Dr. Mark R. Nicolls MD

Awards

•  2014 Elected Member, The American Society for Clinical Investigation 

Treatments

• Lung Transplant, Heart Transplant, Pulmonary Hypertension

Fellowships

• University of Colorado School of Medicine CO    1999

Publications

• Immunologic researchLeukotrienes in pulmory arterial hypertension.2014
• AMERICAN JOURL OF THE MEDICAL SCIENCESEfficacy of Transthoracic Echocardiography for Diagnosing Heart Failure in Septic Shock2014
• DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASEApplication of a non-amplification-based technology to detect invasive fungal pathogens2014
• The Jourl of clinical investigationWorking toward immune tolerance in lung transplantation.2014
• American jourl of respiratory cell and molecular biologyNF-?B inhibition reduces lung vascular lumen obliteration in severe pulmory hypertension in rats.0
• Circulation researchInflammation and immunity in the pathogenesis of pulmory arterial hypertension.2014
• Jourl of molecular medicine (Berlin, Germany)Graft microvascular disease in solid organ transplantation.0
• Vascular cellMacrophages in solid organ transplantation.2014
• BiomaterialsPromotion of airway astomotic microvascular regeneration2014
• Arteriosclerosis, thrombosis, and vascular biologyThe critical role of mR destabilizing protein heterogeneous nuclear ribonucleoprotein d2014
• Respiratory medicineComplement components as potential therapeutic targets for asthma treatment.0
• CellTemporal response of the human virome to immunosuppression and antiviral therapy.2013
• PLOS ONEAspergillus fumigatus Invasion Increases with Progressive Airway Ischemia2013
• SCIENCE TRANSLATIOL MEDICINEBlocking Macrophage Leukotriene B-4 Prevents Endothelial Injury and Reverses Pulmory Hypertension2013
• Transplantation proceedingsEpithelial to mesenchymal transition in murine tracheal allotransplantation2013
• Proceedings of the tiol Academy of Sciences of the United States of AmTargeting complement component 5a promotes vascular integrity and limits airway remodeling.2013
• ARTHRITIS AND RHEUMATISMEditorial: Developing Better Biomarkers for Connective Tissue DiseaseAssociated Interstitial Lung2013
• Advances in experimental medicine and biologyComplement-mediated microvascular injury leads to chronic rejection.2013
• Jourl of molecular medicine (Berlin, Germany)Tie2-dependent VHL knockdown promotes airway microvascular regeneration0
• EUROPEAN RESPIRATORY JOURLPathobiology of pulmory arterial hypertension and right ventricular failure2012
• AMERICAN JOURL OF RESPIRATORY CELL AND MOLECULAR BIOLOGYSevere Pulmory Arterial Hypertension Induced by SU5416 and Ovalbumin Immunization2012
• AMERICAN JOURL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGYNew methods for monitoring dymic airway tissue oxygetion and perfusion2012
• Pulmory circulationNew models of pulmory hypertension based on VEGF receptor blockade2012
• American jourl of physiology. Lung cellular and molecular physiologyNeotal mice genetically modified to express the elastase inhibitor elafin are protected2012
• AMERICAN JOURL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGYNeotal mice genetically modified to express the elastase inhibitor elafin are protected2012
• AMERICAN JOURL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGYA brief overview of mouse models of pulmory arterial hypertension: problems and prospects2012
• Critical care (London, England)Potential for overuse of corticosteroids and vasopressin in septic shock.2012
• CIRCULATION RESEARCHCD4(+) T Cells and Complement Independently Mediate Graft Ischemia in the Rejection of Mouse2011
• CIRCULATION RESEARCHRegulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmory Hypertension2011
• AMERICAN JOURL OF RESPIRATORY AND CRITICAL CARE MEDICINEInhibiting Lung Elastase Activity Ebles Lung Growth in Mechanically Ventilated Newborn Mice2011
• TRENDS IN CARDIOVASCULAR MEDICINERegulatory T Cells and Pulmory Hypertension2011
• JOURL OF CLINICAL INVESTIGATIONAdenovirus-mediated HIF2011
• CHESTSurvival in Pulmory Hypertension Registries The Importance of Incident Cases Response2011
• RESPIRATORY RESEARCHImmunomodulatory strategies prevent the development of autoimmune emphysema2010
• AMERICAN JOURL OF RESPIRATORY AND CRITICAL CARE MEDICINEStrategic Plan for Lung Vascular Research An NHLBI-ORDR Workshop Report2010
• CHESTCharacterization of Connective Tissue Disease2010
• CURRENT OPINION IN ORGAN TRANSPLANTATIONBronchial blood supply after lung transplantation without bronchial artery revascularization2010
• AMERICAN JOURL OF RESPIRATORY AND CRITICAL CARE MEDICINELung Transplant Airway Hypoxia A Diathesis to Fibrosis?2010
• Tamosiuniene, R., Long, C., Ambler, K., Sung, Y., Gera, L., Wang, L., Immune Reconstitution Prevents Autoimmune Inflammation2009
• Tamosiuniene, R., Long, C., Ambler, K., Wang, L., Gera, L., Sung, Y., Prevention of Adverse Right Ventricular Remodeling2009
• RESPIRATIONIncreased regulatory2008
• JOURL OF CLINICAL INVESTIGATIONMicrovascular destruction identifies murine allografts that cannot be rescued from airway fibrosis2007
• IMMUNOLOGY LETTERSEndogenous sigls released from necrotic cells augment inflammatory responses to bacterial endotoxin2007
• ANTIOXIDANTS & REDOX SIGLINGOxidant stress, immune dysregulation, and vascular function in type I diabetes2007
• ANTIOXIDANTS & REDOX SIGLINGHypoxia and the lung: Beyond hypoxic vasoconstriction2007
• TRANSPLANTATIONTransfer of allograft specific tolerance requires CD4(+)CD25(+)T cells but not interleukin2007
• BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTSThymoquinone attenuates proinflammatory responses in lipopolysaccharide2007
• TRANSPLANTATIONThe matrix comes to lung transplantation2007
• CHESTAngiogenesis in chronic lung disease2007
• Am J Respir Crit Care MedAbsence of T cells confers increased pulmory arterial hypertension and vascular remodeling.2007
• Proceedings of the American Thoracic SocietyIs alveolar destruction and emphysema in chronic obstructive pulmory disease an immune disease?2006
• Proceedings of the American Thoracic SocietyMechanisms of autoimmune emphysema.2006
• IMMUNOLOGY LETTERSEffect of thymoquinone on cyclooxygese expression and prostaglandin production2006
• BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTSDownregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation2006
• INTERTIOL IMMUNOPHARMACOLOGYAnti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation2006
• AMERICAN JOURL OF TRANSPLANTATIONLFA-1 (CD11a) as a therapeutic target2006
• EUROPEAN RESPIRATORY JOURLAutoimmunity and pulmory hypertension: a perspective2005
• CHESTThe protective role of T-lymphocytes in pulmory vascular remodeling2005
• JOP : Jourl of the pancreasType 2 diabetes mellitus as a conformatiol disease.2005
• JOURL OF CLINICAL INVESTIGATIONChemokine-mediated angiogenesis: an essential link in the evolution of airway fibroses?2005
• JOURL OF IMMUNOLOGYSimultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway2005
• AMERICAN JOURL OF RESPIRATORY AND CRITICAL CARE MEDICINEAn animal model of autoimmune emphysema2005
• AMERICAN JOURL OF TRANSPLANTATIONFollowing universal prophylaxis with intravenous ganciclovir and cytomegalovirus immune globulin2004
• CURRENT ALZHEIMER RESEARCHThe Clinical and Biological Relationship between Type II Diabetes Mellitus and Alzheimer's Disease2004
• JOURL OF PROTEOME RESEARCHGene microarray study corroborates proteomic findings in rodent islet cells2003
• JOURL OF PROTEOME RESEARCHProteomics as a tool for discovery2003
• JOURL OF IMMUNOLOGYCD4-dependent generation of domint transplantation tolerance induced by simultaneous perturbation2002
• TRANSPLANTATIONInterferon-gamma is not a universal requirement for islet allograft survival2002
• INTERTIOL IMMUNOLOGYReversal of experimental allergic encephalomyelitis with non-mitogenic2001
• Nicolls, M. R., Coulombe, M., Gill, R. G.The basis of immunogenicity of endocrine allografts2001
• JOURL OF IMMUNOLOGYAnti-LFA-1 therapy induces long-term islet allograft acceptance in the absence of IFN-gamma or IL-42000
• AMERICAN JOURL OF RESPIRATORY AND CRITICAL CARE MEDICINEDiffuse alveolar hemorrhage with underlying pulmory capillaritis in the retinoic acid syndrome1998
• TRANSPLANTATIONINDUCTION OF TOLERANCE TO HEART ALLOGRAFTS IN RATS USING POSTTRANSPLANT TOTAL LYMPHOID IRRADIATION1993
• TRANSPLANTATIONINDUCTION OF LONG-TERM SPECIFIC TOLERANCE TO ALLOGRAFTS IN RATS BY THERAPY WITH AN ANTI1993

Experience & Accolades

• Program Director 2009 - 2010Pulmonary and Critical Care Fellowship
• Member2010 - 2014 Chief, Pulmonary and Critical Care Medicine
• Member2007 - 2014 Faculty, Vera Moulton Wall Center For Pulmonary Vascular Disease
• Member 2007 - 2014 Stanford Cardiovascular Institute
• Director 2007 - 2014 Lung Immunology
• Member2007 - 2014 Joint Appointment, Immunology & Rheumatology
• Member2007 - 2014 Institute for Immunity, Transplantation and Infection

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