Dr. William E. Carson MD
Surgical Oncologist | Surgical Oncology1145 Olentangy River Rd Third Floor Columbus OH, 43212
Dr. William Carson is a surgical oncologist practicing in Columbus, OH. Dr. Carson specializes in diagnosing, staging and treating cancer-related symptoms. Surgical oncologists also decide if the patient is a candidate for surgery or other cancer treatments based on certain factors such as age, physical fitness and other possible coexisting medical conditions
Education and Training
Univ of Southern Ca Sch of Med, Los Angeles Ca 1986
SurgeryAmerican Board of SurgeryABS
- Molluscum contagiosum.
- A fatal cytokine-induced systemic inflammatory response reveals a critical role for NK cells.
- Costimulation of human natural killer cells is required for interferon gamma production.
- Human natural killer cells: a unique innate immunoregulatory role for the
- IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells.
- Intra-arterial administration of TNF-alpha followed by arterial ablation is an effective therapy for a regionally confined TNF-resistant rat mammary adenocarcinoma.
- A chimeric multi-human epidermal growth factor receptor-2 B cell epitope peptide vaccine mediates superior antitumor responses.
- Patterns of recurrence after sentinel lymph node biopsy for breast cancer.
- The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse.
- Griseofulvin therapy in chronic dermatophyte infections.
- MOLLUSCUM CONTAGIOSUM OF THE SOLE.
- IL-12 pretreatments enhance IFN-alpha-induced Janus kinase-STAT signaling and
- A phase I study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: analysis of sustained interferon gamma production in a subset of patients.
- Psychological, behavioral, and immune changes after a psychological intervention: a clinical trial.
- Multiparametric flow cytometric analysis of inter-patient variation in STAT1 phosphorylation following interferon Alfa immunotherapy.
- Expression of STAT1 and STAT2 in malignant melanoma does not correlate with response to interferon-alpha adjuvant therapy.
- Release of biologically functional interferon-alpha from a nanochannel delivery system.
- CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells.
- Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12.
- Novel cytokines in the treatment of malignancies.
- Getting melanoma cells to stimulate with frequency.
- Phase I study of the sequential combination of interleukin-12 and interferon alfa-2b in advanced cancer: evidence for modulation of interferon signaling pathways by interleukin-12.
- Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells.
- Interleukin-21 enhances NK cell activation in response to antibody-coated targets.
- TGF-beta inhibition of CTL re-stimulation requires accessory cells and induces peroxisome-proliferator-activated receptor-gamma (PPAR-gamma).
- Interferon alpha and CPG oligodeoxynucleotides elicit additive immunostimulatory and antitumor effects.
- Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments.
- Multiparametric flow cytometric analysis of signal transducer and activator of transcription 5 phosphorylation in immune cell subsets in vitro and following interleukin-2 immunotherapy.
- Impaired natural killer cell lysis in breast cancer patients with high levels of psychological stress is associated with altered expression of killer immunoglobin-like receptors.
- IFN-alpha-induced signal transduction, gene expression, and antitumor activity of
- Distress reduction from a psychological intervention contributes to improved health for cancer patients.
- STAT1-dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha.
- A randomized phase 2 trial of bevacizumab with or without daily low-dose interferon alfa-2b in metastatic malignant melanoma.
- Melanoma cells exhibit variable signal transducer and activator of transcription 1 phosphorylation and a reduced response to IFN-alpha compared with immune effector cells.
- The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor positive tumor cells is enhanced by cytokines.
- Current immunotherapeutic strategies in breast cancer.
- Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma.
- Activation of extracellular signaling regulated kinase in natural killer cells and monocytes following IL-2 stimulation in vitro and in patients undergoing IL-2 immunotherapy: analysis via dual parameter flow-cytometric assay.
- IFN-alpha-2b-induced signal transduction and gene regulation in patient peripheral blood mononuclear cells is not enhanced by a dose increase from 5 to 10 megaunits/m2.
- Immune, endocrine, and behavioral precursors to breast cancer recurrence: a case-control analysis.
- Biphasic anaphylactic reaction to blue dye during sentinel lymph node biopsy.
- VEGF secretion is inhibited by interferon-alpha in several melanoma cell lines.
- Gene expression profiling reveals similarities between the in vitro and in vivo responses of immune effector cells to IFN-alpha.
- IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis.
- Giant breast tumors: surgical management of phyllodes tumors, potential for reconstructive surgery and a review of literature.
- Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial.
- Bortezomib pre-treatment prolongs interferon-alpha-induced STAT1 phosphorylation in melanoma cells.
- A psychological intervention reduces inflammatory markers by alleviating depressive symptoms: secondary analysis of a randomized controlled trial.
- Phase I active immunotherapy with combination of two chimeric, human epidermal growth factor receptor 2, B-cell epitopes fused to a promiscuous T-cell epitope in patients with metastatic and/or recurrent solid tumors.
- A phase I trial of paclitaxel and trastuzumab in combination with interleukin-12 in patients with HER2/neu-expressing malignancies.
- Immune modulation with interleukin-21.
- Interleukin-29 binds to melanoma cells inducing Jak-STAT signal transduction and apoptosis.
- Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells.
- Folate-immunoglobulin G as an anticancer therapeutic antibody.
- A pilot study of bevacizumab and interferon-α2b in ocular melanoma.
- Biobehavioral, immune, and health benefits following recurrence for psychological
- The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.
- Braking bad: blockade of inhibitory pathways improves interleukin-15 therapy.
- IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ production.
- NK cell-based immunotherapy for treating cancer: will it be promising?
- Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients.
- Enhanced anti-tumor activity of interferon-alpha in SOCS1-deficient mice is mediated by CD4⁺ and CD8⁺ T cells.
- Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4⁺ T cells from patients with GI malignancy.
- A phase 2 trial of bevacizumab and high-dose interferon alpha 2B in metastatic melanoma.
- Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice.
- Impact of breast cancer recurrence and cancer-specific stress on spouse health and immune function.
- miR-21 and miR-155 are associated with mitotic activity and lesion depth of borderline melanocytic lesions.
- Suppression of canine myeloid cells by soluble factors from cultured canine tumor cells.
- Individualized local treatment strategies for in-transit melanoma.
- Review of complementary and alternative medicine and selected nutraceuticals: background for a pilot study on nutrigenomic intervention in patients with advanced cancer.
- Monoclonal antibody therapy of pancreatic cancer with cetuximab: potential for immune modulation.
- Cetuximab therapy in head and neck cancer: immune modulation with interleukin-12 and other natural killer cell-activating cytokines.
- β-Adrenergic receptor mediated increases in activation and function of natural killer cells following repeated social disruption.
- Review of S100A9 biology and its role in cancer.
- Immunotherapy with HER-2 and VEGF peptide mimics plus metronomic paclitaxel causes superior antineoplastic effects in transplantable and transgenic mouse models of human breast cancer.
- Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo.
- Correction to: Foy KC, Miller MJ, Moldovan N, Carson III WE, Kaumaya PTP. Combined vaccination with HER-2 peptide followed by therapy with VEGF peptide mimics exerts effective anti-tumor and anti-angiogenic effects in vitro and in vivo. OncoImmunolog
- Ex vivo expansion of canine cytotoxic large granular lymphocytes exhibiting characteristics of natural killer cells.
- Myeloid-derived suppressor cells in breast cancer.
- The role of IL-27 in the induction of anti-tumor cytotoxic T lymphocyte response.
- Metastatic melanoma: lactate dehydrogenase levels and CT imaging findings of tumor devascularization allow accurate prediction of survival in patients treated with bevacizumab.
- Cytokine signaling-1 suppressor is inducible by IL-1beta and inhibits the catabolic effects of IL-1beta in chondrocytes: its implication in the paradoxical joint-protective role of IL-1beta.
- A phase I trial of bortezomib and interferon-α-2b in metastatic melanoma.
- Signaling pathways involved in MDSC regulation.
- Myeloid derived suppressor cells - a new therapeutic target in the treatment of cancer.
- Patients with pancreatic adenocarcinoma exhibit elevated levels of
- RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment.
- MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor.
- Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.
- Tumor Infiltrating Lymphocytes - The Next Step in Assessing Outcome and Response to Treatment in Patients with Breast Cancer.
- The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells.
- Predicting Overall Survival in Patients With Metastatic Melanoma on Antiangiogenic Therapy and RECIST Stable Disease on Initial Posttherapy Images Using CT Texture Analysis.
- Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology.
- Surgical management of ovarian carcinoma metastatic to the breast and axilla: A role for metastasectomy?
- Gene expression profiling of the human natural killer cell response to Fc receptor activation: unique enhancement in the presence of interleukin-12.
- ASCO 2015 update on melanoma.
- MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies.
- Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fcγ Receptor (FcγR) Function.
- Increased visceral to subcutaneous fat ratio is associated with decreased overall survival in patients with metastatic melanoma receiving anti-angiogenic therapy.
- A Comprehensive Program for the Enhancement of Accrual to Clinical Trials.
- NK Cell-Mediated Antitumor Effects of a Folate-Conjugated Immunoglobulin Are Enhanced by Cytokines.
- Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and Can Be Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment.
- Structural characterization of NRAS isoform 5.
- Folate-conjugated immunoglobulin targets melanoma tumor cells for NK cell effector functions.
- A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.
- Trajectories of Stress, Depressive Symptoms, and Immunity in Cancer Survivors: Diagnosis to 5 Years.
- IL-21 Enhances Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells.
- Classification of Indeterminate Melanocytic Lesions by MicroRNA Profiling.
- MicroRNA dysregulation in melanoma.
- Global microRNA profiling for diagnostic appraisal of melanocytic Spitz tumors.
- MicroRNA profiling of patient plasma for clinical trials using bioinformatics and
- The combination of MLN2238 (ixazomib) with interferon-alpha results in enhanced cell death in melanoma.
- Targeting tissue factor as a novel therapeutic oncotarget for eradication of cancer stem cells isolated from tumor cell lines, tumor xenografts and patients of breast, lung and ovarian cancer.
- Fluorescent nanodiamonds engage innate immune effector cells: A potential vehicle for targeted anti-tumor immunotherapy.
- Plasma MicroRNA Levels Following Resection of Metastatic Melanoma.
- Novel rodent model of breast cancer survival with persistent anxiety-like behavior and inflammation.
- Circulating myeloid-derived suppressor cells increase in patients undergoing neo-adjuvant chemotherapy for breast cancer.
- MICA-Expressing Monocytes Enhance Natural Killer Cell Fc Receptor-Mediated Antitumor Functions.
- Identification of NRAS isoform 2 overexpression as a mechanism facilitating BRAF inhibitor resistance in malignant melanoma.
- Nitric oxide mediated inhibition of antigen presentation from DCs to CD4 T cells in cancer and measurement of STAT1 nitration.
- Linear porokeratosis of Mibelli.
- The functional characterization of interleukin-10 receptor expression on human natural killer cells.
- The c-kit ligand potentiates the allogeneic mixed lymphocyte reaction.
- Interleukin 15: a potential player during the innate immune response to infection.
- Stem cell factor enhances interleukin-2-mediated expansion of murine natural killer cells in vivo.
- Paget's disease of the breast: a 33-year experience.
- Interferon-alpha-induced activation of signal transducer and activator of transcription proteins in malignant melanoma.
- Flt3 ligand promotes the generation of a distinct CD34(+) human natural killer cell progenitor that responds to interleukin-15.
- Univ Ca Irvine Med Ctr, General Surgery
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