Dr. Damian J Krysan MD
Infectious Disease Specialist (Pediatric) | Pediatric Infectious Diseases
601 Elmwood Ave Box 635 Rochester NY, 14642About
Dr. Damian Krysan is a pediatric infectious disease specialist practicing in Rochester, NY. Dr. Krysan specializes in recurring or persistent diseases caused by bacteria, parasites or fungus in infants, children and adolescents. Pediatric infectious disease specialists also provide consultation to other health care professionals dealing with complex cases.
Education and Training
University of Michigan Medical School 2000
Board Certification
PediatricsAmerican Board of PediatricsABP- Pediatric Infectious Diseases
Provider Details
Expert Publications
- Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides.
- Synthesis of peptidyl methylcoumarin esters as substrates and active-site titrants for the prohormone processing proteases Kex2 and PC2.
- Renal transplantation after Streptococcus pneumoniae-associated hemolytic uremic syndrome.
- Reevaluating the efficacy of naturopathic ear drops.
- Precursor processing by kex2/furin proteases.
- Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin.
- Effectiveness over time of varicella vaccine.
- Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.
- Unconventional genomic architecture in the budding yeast saccharomyces cerevisiae masks the nested antisense gene NAG1.
- Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast.
- A high-throughput screening assay for small molecules that disrupt yeast cell integrity.
- The unfolded protein response is induced by the cell wall integrity
- Live Candida albicans suppresses production of reactive oxygen species in
- Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization.
- The cell wall and endoplasmic reticulum stress responses are coordinately regulated in Saccharomyces cerevisiae.
- A high-throughput assay of yeast cell lysis for drug discovery and genetic
- Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae.
- Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules.
- Age and symptoms affect the prevalence of group A beta-hemolytic streptococcus in pharyngeal cultures of school-age children.
- A novel assay of biofilm antifungal activity reveals that amphotericin B and caspofungin lyse Candida albicans cells in biofilms.
- A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis.
- Optically active 2-ethenyl-1,3-dioxolanones as 3-carbon synthons. Allylnickel
- The RAM network in pathogenic fungi.
- Antifungal drug discovery: something old and something new.
- Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes.
- A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.
- Candida albicans morphogenesis is not required for macrophage interleukin 1β production.
- Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.
- Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF
- Antifungal drug development: challenges, unmet clinical needs, and new approaches.
- Catching fire: Candida albicans, macrophages, and pyroptosis.
- Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis.
- Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.
- Unraveling the biology of a fungal meningitis pathogen using chemical genetics.
- Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs.
- Structure-activity relationships for the antifungal activity of selective estrogen receptor antagonists related to tamoxifen.
- A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.
- Voriconazole Therapeutic Drug Monitoring.
- High-Throughput Screen in Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling.
- Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase.
- Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans.
- Challenges in the development of novel anticryptococcal agents.
- The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
- The unmet clinical need of novel antifungal drugs.
- Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo.
- Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency.
- Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity.
Dr. Damian J Krysan MD's Practice location
Practice At 601 Elmwood Ave Box 635
601 Elmwood Ave -Rochester, NY 14642Get Direction
Dr. Damian J Krysan MD's reviews
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Nearest Hospitals
HIGHLAND HOSPITALl
1000 SOUTH AVENUE ROCHESTER NY 14620STRONG MEMORIAL HOSPITALl
601 ELMWOOD AVE ROCHESTER NY 14642MERCY MEDICAL CENTER - CEDAR RAPIDSl
701 10TH STREET SE CEDAR RAPIDS IA 52403