Dr. Geoffrey Wolfe Krystal M.D.
Oncologist | Medical Oncology
1201 Broad Rock Blvd Mcguire Veterans Aff Richmond VA, 23249Rating
5/5
About
Dr. Geoffrey Krystal is an oncologist practicing in Richmond, VA. Dr. Krystal specializes in the care and treatment of patients with cancer. As an oncologist, Dr. Krystal manages and oversees the treatment of a cancer patient after he or she has been diagnosed with the disease. Oncologists will care for their patients throughout the course of the disease. Types of oncologists include medical oncologists, surgical oncologists, radiation oncologists, gynecologic oncologists, pediatric oncologists and hematologist oncologists.
Education and Training
University of Miami Leonard M. Miller School of Medicine 1982
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors.
- Src family kinase activity is required for Kit-mediated mitogen-activated protein (MAP) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells.
- The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth.
- A novel assay for the measurement of Raf-1 kinase activity.
- Indolinone tyrosine kinase inhibitors block Kit activation and growth of small cell lung cancer cells.
- Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents.
- Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy.
- Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.
- Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.
- Role of small-molecule kit receptor tyrosine kinase inhibitors in the treatment of small-cell lung cancer.
- Imatinib mesylate (STI571) for myeloid malignancies other than CML.
- The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling.
- The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression.
- The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy.
- Inhibition of insulin/IGF-1 receptor signaling enhances bile acid toxicity in primary hepatocytes.
Treatments
- Prostate Cancer
- Anemia
- Lung Cancer
- Lymphoma
- Multiple Myeloma
- Leukemia
- Extra Corporeal Shockwave Therapy
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MEDICAL COLLEGE OF VIRGINIA HOSPITALSl
1250 EAST MARSHALL STREET - BOX 980510 RICHMOND VA 23298BON SECOURS RICHMOND COMMUNITY HOSPITALl
1500 N. 28TH STREET RICHMOND VA 23223