Ozlem Kulak, MD, PhD, Pathologist | Anatomic Pathology & Clinical Pathology
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Ozlem Kulak, MD, PhD

Pathologist | Anatomic Pathology & Clinical Pathology

130 S 9th St Philadelphia PA, 19107


Dr. Ozlem Kulak is a pathologist specilized in gastrointestinal system and liver practicing in Philadelphia, PA. Dr. Kulak is a doctor who specializes in the study of tissues and bodily fluids. As a pathologist, Dr. Kulak can help your primary care doctor make a diagnosis about your medical condition. Dr. Kulak may perform a tissue biopsy to determine if a patient has cancer, practice genetic testing, and complete a number of laboratory examinations. Pathologists can also perform autopsies which can determine a persons cause of death and gain information about genetic progression of a disease.

Education and Training

Ankara University MD 1981

UT Southwestern Medical Center PhD 2015

Johns Hopkins Hospital Gastrointestinal/Liver Fellow 2022

Board Certification

American Board of Pathology

Provider Details

Male German, Turkish

Areas of expertise and specialization

Gastrointestinal/Liver Pathology

Faculty Titles & Positions

  • Assistant Professor Thomas Jefferson University Hospital 2022 - Present


  • John H. Yardley Fellow in Gastrointestinal Pathology 2021 John Hopkins Hospital 
  • Children’s Medical Center Laboratory, 14tth Annual Transfusion & Laboratory Medicine Conference Award, Scientific Abstract Competition 2021 Children’s Medical Center Laboratory 


  • Johns Hopkins Hospital, Gastrointestinal/Liver Fellow, Department of Pathology

Articles and Publications

  • 1.Kulak O, Osipov A, Hendifar AE, Nissen NN, Cox BK, Hruban RH, Hutchings DA. Pancreatoblastoma in Elderly Adults: Report of Two Patients. Int J Surg Pathol. 2022 Oct 30:10668969221133347. doi: 10.1177/10668969221133347. Epub ahead of print. PMID: 36314453.2.Kulak O, Gurram B, Montgomery EA, Park JY. Pediatric autoimmune gastritis: Clinical correlates and histologic features. Hum Pathol. 2021 Jul 17:S0046-8177(21)00123-4. doi: 10.1016/j.humpath.2021.07.002. PMID: 34284050.3.Kulak O, Drobysheva A, Wick N, Arvisais-Anhalt S, Germans SK, Timmons CF, Park JY. Smart Glasses as a Surgical Pathology Grossing Tool. Arch Pathol Lab Med. 2021 Apr 1;145(4):457-460. doi: 10.5858/arpa.2020-0090-OA. PMID: 32823276.4.Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L. Disruption of Wnt/-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Mol Cell Biol. 2015 Jul; 35(14): 2425-35. doi: 10.1128/MCB.00392-155.Kulak O, Yamaguchi K, Lum L. Identification of therapeutic small molecule leads in cultured cells using multiplexed pathway reporter read-outs. Methods Mol Biol. 2015; 1263:3-14. doi: 10.1007/978-1-4939-2269-7_1.6.Kulak O, Lum, L. A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells. J. Vis. Exp. (77), e50369, doi: 10.3791/50369 (2013).7.Koirala S, Klein J, Zheng Y, Glenn NO, Eisemann T, Fon Tacer K, Miller DJ, Kulak O, Lu M, Finkelstein DB, Neale G, Tillman H, Vogel P, Strand DW, Lum L, Brautigam CA, Pascal JM, Clements WK, Potts PR. Tissue-Specific Regulation of the Wnt/-Catenin Pathway by PAGE4 Inhibition of Tankyrase. Cell Rep. 2020;32(3):107922. doi: 10.1016/j.celrep.2020.1079228.Germans SK, Kulak O, Koduru P, Oliver D, Gagan J, Patel P, Anderson LD, Fuda FS, Chen W, Jaso JM (2020) Lenalidomide-Associated Secondary B-lymphoblastic Leukemia/Lymphoma- A Unique Entity: A Report of Two Cases with Low-Level Bone Marrow Involvement and Review of the Literature, American Journal of Clinical Pathology, Manuscript ID: AJCP-2020-03-0153.R19.Torres MJ, Pandita RK, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt CR, Zhao Y, Lum L, Zaman A, Yeaman C, White MA, Pandita TK. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015 Nov; 35(21): 3633-45. doi: 10.1128/MCB.00768-15. Epub 2015 Aug 17.10.Fan C, Yarravarapu N, Chen H, Kulak O, Dasari P, Herbert J, Yamaguchi K, Lum L, Zhang X. Regulation of tankyrase activity by a catalytic domain dimer interface. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1780-1785. doi: 10.1016/j.bbrc.2018.07.113. Epub 2018 Jul 26.11.Lum L, Chen C, Zhang X, Kulak O, Wu X Indolinyl-Sulfonamide Inhibitors of Tankyrase, patent application Filed May 2, 2015(62/156,260)12.Lum L and Kulak O. A Multiplexed Luciferase-Based Reporter Assay System Using Small Molecule Inhibitors of Firefly and Renilla Luciferase Enzymes. Filed Oct. 20, 2010. Published April 26, 2012. Issued Oct. 29, 2013 (12/908,754). 13.Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L. (2011). Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling. Science Signaling. 25 January 2011Vol. 4, Issue 157, p. ra414.Baloglu E, Kiziltepe O, Gurdal H. (2007) The role of Gi proteins in reduced vasorelaxation response to -adrenoreceptor agonists in rat aorta during maturation. European journal of pharmacology. 564(1-3), 167-73.

Areas of research

  • Autoimmune gastritis, Wnt pathway

Ozlem Kulak, MD, PhD's Practice location

130 S 9th St -
Philadelphia, PA 19107
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