Dr. Horwitz is a UW Professor of Pathology and of Medicine, and Adjunct Professor of Genome Sciences. Dr. Horwitz is an internist and clinical medical geneticist whose research interests relate to genetic ...
Internal MedicineAmerican Board of Internal MedicineABIM
Medical GeneticsAmerican Board of Medical GeneticsABMG
- Differential chemokine induction by the mouse adenovirus type-1 in the central nervous system of susceptible and resistant strains of mice.
- Viruses, host responses, and autoimmunity.
- Regulation of the NF-kappaB activation pathway by isolated domains of FIP3/IKKgamma, a component of the IkappaB-alpha kinase complex.
- An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase.
- Pancreatic expression of interferon-gamma protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis.
- Adenovirus immunoregulatory genes and their cellular targets.
- DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.
- A critical role for inducible nitric oxide synthase in host survival following coxsackievirus B4 infection.
- The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell
- Requirements for viral-mediated autoimmune diabetes: beta-cell damage and immune infiltration.
- Synthesis and assembly of adenovirus polypeptides. III. Reversible inhibition of hexon assembly in adenovirus type 5 temperature-sensitive mutants.
- Sites on FIP-3 (NEMO/IKKgamma) essential for its phosphorylation and NF-kappaB modulating activity.
- Evolution of adenoviruses as gene therapy vectors.
- Inhibition of tumor necrosis factor alpha-induced NF-kappa B activation by the adenovirus E3-10.4/14.5K complex.
- Inhibition of chemokine expression by adenovirus early region three (E3) genes.
- UW - Division of General Internal Medicine
- UW - Dept. of Genetics
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- What is Neurofibromatosis?
Neurofibromatosis is a genetic disorder that affects the development of nerve cells and tissues in the body, leading to the formation of tumors in different parts of the nervous system. These tumors, also known as neurofibromas, may develop in the brain, spinal cord, along the nerves, or under the...
- What Is Pituitary Dwarfism?
IntroductionPituitary dwarfism, also called growth hormone deficiency, is a medical condition wherein the pituitary gland does not produce sufficient amounts of growth hormone. This deficiency often results in children’s slow growth or short stature.An adult with pituitary dwarfism has an average...
- Is Pancreatic Cancer Genetic?
Is Pancreatic Cancer Genetic?Cancer is caused by a change in your genetic sequence. Genes are responsible for designing your body. Any alteration at that level will alter your body patterns.Cancer is an uncontrolled production of abnormal cells. Usually new cells are formed when your body needs...
- The Function and Structure of DNA
Deoxyribonucleic acid or DNA is a molecule that contains the instructions an organism needs to develop, live and reproduce. These instructions are found inside every cell and are passed down from parents to their children.The Structure of DNADNA contains molecules called nucleotides, which possess a...
- Is My Child More Likely to Develop Autism if a Blood Relative Has Autism?
Autism characterized by impaired social interactions reduced verbal and non-verbal communication and stereotyped behavior and activities. These symptoms appear in early childhood and impair or limit everyday functioning.Autism and geneticsResearchers believe that both environment and genetics play a...
- Ehlers-Danlos Syndrome: Symptoms, Causes, Diagnosis, and Treatment
What is Ehlers-Danlos syndrome (EDS)?Ehlers-Danlos syndrome (EDS) is a group of genetic disorders that affect the body’s connective tissues, which are proteins that support the blood vessels, skin, bones, and other organs in the body. Connective tissues also provide elasticity and strength to the...
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