Dr. Ian J. Reynolds, MD, FAAOS

Expert Publications

• High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations.
• Glutamate-induced neuron death requires mitochondrial calcium uptake.
• Characterization of the effects of polyamines on [125I]MK-801 binding to recombinant N-methyl-D-aspartate receptors.
• The use of ligand binding in assays of NMDA receptor function.
• Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists.
• Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated [Ca(2+)](i) increases and NMDA receptor mRNA levels.
• Mitochondrial membrane potential and the permeability transition in excitotoxicity.
• Subcellular localization of glutamate-stimulated intracellular magnesium concentration changes in cultured rat forebrain neurons using confocal microscopy.
• Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons.
• Astrocytes are more resistant than neurons to the cytotoxic effects of increased [Zn(2+)](i).
• Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release.
• Pharmacological investigation of mitochondrial ca(2+) transport in central neurons: studies with CGP-37157, an inhibitor of the mitochondrial Na(+)-Ca(2+) exchanger.
• MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants.
• Quantitative evaluation of mitochondrial calcium content in rat cortical neurones following a glutamate stimulus.
• Spontaneous changes in mitochondrial membrane potential in cultured neurons.

Media Releases

Get to know Orthopedic Surgeon Dr. Ian J. Reynolds, who serves the population of Webster, Texas. Dr. Ian J. Reynolds is an established Orthopedic Surgeon currently serving patients within his own private practice in Webster, Texas. He is also affiliated with the Surgery Specialty Hospitals of America, and has privileges at Bay Area Regional Medical Center and The Hospital for Specialized Surgery in Houston. Dr. Reynolds features nearly four decades of experience in his field, and has a special expertise in sports medicine, arthroscopic surgery, joint replacement, spine surgery, ligament surgery, and surgery of the hand and foot. Dr. Reynolds attended Indiana University School of Medicine in Indianapolis, graduating with his Medical Degree in 1971. Following the completion of medical school, he completed an internship at Methodist Hospital, prior to his residency training at the Ochsner Foundation Hospital of New Orleans. Dr. Reynolds is certified by the American Board of Orthopaedic Surgery, and has earned the coveted title of Fellow of the American Academy of Orthopaedic Surgeons. To keep up to date with the latest advances in his field, Dr. Reynolds maintains a professional membership with the Texas Orthopaedic Association, the Southern Orthopaedic Association, the Texas Society of Sports Medicine, the Southern Medical Association, and the Texas Medical Association. He attributes his success to his motivation to help patients regain their health and mobility, and in his free time, Dr. Reynolds enjoys traveling and skiing, and he is also an amateur scientist with a special interest in water purification systems. Dr. Reynolds also has skin care anti-aging products distributed under the name JPaul Skin Care. He is a patent holder for a method of manufacturing timed released amino acids and glutamine, creatine and whey supplements, and is also interested in aviation and current has two designs for a commuter jet and a supersonic business jet that are in development. Orthopaedic surgeons are devoted to the prevention, diagnosis, and treatment of disorders of the bones, joints, ligaments, tendons and muscles. Some orthopaedists are generalists, while others specialize in certain areas of the body, others specialty focuses include shoulder and elbow, hand, and spine. Orthopaedic surgeons treat broken bones, and replace painful joints, and also treat patients for sports injuries, back pain, ruptured discs and spinal stenosis, bone tumors, carpal tunnel, hand arthritis and hand injuries, club foot, bow legs and hip dysplasia, orthopaedic trauma, limb lengthening, achilles tendon injuries, bunions and foot and ankle injuries, osteoporosis, and arthritis.

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