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Dr. Daniel Penello, MD, MBA, Hand Surgeon | Surgery of the Hand
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Dr. Daniel Penello, MD, MBA

Hand Surgeon | Surgery of the Hand

12416 66th St Suite A Largo FL, 33773



Dr. Penello is and Orthopaedic Surgeron with subspecialty training in treating dosrders of the Hand, Wrist and Elbow. He graduated summa cum laude with a Bachelor of Science in Kinesiology at York University in Toronto, Canada. He earned his medical degree from The University of Toronto with honors in 2002. He was admitted to the esteemed Alpha Omega Alpha Honor Medical Society. He then completed his internship and Orthopaedic Surgery Residency at The University of Toronto where he was recognized for his academic achievement and teaching ability. This garnered him several awards, such as the Humanitarianism award and the prestigious Top Doctor Award in 2012 and in 2020 for surgery of the Hand and Upper Extremity.

His dedication to health policy, process improvement and commercialization of medical devices led him to receive a Health Sector MBA at The Rotman School of Management in Toronto during his residency. He then completed a Hand and Upper Extremity Fellowship at The Cleveland Clinic Foundation, in Cleveland, Ohio.

Dr. Penello has been involved with numerous research projects. He has also authored and co-authored publications in the United States and Canada.

Education and Training

York University BSc Kinesiology 1995

The Cleveland Clinic Hand Surgery Specialist 2010

Univ Of Toronto Fac Of Med 2002

University Of Toronto Faculty Of Medicine 2002

Board Certification

American Board of Orthopaedic Surgery

Surgery of the Hand (Orthopaedic Surgery)

Provider Details

Male English, Italian
Dr. Daniel Penello, MD, MBA
Dr. Daniel Penello, MD, MBA's Expert Contributions
  • Will I be sedated during my hand surgery?

    Hello, The anesthetic plan is based upon your specific medical situation, and a discussion between yourself, the anesthesiologist, and the surgeon. However, generally speaking most hand surgeries are performed using a regional anesthetic combined with IV sedation rather than general anesthesia. Certain minor procedures may be performed under local anesthesia only without the need for sedation. Daniel READ MORE

  • What is the best way to recover following wrist surgery?

    Hello, Thank you for your question. There are many types of wrist surgeries and the recovery process for each one can be very different. For example, recovery following a carpal tunnel release is very different than recovering from repair of a broken bone or torn ligament. Is there a particular type of wrist surgery you are inquiring about? It would be important to keep your hand elevated, manage your pain appropriately, eat a healthy diet, and follow your surgeon's postoperative instructions carefully. Daniel READ MORE

  • What type of anesthesia is used for hand nerve surgery?

    Thank you for your question. In most cases, hand nerve surgery such as digital nerve repair, and carpal tunnel release can be done under local anesthesia. That is, local anesthetic is injected into the hand so you do not feel the procedure but remain awake and alert. Occasionally, patients may wish to receive some IV sedation (so they are not aware of what is happening g) as well, but that is optional. Daniel READ MORE

  • What is the best surgery for hand spasms?

    Hello, There are many different causes of hand spasms. An internal medicine specialist can evaluate for medical conditions that may be treatable with medications or Botox. From a hand surgery perspective, compressed nerves, either due to carpal tunnel syndrome, cubital tunnel syndrome, or a pinched nerve in the neck can also cause occasional hand spasms. In these cases, nerve decompression surgery in the appropriate location ( wrist, elbow, neck) can be helpful. The first step is establishing a diagnosis and understanding why the spasms are occurring. Daniel READ MORE

  • How long does hand surgery take under anesthesia?

    Hello, There are MANY types of hand surgeries which vary in length depending on the specific condition being treated. Carpal Tunnel Release surgery takes less than 15 minutes of actual surgical time. However, patients are asked to arrive about 60 minutes before their scheduled surgery, and are observed in the recovery room after surgery for a variable amount of time before being discharged. In all, the entire surgical experience for a simple surgery such as a Carpal Tunnel Release is approximately 3 hours. READ MORE

  • Are men and women are at equal risk for developing carpal tunnel syndrome?

    Hello, That’s a great question. Research has consistently demonstrated that women are at greater risk for developing carpal tunnel syndrome compared to men. Possible reasons include smaller carpal tunnel/wrist diameters, as well as hormonal changes that can influence fluid balance within the body. Sincerely, Daniel Penello READ MORE

Areas of expertise and specialization

Hand, Wrist, Elbow and Arm Disorders. Carpal Tunnel Syndrome, Tendonitis, Arthritis, Sprains, Nerve disorders

Faculty Titles & Positions

  • Teaching Faculty USF Orthopaedic Residency Program at Largo Medical Center 2011 - Present


  • Top Doctor - Hand Surgeon 2012 Top Doctors USA 
  • Top Doctor - Hand Surgeon 2020 Top Doctors USA 
  • Sopman Humanitarian Award 2003 University of Toronto 
  • Harris Award for Academic Achievement 2009 University of Toronto 


  • Chronic Pain
  • Trigger Finger
  • Peripheral Neuropathy
  • Carpal Tunnel Syndrome
  • Neuropathy
  • Pain
  • Ganglion Cyst
  • Tennis Elbow

Professional Memberships


Charities and Philanthropic Endeavors

  • All Children's Hospital Foundation
  • Alpha House
  • Ready for Life Pinellas

Areas of research

Peripheral Nerve Compression

Carpal Tunnel Syndrome

3D Printed Impant Technology

Dr. Daniel Penello, MD, MBA's Practice location

Daniel Penello

12416 66th St Suite A -
Largo, FL 33773
Get Direction
New patients: 727-547-4700
Fax: 727-394-8661

Alexander Orthopaedic Associates

2438 Dr. Martin Luther King Jr. St. N -
St. Petersburg, FL 33704
Get Direction
New patients: 727-547-4700

Dr. Daniel Penello, MD, MBA's reviews

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Patient Experience with Dr. Penello


Based on 1 reviews

Dr. Daniel Penello, MD, MBA has a rating of 5 out of 5 stars based on the reviews from 1 patient. FindaTopDoc has aggregated the experiences from real patients to help give you more insights and information on how to choose the best Hand Surgeon | Surgery of the Hand in your area. These reviews do not reflect a providers level of clinical care, but are a compilation of quality indicators such as bedside manner, wait time, staff friendliness, ease of appointment, and knowledge of conditions and treatments.
  • Anonymous

    Great Doctor.

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Head south on 66th Street North (FL 693) 4355 ft
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Turn right onto US 19 Southbound Frontage Road 1.4 mi
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201 14TH ST SW LARGO FL 33770

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