Dr. Gordon D Luk M.D.
Gastroenterologist | Gastroenterology1600 Central Dr #310 Bedford TX, 76022
Dr. Gordon Luk, MD is one of the country's top rated doctors, specializing in gastroenterology. MD Luk currently practices medicine at Bedford, Texas. Dr. Luk is a graduate of Harvard Medical School and ...
Education and Training
Harvard Med Sch, Boston Ma 1975
Harvard Medical School 1975
Internal MedicineAmerican Board of Internal MedicineABIM- Gastroenterology
- Use of structural equation modeling to test the construct validity of a case definition of Gulf War syndrome: invariance over developmental and validation samples, service branches and publicity.
- Detection of ornithine decarboxylase messenger RNA in human hepatocellular carcinoma by in situ hybridization.
- Failure of rectal ornithine decarboxylase to identify adenomatous polyp status.
- Taurine deficiency after intensive chemotherapy and/or radiation.
- Polyamine levels, ornithine decarboxylase (ODC) activity, and ODC-mRNA expression in normal and cancerous human colonocytes.
- Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells.
- Gastric epithelial cell proliferation after injury.
- Gastrointestinal neuropeptides suppress human colonic lamina propria lymphocyte DNA synthesis.
- Essential role for polyamine biosynthesis in thyroxine stimulated pancreatic development in neonatal rats.
- Supplemental calcium suppresses colonic mucosal ornithine decarboxylase activity in elderly patients with adenomatous polyps.
- The inhibition effect of cholecystokinin in human colonic lamina propria lymphocyte proliferation, and reversal by the cholecystokinin receptor antagonist L-364718.
- Beta-casomorphin (BCM) and human colonic lamina propria lymphocyte proliferation.
- Epidermal growth factor regulation of DNA synthesis in human colonic lamina propria lymphocytes.
- Differential activation of ornithine decarboxylase and tyrosine kinase in the rectal mucosa of patients with hyperplastic and adenomatous polyps.
- Effect of gastric mucosal injury on ornithine decarboxylase in young and aged rats.
- Polyamines in intestinal growth.
- Inhibition of DNA synthesis in human peripheral and lamina propria lymphocytes by 5-aminosalicylic acid and hydrocortisone.
- Induction of gastric mucosal cell proliferation by the fungicide captan: role of tyrosine kinases.
- Thymosin alpha 1 and thymosin beta 4 modulate human colonic lamina propria lymphocyte function.
- Combination of flavone acetic acid (FAA) with adriamycin, cis-platinum and difluoromethylornithine (DFMO) in vitro against human colon cancer cells.
- Modulation of human colonic lamina propria lymphocyte proliferation. Effect of bile acids and oxidized fatty acids.
- Isolation and expression of a human ornithine decarboxylase gene.
- Diacetylputrescine and its analog suppress c-myc expression and activation of human B-lymphocytes.
- Aging and intestinal polyamine metabolism in the rat.
- Cellular levels of thymosin immunoreactive peptides are linked to proliferative events: evidence for a nuclear site of action.
- Flavone acetic acid suppresses human peripheral blood lymphocyte and human colonic lamina propria lymphocyte DNA synthesis.
- Efficacy of screening flexible sigmoidoscopy for colorectal neoplasia in asymptomatic subjects.
- Prevention of colon cancer in primary care practice.
- Modulation of epidermal growth factor-induced cell proliferation and receptor binding by insulin in cultured intestinal epithelial cells.
- Biochemical changes in the gastric mucosa after injury in young and aged rats.
- Abnormal methylation of the calcitonin gene in human colonic neoplasms.
- Attenuation of azoxymethane-induced colonic mucosal ornithine decarboxylase and tyrosine kinase activity by calcium in rats.
- The growth-inhibitory effect of 4-hydroperoxycyclophosphamide against human non-small cell lung carcinoma is enhanced by low-dose difluoromethylornithine.
- Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
- Anchorage dependency effects on difluoromethylornithine cytotoxicity in human lung carcinoma cells.
- Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.
- Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.
- mRNA from human colon tumor and mucosa related to the pol gene of an endogenous A-type retrovirus.
- Cytotoxic response of the relatively difluoromethylornithine-resistant human lung tumor cell line NCI H157 to the polyamine analogue N1,N8-bis(ethyl)spermidine.
- Clinical features, evaluation, and detection of colorectal cancer.
- Life after colectomy.
- Strategies for the control of colorectal cancer.
- Essential role of polyamine metabolism in hepatic regeneration. Inhibition of deoxyribonucleic acid and protein synthesis and tissue regeneration by difluoromethylornithine in the rat.
- Polyamines and the synthesis of estradiol-regulated growth factors in rat mammary cancer in culture.
- Phase I trial and pharmacokinetic study of intravenous and oral alpha-difluoromethylornithine.
- Polyamines in normal and cancer cells.
- Polyamines in intestinal and pancreatic adaptation.
- Alpha-difluoromethylornithine-induced inhibition of growth of autochthonous
- Colorectal cancer. Scope of the problem.
- Distribution of polyamines and their biosynthetic enzymes in intestinal adaptation.
- Increased risk of cancer in the Peutz-Jeghers syndrome.
- Kinetic changes in mucosal ornithine decarboxylase activity during azoxymethane-induced colonic carcinogenesis in the rat.
- Congenital diarrhea with intestinal inflammation and epithelial immaturity.
- Colonic polyps and acrochordons (skin tags) do not correlate in familial colonic polyposis kindreds.
- Polyamines in biology and medicine.
- Same questions, different answers.
- Same questions, different answers.
- Cimetidine and impaired renal function.
- Cimetidine and impaired renal function.
- Screening for steatorrhea.
- Screening for steatorrhea.
- Origins of the crossed olivocochlear bundle shown by an acid phosphatase method in the cat.
- Regulation of hematopoiesis II: the role of polyamine inhibition on helper or suppressor influences of the thymus.
- Effects of dibutyryl cyclic adenosine 3':5'-monophosphate on the growth of cultured human small-cell lung carcinoma and the specific cellular activity of L-dopa decarboxylase.
- Plasma postheparin diamine oxidase. Sensitive provocative test for quantitating length of acute intestinal mucosal injury in the rat.
- Successful treatment with DL-alpha-difluoromethylornithine in established human small cell variant lung carcinoma implants in athymic mice.
- Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.
- Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.
- Inhibition of intestinal epithelial DNA synthesis and adaptive hyperplasia after jejunectomy in the rat by suppression of polyamine biosynthesis.
- Polyamines and intestinal growth: absolute requirement for ODC activity in adaptation during lactation.
- Polyamines and intestinal growth--increased polyamine biosynthesis after jejunectomy.
- Ornithine decarboxylase as a biologic marker in familial colonic polyposis.
- Diamine oxidase (histaminase). A circulating marker for rat intestinal mucosal maturation and integrity.
- Diamine oxidase as a plasma marker of rat intestinal mucosal injury and regeneration after administration of 1-beta-D-arabinofuranosylcytosine.
- Intestinal ischemia and diamine oxidase activity.
- Growth-inhibitory effects of DL-alpha-difluoromethylornithine in the spectrum of human lung carcinoma cells in culture.
- Multiclonal origin of polyps in Gardner syndrome.
- Prophylaxis against acute stress erosions.
- Diagnosis and therapy of hereditary polyposis syndromes.
- Analysis of ODC and c-myc gene expression in hepatocellular carcinoma by in situ hybridization and immunohistochemistry.
- Neuropeptide Y (NPY) enhances proliferation of human colonic lamina propria lymphocytes.
- Rolling review: gastrointestinal malignancy.
- Mucosal origin and shedding of an early colonic tumor marker defined by Adnab-9 monoclonal antibody.
- A defined collagen substrate and nutrient diffusion gradient culture system allows human colon cancer cells to assume a more differentiated phenotype.
- Inhibition of ornithine decarboxylase activity decreases polyamines and suppresses DNA synthesis in human colonic lamina propria lymphocytes.
- ODC activity and polyamine levels in isolated human colonocytes.
- Transformation of NIH/3T3 cells by ornithine decarboxylase overexpression.
- Prevention of gastrointestinal cancer--the potential role of NSAIDs in colorectal cancer.
- Zollinger-Ellison syndrome, acromegaly, and colorectal neoplasia.
- Effect of thyroxine on pancreatic digestive enzymes and ornithine decarboxylase gene expression in neonatal rats.
- Early weaning induces jejunal ornithine decarboxylase and cell proliferation in neonatal rats.
- Effect of spermine administration on pancreatic maturation in unweaned rats.
- Acid Reflux
- Vascular Disease
- Johns Hopkins Hosp, Gastroenterology; Johns Hopkins Hosp, Internal Medicine
- Johns Hopkins Bloomberg School of Public Health Program A
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Patient Experience with Dr. Luk
- What Is Hematochezia?
Introduction Discovering blood after a bowel movement can be a frightening experience. If you notice a bright red to black-colored blood in your stool, in the toilet bowl, or on the toilet paper, you may be experiencing rectal bleeding. Having blood in your stool does not always signal a serious...
- Psychological Changes in Children May Be a Sign of Celiac Disease
Celiac is an autoimmune, chronic disease of the gastrointestinal tract that is not easy to diagnose in adults. So, it is no surprise that things are even more complicated at an early age.However, a timely diagnosis of autoimmune disorders is critical, considering the fact that an early on-set...
- Firefighters from Around the World Take Steps Toward Cystic Fibrosis Research
As a firefighter, Wes Loucks received countless emergency phone calls throughout his 32 years of service for the Portland Fire and Rescue Bureau. After retiring, he received a personal call for help from his own family. His two grandsons were both born with cystic fibrosis (CF), a chronic genetic...
- Does Celiac Disease Impact Hair Growth?
As celiac disease (CD) continues to be a hot topic, more people are becoming to understand its many symptoms. Everyone knows that CD can cause gastrointestinal problems, headaches, skin issues, and weight loss. But, with all the ‘common’ and well-known symptoms, there is also a few not-so-well...
- What is C. Diff Infection?
There are thousands of species of harmless and useful bacteria residing in our digestive system, and they normally maintain a balance among themselves. If the balance is thrown off track, these good bacteria can cause a number of illnesses. One such bacterium in our gut is Clostridium difficile (C....
- What Are Ketones?
Almost every cell in the body has a primary source of energy, which is usually glucose. However, when the body doesn't have enough glucose, the liver responds by producing chemicals known as ketones, converting stored fatty acids into ketone bodies. Ketones are used as a backup fuel source when...
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