Dr. Richard G. Pestell M.D., PHD.
Oncologist | Medical Oncology
111 S 11th St Suite G4240 Philadelphia PA, 19107Rating
4/5
About
Dr. Richard Pestell is an oncologist practicing in Philadelphia, PA. Dr. Pestell specializes in the care and treatment of patients with cancer. As an oncologist, Dr. Pestell manages and oversees the treatment of a cancer patient after he or she has been diagnosed with the disease. Oncologists will care for their patients throughout the course of the disease. Types of oncologists include medical oncologists, surgical oncologists, radiation oncologists, gynecologic oncologists, pediatric oncologists and hematologist oncologists.
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells.
- pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-s
- BRCA1 inhibition of estrogen receptor signaling in transfected cells.
- Protein kinase Cdelta inhibition of S-phase transition in capillary endothelial cells involves the cyclin-dependent kinase inhibitor p27(Kip1).
- NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.
- Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA.
- The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation.
- Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway.
- p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity.
- Caveolin-1 potentiates estrogen receptor alpha (ERalpha) signaling. caveolin-1 drives ligand-independent nuclear translocation and activation of ERalpha.
- Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis.
- Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.
- The cyclin D1 gene is transcriptionally repressed by caveolin-1.
- Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1.
- Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression.
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