Dr. Robert O Heuckeroth MD
Gastroenterologist (Pediatric) | Pediatric Gastroenterology1 Childrens Pl Saint Louis MO, 63110
Dr. Robert Heuckeroth is a pediatric gastroenterologist practicing in Saint Louis, MO. Dr. Heuckeroth specializes in digestive system, liver or nutritional problems in children from the newborn period to their teens. Conditions such as irritable bowel syndrome, lactose intolerance, chronic constipation or obesity can all be treated by a pediatric gastroenterologist.
Education and Training
Washington Univ Sch Of Med- St Louis Mo 1990
PediatricsAmerican Board of PediatricsABP
- Anomalous development of the hepatobiliary system in the Inv mouse.
- RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.
- GDNF availability determines enteric neuron number by controlling precursor proliferation.
- Finding your way to the end: a tale of GDNF and endothelin-3.
- Neurturin signalling via GFRalpha2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons.
- GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration.
- A human yeast artificial chromosome containing the multiple endocrine neoplasia type 2B Ret mutation does not induce medullary thyroid carcinoma but does support the growth of kidneys and partially rescues enteric nervous system development in Ret-de
- Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival.
- Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice.
- Getting to the guts of enteric nervous system development.
- Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis.
- BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition.
- Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis.
- Tissue-type plasminogen activator deficiency exacerbates cholestatic liver injury in mice.
- PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA.
- Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity.
- Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro.
- Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.
- The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.
- Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.
- Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice.
- Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis.
- Novel fatty acyl substrates for myristoyl-CoA:protein N-myristoyl-transferase.
- Hypothyroidism is a rare cause of isolated constipation.
- Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction.
- Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection.
- Enteric nervous system development: migration, differentiation, and disease.
- Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.
- Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.
- Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.
- Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis.
- Altered membrane association of p60v-src and a murine 63-kDa N-myristoyl protein after incorporation of an oxygen-substituted analog of myristic acid.
- Vascular and neural stem cells in the gut: do they need each other?
- Building a second brain in the bowel.
- Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury.
- Disruption of the yeast N-myristoyl transferase gene causes recessive lethality.
- Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.
- Hirschsprung's disease, Down syndrome, and missing heritability: too much collagen slows migration.
- Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse.
- Regeneration: Stem cells make the bowel nervous.
- Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention.
- Replication of human immunodeficiency virus 1 and Moloney murine leukemia virus is inhibited by different heteroatom-containing analogs of myristic acid.
- Analysis of the tissue-specific expression, developmental regulation, and linkage relationships of a rodent gene encoding heart fatty acid binding protein.
- Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation.
- The metabolic significance of mammalian fatty-acid-binding proteins: abundant proteins in search of a function.
- Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons.
- Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro.
- GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.
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Patient Experience with Dr. Heuckeroth
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