Dr. Paul B Mccray MD?
Dr. Paul B Mccray MD
Pulmonologist (Pediatric) | Pediatric Pulmonology
200 Hawkins Dr Iowa City IA, 52242About
Dr. Paul Mccray practices Pediatric Pulmonology in Iowa City, IA. Dr. Mccray treats children who have breathing problems, or a problem with his or her lungs. Pediatric pulmonologists often treat children with chronic cough, difficulty breathing, recurring pneumonia, asthma, cystic fibrosis, apnea, chronic lung disease in premature infants, noisy breathing, and conditions that require special equipment to monitor and/or help with breathing at home.
Education and Training
Baylor College of Medicine, Houston, Texas 1981
Board Certification
PediatricsAmerican Board of PediatricsABP- Pediatric Pulmonology
Provider Details
Expert Publications
- Development of the innervation and airway smooth muscle in human fetal lung.
- Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands.
- Efficient killing of inhaled bacteria in DeltaF508 mice: role of airway surface liquid composition.
- Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins.
- Human beta-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium.
- KGF and FGF-10 stimulate liquid secretion in human fetal lung.
- Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect.
- Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo.
- Keratinocyte growth factor induced epithelial proliferation facilitates retroviral-mediated gene transfer to distal lung epithelia in vivo.
- Fetal airway smooth-muscle contractility and lung development. A player in the band or just someone in the audience?
- A novel murine beta -defensin expressed in tongue, esophagus, and trachea.
- Human coronavirus 229E infects polarized airway epithelia from the apical surface.
- Synergistic and additive killing by antimicrobial factors found in human airway surface liquid.
- The ovine cathelicidin SMAP29 kills ovine respiratory pathogens in vitro and in an ovine model of pulmonary infection.
- Abundant human beta-defensin-1 expression in milk and mammary gland epithelium.
- Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma.
- Discovery of new human beta-defensins using a genomics-based approach.
- Development of retroviral vectors for gene transfer to airway epithelia.
- Infection of human airway epithelia with H1N1, H2N2, and H3N2 influenza A virus strains.
- The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment.
- Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.
- In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors.
- Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa.
- Cathelicidin peptides inhibit multiply antibiotic-resistant pathogens from patients with cystic fibrosis.
- Susceptibilities of oral bacteria and yeast to mammalian cathelicidins.
- Congeners of SMAP29 kill ovine pathogens and induce ultrastructural damage in bacterial cells.
- The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus.
- Cystic fibrosis. Difficulties of gene therapy.
- [beta]-defensins in lung host defense.
- Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia.
- Discovery of five conserved beta -defensin gene clusters using a computational search strategy.
- Gene transfer to airway epithelia using feline immunodeficiency virus-based lentivirus vectors.
- Apical barriers to airway epithelial cell gene transfer with amphotropic retroviral vectors.
- Endogenous and exogenous glucocorticoid regulation of ENaC mRNA expression in developing kidney and lung.
- Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation.
- In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins.
- Genomics-based approaches to gene discovery in innate immunity.
- Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease.
- Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha.
- CCL20 is an inducible product of human airway epithelia with innate immune properties.
- Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins.
- Developmental expression and distribution of sheep beta-defensin-2.
- Localization of cystic fibrosis transmembrane conductance regulator mRNA in human fetal lung tissue by in situ hybridization.
- Antimicrobial peptides in animals and their role in host defences.
- Novispirin G10-induced lung toxicity in a Klebsiella pneumoniae infection model.
- Large-scale gene discovery in human airway epithelia reveals novel transcripts.
- Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2.
- Expression and activity of beta-defensins and LL-37 in the developing human lung.
- Viscoelastic gel formulations enhance airway epithelial gene transfer with viral vectors.
- Inclusion of Jaagsiekte sheep retrovirus proviral elements markedly increases lentivirus vector pseudotyping efficiency.
- Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein.
- Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer.
- Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors--design, biosafety, and production.
- Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer.
- ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia.
- Pathogenesis of early lung disease in cystic fibrosis: a window of opportunity to eradicate bacteria.
- Integration site choice of a feline immunodeficiency virus vector.
- Monocytic/macrophagic pneumonitis after intrabronchial deposition of vascular endothelial growth factor in neonatal lambs.
- Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization.
- Developing fetal alveolar epithelial cells secrete fluid in primary culture.
- Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events.
- Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector.
- In vivo imaging of gene transfer to the respiratory tract.
- MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state.
- PLUNC is a secreted product of neutrophil granules.
- Basolateral entry and release of New and Old World arenaviruses from human airway epithelia.
- Innate immune functions of the airway epithelium.
- Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed.
- Differential gene expression in human conducting airway surface epithelia and submucosal glands.
- Lentivirus vector can be readministered to nasal epithelia without blocking immune responses.
- Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.
- The piglet as a model for B cell and immune system development.
- Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia.
- Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors.
- Progress and prospects: prospects of repeated pulmonary administration of viral vectors.
- Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease.
- Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia.
- Integrase-defective lentiviral vectors: progress and applications.
- The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways.
- Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae.
- PLUNC is a novel airway surfactant protein with anti-biofilm activity.
- Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth.
- Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children.
- The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia.
- A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A.
- Genetic therapies for cystic fibrosis lung disease.
- Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide.
- Altering α-dystroglycan receptor affinity of LCMV pseudotyped lentivirus yields unique cell and tissue tropism.
- Current prospects for RNA interference-based therapies.
- Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein.
- T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus.
- Microarray mRNA expression profiling to study cystic fibrosis.
- PLUNC: a multifunctional surfactant of the airways.
- Adherens junction protein nectin-4 is the epithelial receptor for measles virus.
- An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis.
- Advances in cell and gene-based therapies for cystic fibrosis lung disease.
- Transcriptional targeting in the airway using novel gene regulatory elements.
- CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia.
- Pancreatic damage in fetal and newborn cystic fibrosis pigs involves the activation of inflammatory and remodeling pathways.
- Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.
- A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator.
- Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections.
- Lentiviral vector gene transfer to porcine airways.
- Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia.
- A Hyperactive Transposase Promotes Persistent Gene Transfer of a piggyBac DNA Transposon.
- Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors.
- SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection.
- Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro.
- Post-transcriptional regulation of cystic fibrosis transmembrane conductance regulator expression and function by microRNAs.
- Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
- piggyBac transposase tools for genome engineering.
- Person-to-person spread of the MERS coronavirus--an evolving picture.
- Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity.
- A novel gene delivery method transduces porcine pancreatic duct epithelial cells.
- Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection.
- Effects of airway surface liquid pH on host defense in cystic fibrosis.
- Rapid generation of a mouse model for Middle East respiratory syndrome.
- A genomic signature approach to rescue ΔF508-cystic fibrosis transmembrane conductance regulator biosynthesis and function.
- miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production.
- Platelet Activating Factor Receptor Activation Improves siRNA Uptake and RNAi Responses in Well-differentiated Airway Epithelia.
- Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy.
- The innate immune function of airway epithelial cells in inflammatory lung disease.
- Increased susceptibility to otitis media in a Splunc1-deficient mouse model.
- piggyBac-mediated phenotypic correction of factor VIII deficiency.
- Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4.
- Highly differentiated human airway epithelial cells: a model to study host cell-parasite interactions in pertussis.
- Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome.
- Human, Pig, and Mouse Interferon-Induced Transmembrane Proteins Partially Restrict Pseudotyped Lentiviral Vectors.
- NETs and CF Lung Disease: Current Status and Future Prospects.
- Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus.
- Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive Bacteria.
- Lentiviral-mediated phenotypic correction of cystic fibrosis pigs.
- SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.
- Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism.
- Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice.
- Monocyte derived macrophages from CF pigs exhibit increased inflammatory responses at birth.
- The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases.
- Novel GP64 envelope variants for improved delivery to human airway epithelial cells.
- Long-term correction of hemophilia A mice following lentiviral mediated delivery of an optimized canine factor VIII gene.
- Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis.
- Bronchoscopic diagnosis of cytomegalovirus pneumonia following pediatric bone marrow transplantation.
- A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus.
- Normal sweat chloride values do not exclude the diagnosis of cystic fibrosis.
- A mouse model for the delta F508 allele of cystic fibrosis.
- Cystoplasty for treatment of a congenital lung cyst.
- Cloning, expression, and tissue distribution of a human amiloride-sensitive Na+ channel.
- Altered fluid transport across airway epithelium in cystic fibrosis.
- Spontaneous contractility of human fetal airway smooth muscle.
- Localization of epithelial sodium channel subunit mRNAs in adult rat lung by in situ hybridization.
- Proliferation induced by keratinocyte growth factor enhances in vivo retroviral-mediated gene transfer to mouse hepatocytes.
- Human airway epithelia express a beta-defensin.
- Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia.
- In-utero gene transfer--an approach to the treatment of inherited lung diseases.
- Ursodeoxycholic acid improves cholestasis in infants with cystic fibrosis.
- A classification scheme for paradoxical vocal cord motion.
- Effect of glutathione peroxidase activity on lipid peroxidation in biological membranes.
- Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.
- Effects of keratinocyte and hepatocyte growth factor in vivo: implications for retrovirus-mediated gene transfer to liver.
- Ultrasound-guided gene transfer to hepatocytes in utero.
- Influence of cell polarity on retrovirus-mediated gene transfer to differentiated human airway epithelia.
- Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.
- Developmental regulation of epithelial sodium channel subunit mRNA expression in rat colon and lung.
- Production of beta-defensins by human airway epithelia.
- Urinary bombesin-like peptide levels in infants and children with bronchopulmonary dysplasia and cystic fibrosis.
- Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia.
- Developmental expression of the epithelial Na+ channel in kidney and uroepithelia.
- Disruption of the beta subunit of the epithelial Na+ channel in mice: hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype.
Treatments
- Asthma
- Chronic Obstructive Pulmonary Disease (copd)
Dr. Paul B Mccray MD's Practice location
Practice At 200 Hawkins Dr
200 Hawkins Dr -Iowa City, IA 52242Get Direction
New patients: 319-356-3605, 319-356-4866, 319-356-2229
Fax: 319-356-3901, 319-356-7171
Dr. Paul B Mccray MD's reviews
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