Dr. Jeffrey W Innis MD
Pediatrician1500 E Medical Center Dr 1st Floor Taubman Ct Ann Arbor MI, 48109
Dr. Jeffrey Innis is a pediatrician practicing in Ann Arbor, MI. Dr. Innis is a doctor who specializes in the health care of children. As a pedicatrician, Dr. Innis diagnoses and treats infections, injuries, diseases and other disorders in children. Pediatricians typically work with infants, children, teenagers and young adults up to age 21. They practice medical care as well as preventative health care. Dr. Innis can oversee and manage the physical, mental and emotional health of their patients.
Education and Training
University of Miami Leonard M. Miller School of Medicine 1985
Medical GeneticsAmerican Board of Medical GeneticsABMG
PediatricsAmerican Board of PediatricsABP
- Altered Hox expression and increased cell death distinguish Hypodactyly from Hoxa13 null mice.
- Infertility in adult hypodactyly mice is associated with hypoplasia of distal reproductive structures.
- Building arms or legs with molecular models.
- Severe limb defects in Hypodactyly mice result from the expression of a novel, mutant HOXA13 protein.
- Evolution of N-terminal sequences of the vertebrate HOXA13 protein.
- Familial syndromic esophageal atresia maps to 2p23-p24.
- eSAGE: managing and analysing data generated with serial analysis of gene expression (SAGE).
- Identification and prevention of a GC content bias in SAGE libraries.
- A comparative molecular analysis of developing mouse forelimbs and hindlimbs using serial analysis of gene expression (SAGE).
- Priming the search for HOX mutations.
- Possible third case of Lin-Gettig syndrome.
- Integrative biology and the developing limb bud.
- Juberg-Hayward syndrome: report of a new patient with severe phenotype and novel clinical features.
- Microcephaly, jejunal atresia, aberrant right bronchus, ocular anomalies, and XY sex reversal.
- Tibial aplasia, lower extremity mirror image polydactyly, brachyphalangy, craniofacial dysmorphism and genital hypoplasia: further delineation and mutational analysis.
- Polyalanine expansion in HOXA13: three new affected families and the molecular consequences in a mouse model.
- Two patients with monomelic ulnar duplication with mirror hand polydactyly: segmental Laurin-Sandrow syndrome.
- Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication.
- Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
- Candidate downstream regulated genes of HOX group 13 transcription factors with and without monomeric DNA binding capability.
- Phenotypic heterogeneity in the presentation of D-2-hydroxyglutaric aciduria in monozygotic twins.
- Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability.
- A genomic approach to the identification and characterization of HOXA13 functional binding elements.
- A group 13 homeodomain is neither necessary nor sufficient for posterior prevalence in the mouse limb.
- Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations.
- A heat-labile factor promotes premature 3' end formation in exon 1 of the murine adenosine deaminase gene in a cell-free transcription system.
- A mouse transgene drives embryonic dorsal posterior commissure expression.
- Molecular characterization of HOXA13 polyalanine expansion proteins in hand-foot-genital syndrome.
- BAC transgenic analysis reveals enhancers sufficient for Hoxa13 and neighborhood gene expression in mouse embryonic distal limbs and genital bud.
- Expanded HOXA13 polyalanine tracts in a monotreme.
- Further delineation of the 15q13 microdeletion and duplication syndromes: a clinical spectrum varying from non-pathogenic to a severe outcome.
- The murine adenosine deaminase promoter requires an atypical TATA box which binds transcription factor IID and transcriptional activity is stimulated by multiple upstream Sp1 binding sites.
- Sequence requirements for transcriptional arrest in exon 1 of the human adenosine deaminase gene.
- Multiple congenital anomalies and developmental delay in a boy associated with a de novo 16p13.3 deletion.
- Exome capture and massively parallel sequencing identifies a novel HPSE2 mutation in a Saudi Arabian child with Ochoa (urofacial) syndrome.
- Identification of two novel CAKUT-causing genes by massively parallel exon resequencing of candidate genes in patients with unilateral renal agenesis.
- Chromosome 4q deletion syndrome: narrowing the cardiovascular critical region to 4q32.2-q34.3.
- Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation.
- Maternal intrachromosomal insertional translocation leads to recurrent 1q21.3q23.3 deletion in two siblings.
- Analysis of de novo HOXA13 polyalanine expansions supports replication slippage without repair in their generation.
- ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling.
- Human HOX gene disorders.
- Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies.
- A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.
- Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations.
- Chromosomal Imbalances in Patients with Congenital Cardiac Defects: A Meta-analysis Reveals Novel Potential Critical Regions Involved in Heart Development.
- Nine de novo duplications affecting both maternal and paternal chromosomes and an inherited 15q11.2 deletion, in a patient with developmental delay.
- Recurrent deletions and duplications of chromosome 2q11.2 and 2q13 are associated with variable outcomes.
- Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort.
- Role of specific simian virus 40 sequences in the nuclease-sensitive structure in viral chromatin.
- DNA replication and chromatin structure of simian virus 40 insertion mutants.
- Chromatin structure of simian virus 40-pBR322 recombinant plasmids in COS-1 cells.
- Functional analysis of a stable transcription arrest site in the first intron of the murine adenosine deaminase gene.
- Characterization of 12 silent alleles of the human butyrylcholinesterase (BCHE) gene.
- The molecular basis of hypodactyly (Hd): a deletion in Hoxa 13 leads to arrest of digital arch formation.
- An efficient method for isolating putative promoters and 5'-transcribed sequences from large genomic clones.
- Mutation of HOXA13 in hand-foot-genital syndrome.
- Of fingers, toes and penises.
- Role of HOX genes in human development.
- Apparently new syndrome of sensorineural hearing loss, retinal pigment epithelium lesions, and discolored teeth.
- Septo-optic dysplasia and WS1 in the proband of a WS1 family segregating for a novel mutation in PAX3 exon 7.
- Limb development: molecular dysmorphology is at hand!
- Birth Defects
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