated transplant rejection.
- Cytokine kinetics profiling in pediatric renal transplant recipients.
- Biliary tract complications after orthotopic liver transplantation.
- Living-unrelated renal transplantation at the University of Wisconsin.
- Immunoregulation and tolerance.
- Use of OKT3 in kidney, pancreas, and liver transplantation.
- Seek and you will find: antibody and the liver.
- Donor-directed MHC class I antibody is preferentially cleared from sensitized recipients of combined liver/kidney transplants.
- Guidance for liver transplant immunosuppression.
- Miles to go….
- Liver transplantation for the treatment of hepatocellular carcinoma.
- Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.
- The role of B cells in solid organ transplantation.
- Biologics in organ transplantation.
- Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.
- Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.
- Tolerogenic therapies in transplantation.
- Anomalous biliary ducts associated with duodenal atresia.
- Domino liver transplantation in maple syrup urine disease: a case report and review of the literature.
- Reply to Vanhove et al.
- Post-transplant lymphoproliferative disorder associated with immunosuppressive therapy for renal transplantation in rhesus macaques (Macaca mulatta).
- Induction immunosuppression in liver transplantation: a review.
- Experience with reduced-size liver transplantation in infants and children.
- Urine proteomics in kidney transplantation.
- Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.
- Belatacept: is there BENEFIT for liver transplantation too?
- Systems biological analyses reveal the hepatitis C virus (HCV)-specific
- The clinical relevance of alloantibody in liver transplantation.
- Open-label prospective study of the safety and efficacy of glass-based yttrium 90 radioembolization for infiltrative hepatocellular carcinoma with portal vein thrombosis.
- Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous
- Perforation of the gastrointestinal tract following renal transplantation.
- One Size Does Not Fit All--Regional Variation in the Impact of the Share 35 Liver Allocation Policy.
- Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology.
- Regulating T Cell Behavior.
- Reply to: "Percutaneous Management of Benign Biliary Strictures: Is It Time to Focus on Reducing Procedure Invasiveness?".
- Expanding the Donor Pool With Normothermic Ex Vivo Liver Perfusion: The Future Is Now.
- Bridging Locoregional Therapy Prolongs Survival in Patients Listed for Liver Transplant with Hepatocellular Carcinoma.
- Crosstalk Between T and B Cells in the Germinal Center After Transplantation.
- Mediation of hyperacute rejection of rat hepatic allografts by RT-1 antigens.
- Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.
- Alpha 1-adrenergic effects and liver regeneration.
- Infiltrative Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Treated With a Single High-Dose Y90 Radioembolization and Subsequent Liver Transplantation Without a Recurrence.
- Hyperacute rejection of liver transplants in rats.
- Hepatic transplantation into sensitized recipients. Demonstration of hyperacute rejection.
- Infiltrating cell phenotypes and patterns associated with hepatic allograft rejection or acceptance.
- Phenotype and patterns of inflammatory cell infiltration associated with rejection or acceptance of rat liver allografts.
- Humoral rejection of rat hepatic transplants by passive transfer of serum.
- Peptic ulcer disease following renal transplantation.
- Monitoring of kidney and simultaneous pancreas-kidney transplantation rejection by release of donor-specific, soluble HLA class I.
- Use of donor serum to prevent passive transfer of hyperacute rejection.
- Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex.
- Two hundred consecutive simultaneous pancreas-kidney transplants with bladder drainage.
- Urological complications in 210 consecutive simultaneous pancreas-kidney transplants with bladder drainage.
- Human interleukin-2 and lymphoproliferative (T-helper cell) responses to soluble HLA class I antigens in vitro: I. Specificity for polymorphic domains.
- Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle.
- Immunosuppressive effects of an HLA class I-derived peptide in a rat cardiac allograft model.
- Adenovirus-mediated gene transfer into rat cardiac allografts. Comparison of direct injection and perfusion.
- Gene therapy and transplantation--a brief review.
- Gene therapy in transplantation.
- Identification of new mamu-DRB alleles using DGGE and direct sequencing.
- Mechanisms of tolerance induced by an immunotoxin against CD3 epsilon in a rhesus kidney allograft model.
- Split tolerance induced by immunotoxin in a rhesus kidney allograft model.
- Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms.
- CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.
- Procurement, preservation, and transport of cadaver kidneys.
- Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules.
- Rejection of the liver transplant.
- Primate renal transplants using immunotoxin.
- Reversal of acute allograft rejection using immunotoxin.
- Strategies for tolerance induction in nonhuman primates.
- Modulation of alloimmunity to major histocompatibility complex class I by cotransfer of cytokine genes in vivo.
- 2012Atlanta Super Doctors
- Liver Transplant, Liver Surgery
- MemberAmerican Association for the Study of Liver Diseases
- Member American Association of Immunologists
- Member American College of Surgeons
- Member American Society of Transplant Surgeons
- Member American Society of Transplantation
- Member American Surgical Association
- Member Association for Academic Surgery
- Member Emory Healthcare Network Physician
- Univ Of Wi Hosp & Cli, General Surgery; Duke Univ Med Ctr, General Surgery
- Duke University Hospital
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