Dr. Tanya M. Trippett, MD

Expert Publications

• Therapeutic strategies targeting proteins that regulate folate and reduced folate transport.
• Brain metastases in hepatoblastoma.
• Non-Hodgkin's lymphoma in children and adolescents.
• [Mechanisms of resistance to methotrexate].
• Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia.
• Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study.
• Phase II study of weekly gemcitabine and vinorelbine for children with recurrent or refractory Hodgkin's disease: a children's oncology group report.
• Emerging non-transplant-based strategies in treating pediatric non-Hodgkin's lymphoma.
• Early [¹⁸F]fluorodeoxyglucose positron emission tomography-based response evaluation after treatment with gemcitabine and vinorelbine for refractory Hodgkin disease: a children's oncology group report.
• Allogeneic transplant following brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma and systemic anaplastic large cell lymphoma.
• A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors.

Clinical Trials

• Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment
• Carfilzomib in Combination With Cyclophosphamide and Etoposide for Children

Media Releases

A Beacon of Hope for Young Patients and Families Facing Challenging Cancer Diagnoses

Dr. Tanya M. Trippett, an esteemed Associate Attending Pediatrician at Memorial Sloan Kettering Cancer Center in New York, is a leading figure in the field of pediatric oncology. 

Specializing in the treatment of children with leukemia and lymphoma, Dr. Trippett focuses on cases where cancer has recurred despite prior treatments. Her expertise extends to conducting clinical research to develop and evaluate investigational therapies, particularly targeted agents that aim to inhibit the molecular pathways driving cancer growth in children.

A graduate of Duke University School of Medicine, Dr. Trippett completed her pediatrics residency at Duke University Medical Center and pursued a fellowship in pediatric hematology and oncology at Memorial Sloan Kettering Cancer Center. Board certified in both pediatrics and pediatric hematology-oncology, she is also well-versed in molecular pharmacology and translational research, with a focus on understanding drug resistance mechanisms in cancer.

Dr. Trippett is the Co-Founder of the Pediatric Oncology Experimental Therapeutics Investigator Consortium (POETIC), a collaborative initiative dedicated to developing targeted therapies for recurrent childhood cancers. Her leadership in POETIC has expanded access to innovative treatments for pediatric patients nationwide, offering new hope where conventional options have fallen short.

Recognized for her exceptional contributions, Dr. Trippett has been honored with prestigious accolades, including Castle Connolly: New York Magazine Top Doctors (2013-2018), Castle Connolly: America's Top Doctors (2023), Exceptional Women in Medicine Award, Castle Connolly (2023), Top Doctors New York Metro Area, Castle Connolly (2023), Castle Connolly: America’s Top Doctor (2024), and Castle Connolly: Exceptional Women in Medicine (2024). Her commitment to mentorship is evident in her role as a mentor to fellows who have gone on to establish their own research programs, ensuring a lasting impact in the field of pediatric oncology.

Beyond her research endeavors, Dr. Trippett is actively involved in addressing global disparities in pediatric cancer care, leading efforts to establish a state-of-the-art international children’s cancer center in Ghana, the first in Sub Saharan Africa, through her charitable organization. Her advocacy for accessible healthcare underscores her dedication to providing life-saving treatments to children in underserved regions, showcasing her belief in the transformative power of accessible healthcare access.

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