Dr. Karen W. Gripp MD
Geneticist | Clinical Genetics (M.D.)A. I. Dupont Hospital For Children 1600 Rockland Road Wilmington DE, 19803
Dr. Karen Gripp practices Genetic Medicine in Wilmington, DE. As a geneticist, Dr. Gripp performs experiments and analyzes data to interpret the inheritance of different traits in patients. A geneticist evaluates, diagnoses, and manages patients with hereditary conditions or congenital malformations, genetic risk calculations, and mutation analysis. Dr. Gripp carries out studies, tests, and counsels patients with genetic diseases.
Education and Training
Univ Hamburg, Krankenhaus Eppendorf, Fak Med, Hamburg 1989
Universitaet Hamburg, Fachbereich Medizin 1989
University of Hamburg / Medical Faculty Medicine
Medical GeneticsAmerican Board of Medical GeneticsABMG
PediatricsAmerican Board of PediatricsABP
DermatologyAmerican Board of DermatologyABD
- Second case of bladder carcinoma in a patient with Costello syndrome.
- Decreased elastin deposition and high proliferation of fibroblasts from Costello syndrome are related to functional deficiency in the 67-kD elastin-binding protein.
- Craniosynostosis: molecular testing-a necessity for counseling.
- Human chromosome 7: DNA sequence and biology.
- Genetics of colorectal cancer.
- 22q11.2 deletion syndrome and selective IgM deficiency: an association of a common chromosomal abnormality with a rare immunodeficiency.
- Adaptive skills, cognitive, and behavioral characteristics of Costello syndrome.
- Filamin A mutations cause periventricular heterotopia with Ehlers-Danlos syndrome.
- Observation of a parental inversion variant in a rare Williams-Beuren syndrome
- Tumor predisposition in Costello syndrome.
- Wilms tumor in an 11-year-old with hemihyperplasia.
- Paternal bias in parental origin of HRAS mutations in Costello syndrome.
- Longitudinal assessment of cognitive characteristics in Costello syndrome.
- Costello syndrome and related disorders.
- Clarification of previously reported Costello syndrome patients.
- Preaxial hallucal polydactyly as a marker for diabetic embryopathy.
- Male-to-male transmission of Costello syndrome: G12S HRAS germline mutation inherited from a father with somatic mosaicism.
- Prenatal features of Costello syndrome: ultrasonographic findings and atrial tachycardia.
- Longitudinal course of cognitive, adaptive, and behavioral characteristics in Costello syndrome.
- Living with Costello syndrome: quality of life issues in older individuals.
- Agenesis of the corpus callosum and congenital lymphedema: A novel recognizable syndrome?
- X-linked hereditary hemihypotrophy hemiparesis hemiathetosis.
- CNS imaging is a key diagnostic tool in the evaluation of patients with CFC syndrome: two cases and literature review.
- Clinical, pathological, and molecular analyses of cardiovascular abnormalities in Costello syndrome: a Ras/MAPK pathway syndrome.
- Cardio-facio-cutaneous syndrome: does genotype predict phenotype?
- Neurocognitive, adaptive, and behavioral functioning of individuals with Costello syndrome: a review.
- Lateral meningocele syndrome and Hajdu-Cheney syndrome: different disorders with overlapping phenotypes.
- Transmission of the rare HRAS mutation (c. 173C > T; p.T58I) further illustrates its attenuated phenotype.
- A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development.
- Normative growth charts for individuals with Costello syndrome.
- Cardiac anomalies in Axenfeld-Rieger syndrome due to a novel FOXC1 mutation.
- Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus.
- De novo truncating mutations in ASXL3 are associated with a novel clinical phenotype with similarities to Bohring-Opitz syndrome.
- Assessing genotype-phenotype correlation in Costello syndrome using a severity score.
- Exome analysis in clinical practice: expanding the phenotype of Bartsocas-Papas syndrome.
- Constitutional mismatch repair deficiency presenting in childhood as three
- Orthopedic manifestations and implications for individuals with Costello syndrome.
- Diamond-Blackfan anemia with mandibulofacial dystostosis is heterogeneous, including the novel DBA genes TSR2 and RPS28.
- Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype.
- Differentiating between copy-number-variation and gain-of-function mutation.
- Paternal uniparental disomy with segmental loss of heterozygosity of chromosome 11 are hallmark characteristics of syndromic and sporadic embryonal rhabdomyosarcoma.
- Attenuated phenotype of Costello syndrome and early death in a patient with an HRAS mutation (c.179G>T; p.Gly60Val) affecting signalling dynamics.
- Constitutional LZTR1 mutation presenting with a unilateral vestibular schwannoma in a teenager.
- A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affecting codon 146-Literature review and update.
- Phenotypic spectrum of Costello syndrome individuals harboring the rare HRAS mutation p.Gly13Asp.
- X-linked hypomyelination with spondylometaphyseal dysplasia (H-SMD) associated with mutations in AIFM1.
- Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.
- Apparently new syndrome of congenital cataracts, sensorineural deafness, Down
- Bilateral duplication of the primary ulnar ossification center in Ellis-van Creveld syndrome.
- Extending the spectrum of distal arthrogryposis.
- 2012 Philadelphia Super Doctors
- Children'S Hosp-Philadelphia, Medical Genetics; Thos Jefferson Univ Hosp, Pediatrics
- Jefferson University Hospitals
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Patient Experience with Dr. Gripp
- Ehlers-Danlos Syndrome: Symptoms, Causes, Diagnosis, and Treatment
What is Ehlers-Danlos syndrome (EDS)?Ehlers-Danlos syndrome (EDS) is a group of genetic disorders that affect the body’s connective tissues, which are proteins that support the blood vessels, skin, bones, and other organs in the body. Connective tissues also provide elasticity and strength to the...
- The History of Muscular Dystrophy
What is muscular dystrophy?Muscular dystrophy is an inherited disorder, which is often characterized by a progressive type of muscular degeneration and weakness. There are several types of muscular dystrophy, wherein each type eventually leads to an increased disability, strength loss, and potential...
- Is Pancreatic Cancer Genetic?
Is Pancreatic Cancer Genetic?Cancer is caused by a change in your genetic sequence. Genes are responsible for designing your body. Any alteration at that level will alter your body patterns.Cancer is an uncontrolled production of abnormal cells. Usually new cells are formed when your body needs...
- Different Types of Physicians Explained
Doctors or physicians are categorized according to different factors including medical specialties and subspecialties. Most doctors specialize in a specific area of medicine. This article provides a summary of the different types of doctors in the medical field. AllergistsAllergists are also...
- What Is Pituitary Dwarfism?
IntroductionPituitary dwarfism, also called growth hormone deficiency, is a medical condition wherein the pituitary gland does not produce sufficient amounts of growth hormone. This deficiency often results in children’s slow growth or short stature.An adult with pituitary dwarfism has an average...
- What Causes Albinism?
What is albinism?Albinism is a group of genetic disorders that cause little or no production of the natural pigment called melanin. The color of your skin, hair, and eyes depend on the type and amount of melanin produced by your body. Most individuals with albinism have sun sensitivity, which makes...
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