Dr. Damian Krysan is a pediatric infectious disease specialist practicing in Rochester, NY. Dr. Krysan specializes in recurring or persistent diseases caused by bacteria, parasites or fungus in infants, children and adolescents. Pediatric infectious disease specialists also provide consultation to other health care professionals dealing with complex cases.
Education and Training
University of Michigan Medical School 2000
PediatricsAmerican Board of PediatricsABP- Pediatric Infectious Diseases
- Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides.
- Synthesis of peptidyl methylcoumarin esters as substrates and active-site titrants for the prohormone processing proteases Kex2 and PC2.
- Renal transplantation after Streptococcus pneumoniae-associated hemolytic uremic syndrome.
- Reevaluating the efficacy of naturopathic ear drops.
- Precursor processing by kex2/furin proteases.
- Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin.
- Effectiveness over time of varicella vaccine.
- Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.
- Unconventional genomic architecture in the budding yeast saccharomyces cerevisiae masks the nested antisense gene NAG1.
- Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast.
- A high-throughput screening assay for small molecules that disrupt yeast cell integrity.
- The unfolded protein response is induced by the cell wall integrity
- Live Candida albicans suppresses production of reactive oxygen species in
- Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization.
- The cell wall and endoplasmic reticulum stress responses are coordinately regulated in Saccharomyces cerevisiae.
- A high-throughput assay of yeast cell lysis for drug discovery and genetic
- Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae.
- Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules.
- Age and symptoms affect the prevalence of group A beta-hemolytic streptococcus in pharyngeal cultures of school-age children.
- A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms.
- A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis.
- Optically active 2-ethenyl-1,3-dioxolanones as 3-carbon synthons. Allylnickel
- The RAM network in pathogenic fungi.
- Antifungal drug discovery: something old and something new.
- Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes.
- A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.
- Candida albicans morphogenesis is not required for macrophage interleukin 1β production.
- Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.
- Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF
- Antifungal drug development: challenges, unmet clinical needs, and new approaches.
- Catching fire: Candida albicans, macrophages, and pyroptosis.
- Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis.
- Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.
- Unraveling the biology of a fungal meningitis pathogen using chemical genetics.
- Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs.
- Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen.
- A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.
- Voriconazole Therapeutic Drug Monitoring.
- High-Throughput Screen in Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling.
- Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.
- Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans.
- Challenges in the development of novel anticryptococcal agents.
- The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
- The unmet clinical need of novel antifungal drugs.
- Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo.
- Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency.
- Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity.
Dr. Damian J Krysan MD's Practice location
Rochester, NY 14642Get Direction
IOWA CITY, IA 52242Get Direction
Dr. Damian J Krysan MD's reviewsWrite Review
- How is Cholera Diagnosed?
How is Cholera Diagnosed?Cholera is an acute bacteria disease caused by a bacterium called Vibrio cholerae. Infection with the cholera bacteria can lead to severe vomiting and diarrhea and finally electrolyte loss or dehydration. If not treated, cholera can, in many cases, result in death.In order...
- What Is Diarrhea: Get the Facts
Diarrhea is a very common water-borne disease. A person who has diarrhea passes loose or liquid stool at least three times a day or more frequently than what is normal for the person. The reason behind the consistency and frequency of these bowel movements in a case of diarrhea is the increased flow...
- Does the Pertussis Vaccine Have Any Contraindications and Side Effects?
Pertussis is an infection of the upper respiratory system. The disease is highly contagious and spreads through the coughing and sneezing of an infected individual. This highly contagious and airborne disease is caused by the bacteria called Bordetella pertussis. The symptoms of pertussis typically...
- What Team of Specialists Should I Contact if I Have Meningitis?
As complex as it is, meningitis can sometimes be a threat to life. Treating meningitis can be tricky, hence, it needs a team of medical practitioners to make a diagnosis and offer treatment for the condition. You can call your doctor immediately under the following circumstances:...
- What if I Do Not Want My Child to Undergo MMR Vaccination?
The MMR (measles, mumps, and rubella) vaccine is recommended for all children as it is the safest, most effective way to protect children against three diseases that can have serious, even fatal, consequences. Measles is a highly contagious viral infection whose initial symptoms include fever,...
- What to Expect on Your Future Visits to the Doctor After You Have Been Diagnosed with Lyme Disease
A diagnosis of Lyme disease immediately calls for a 2-4 week course of antibiotics. Doxycycline, amoxicillin, and cefuroxime axetil are some of the antibiotics most commonly used to treat Lyme disease. However, treatment may still vary depending on the symptoms present and the stage at which the...
- Dr. Julianne V Green MD601 Elmwood Ave Rochester NY 14642
- Dr. Francis Gigliotti MD601 Elmwood Ave Rochester NY 14642
- Dr. Melanie A Wellington MD601 Elmwood Ave Rochester NY 14642
- Dr. Cynthia Christy M.D.1425 Portland Ave Rochester NY 14621
- Dr. Mary T Caserta MD601 Elmwood Ave Rochester NY 14642
- Dr. Karl oliver Ang Yu M.D., PH.D.5841 S Maryland Ave Chicago IL 60637