Dr. Michael B Kastan MD
Radiation Oncologist | Radiation Oncology
2100 Erwin Rd Durham NC, 27705About
Dr. Michael Kastan practices Radiation Oncology in Durham, NC. Radiation oncology is a medical specialty that involves treating cancer with radiation. Dr. Kastan specializes in treating cancer with radiation, using radiation therapy to treat a wide variety of cancers. Radiation therapy uses carefully targeted and regulated doses of high-energy radiation to kill cancer cells.
Education and Training
Washington Univ Sch Of Med- St Louis Mo 1984
Board Certification
DermatologyAmerican Board of DermatologyABD- 1997
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1.
- Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c.
- Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: structure-function analysis.
- Molecular determinants of sensitivity to antitumor agents.
- Substrate specificities and identification of putative substrates of ATM kinase family members.
- Ionizing radiation activates the ATM kinase throughout the cell cycle.
- ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
- Expression and assay of recombinant ATM.
- Cancer. A radical approach to treatment.
- Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.
- The many substrates and functions of ATM.
- Cell cycle. Checking two steps.
- Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing
- ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by
- ATM: genome stability, neuronal development, and cancer cross paths.
Fellowships
- Johns Hopkins Hospital, Pediatric Hematology-Oncology, Maryland, USA 1989
- Pediatric Hematology-Oncology, Johns Hopkins Hospital (Maryland) 1986
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