Sheila I Negron
Social Worker
150 MEADOW ST NAUGATUCK CT, 06770About
Sheila I Negron is a top Social Worker in NAUGATUCK, CT. With a passion for the field and an unwavering commitment to their specialty, Sheila I Negron is an expert in changing the lives of their patients for the better. Through their designated cause and expertise in the field, Sheila I Negron is a prime example of a true leader in health care. As a leader and expert in their field, Sheila I Negron is passionate about enhancing patient quality of life. They embody the values of communication, safety, and trust when dealing directly with patients. In NAUGATUCK, CT, Sheila I Negron is a true asset to their field and dedicated to the profession of medicine.
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Expert Publications
Data provided by the National Library of Medicine- Effect of p53 status on sensitivity to platinum complexes in a human ovarian cancer cell line.
- DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
- The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
- Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
- Characterisation of molecular events following cisplatin treatment of two curable ovarian cancer models: contrasting role for p53 induction and apoptosis in vivo.
- The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
- The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
- Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.
- Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
- DT-diaphorase: questionable role in mitomycin C resistance, but a target for novel bioreductive drugs?
- Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins.
- Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice.
- Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice.
- Effects of elevated temperature on misonidazole O-demethylation by mouse liver microsomes: kinetic and stability studies of a model mixed-function oxidase reaction.
- A microcomputer controlled, local hyperthermia system for uniform tumour heating in unanaesthetized mice.
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