Dr. Robert J Fram M.D.
Hematologist-Oncologist | Hematology & Oncology
Immunogen, Inc. 128 Sidney St Cambridge MA, 02138About
Dr. Robert Fram is a hematologist oncologist practicing in Cambridge, MA. Dr. Fram specializes in the diagnosis, treatment and prevention of blood diseases such as anemia, hemophilia, sickle-cell disease, leukemia and lymphoma. Hematologist Oncologists are also trained in the study of cancer and its attack on other organs.
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Expert Publications
Data provided by the National Library of Medicine- Bone metastases.
- Cisplatin and platinum analogues: recent advances.
- A phase I study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenously daily for 5 consecutive days every 3 weeks in patients with advanced solid tumors.
- XMT-1001, a novel polymeric camptothecin pro-drug in clinical development for patients with advanced cancer.
- Mechanisms underlying resistance to streptozotocin in Mer+ and Mer- human tumor lines.
- Preirradiation chemotherapy of supratentorial malignant primary brain tumors with intracarotid cis-platinum (CDDP) and i.v. BCNU. A phase II trial.
- Schedule dependence of buthionine sulfoximine in reversing resistance to cisplatin.
- Pharmacokinetics and antitumor efficacy of XMT-1001, a novel, polymeric topoisomerase I inhibitor, in mice bearing HT-29 human colon carcinoma xenografts.
- DNA repair mechanisms affecting cytotoxicity by streptozotocin in E. coli.
- Mutagenesis and repair of DNA damage caused by nitrogen mustard, N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), streptozotocin, and mitomycin C in E. coli.
- Gene expression in E. coli after treatment with streptozotocin.
- Sequence specificity of streptozotocin-induced mutations.
- Gene expression caused by alkylating agents and cis-diamminedichloroplatinum(II) in Escherichia coli.
- A comparison of the effects of cytosine arabinoside and beta-lactams on DNA synthesis and cellular proliferation.
- Interactions of cis-diamminedichloroplatinum(II) with 1-beta-D-arabinofuranosylcytosine in LoVo colon carcinoma cells.
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