Dr. Sean Whelan is a general surgeon practicing in Pittsburgh, PA. Dr. Whelan specializes in abdominal contents including the esophagus, stomach, liver, gallbladder, pancreas and often thyroid glands. General surgeons are able to deal with almost any surgical or critical care emergency, also involving the skin or soft tissue trauma. Dr. Whelan provides quality surgical service for gravely ill or injured patients and is able to respond quickly due to knowledge of various surgical procedures.
- Identification of a minimal size requirement for termination of vesicular stomatitis virus mRNA: implications for the mechanism of transcription.
- Transcription and replication initiate at separate sites on the vesicular stomatitis virus genome.
- Transcriptional control of the RNA-dependent RNA polymerase of vesicular stomatitis virus.
- Transcription and replication of nonsegmented negative-strand RNA viruses.
- Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection.
- Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity.
- An antiviral role for the RNA interference machinery in Caenorhabditis elegans.
- Viral transgenesis of embryonic cell cultures from the freshwater microcrustacean Daphnia.
- A unique strategy for mRNA cap methylation used by vesicular stomatitis virus.
- Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation.
- Vesicular stomatitis virus mRNA capping machinery requires specific cis-acting signals in the RNA.
- Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.
- A conserved motif in region v of the large polymerase proteins of nonsegmented negative-sense RNA viruses that is essential for mRNA capping.
- Response to "Non-segmented negative-strand RNA virus RNA synthesis in vivo".
- Opposing effects of inhibiting cap addition and cap methylation on polyadenylation during vesicular stomatitis virus mRNA synthesis.
- Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization.
- Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein.
- A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry.
- A broad-spectrum antiviral targeting entry of enveloped viruses.
- Peroxisomes are signaling platforms for antiviral innate immunity.
- Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus.
- Protein expression redirects vesicular stomatitis virus RNA synthesis to cytoplasmic inclusions.
- Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.
- The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis.
- Assembly of a functional Machupo virus polymerase complex.
- Molecular architecture of the vesicular stomatitis virus RNA polymerase.
- A freeze frame view of vesicular stomatitis virus transcription defines a minimal length of RNA for 5' processing.
- A recombinant vesicular stomatitis virus bearing a lethal mutation in the glycoprotein gene uncovers a second site suppressor that restores fusion.
- Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors.
- Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.
- The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway.
- Genetic inactivation of COPI coatomer separately inhibits vesicular stomatitis virus entry and gene expression.
- Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex.
- Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase.
- Ebola virus entry requires the host-programmed recognition of an intracellular receptor.
- Structural properties of the C terminus of vesicular stomatitis virus N protein dictate N-RNA complex assembly, encapsidation, and RNA synthesis.
- Architecture and regulation of negative-strand viral enzymatic machinery.
- Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus.
- A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs.
- Methods to study RNA virus molecular biology.
- Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.
- Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates.
- The polymerase of negative-stranded RNA viruses.
- Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.
- mRNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo.
- Sensitivity of the polymerase of vesicular stomatitis virus to 2' substitutions
- A genome-wide small interfering RNA screen identifies host factors required for vesicular stomatitis virus infection.
- Recoding of the vesicular stomatitis virus L gene by computer-aided design provides a live, attenuated vaccine candidate.
- Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era--a Conference at Harvard Medical School.
- Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.
- Tracking the Fate of Genetically Distinct Vesicular Stomatitis Virus Matrix Proteins Highlights the Role for Late Domains in Assembly.
- Infectious Entry Pathway Mediated by the Human Endogenous Retrovirus K Envelope Protein.
- Identification and Characterization of a Novel Broad-Spectrum Virus Entry
- Repeatable Population Dynamics among Vesicular Stomatitis Virus Lineages Evolved under High Co-infection.
- A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry.
- Correction for Soh and Whelan, Tracking the Fate of Genetically Distinct Vesicular Stomatitis Virus Matrix Proteins Highlights the Role for Late Domains in Assembly.
- Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector.
- Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body.
- Phenotypic lentivirus screens to identify functional single domain antibodies.
- An In Vitro RNA Synthesis Assay for Rabies Virus Defines Ribonucleoprotein Interactions Critical for Polymerase Activity.
- Mechanism of membrane fusion induced by vesicular stomatitis virus G protein.
- NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.
- Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones.
- Role of the intergenic dinucleotide in vesicular stomatitis virus RNA transcription.
- cis-Acting signals involved in termination of vesicular stomatitis virus mRNA synthesis include the conserved AUAC and the U7 signal for polyadenylation.
- Regulation of RNA synthesis by the genomic termini of vesicular stomatitis virus: identification of distinct sequences essential for transcription but not replication.
- The 5' terminal trailer region of vesicular stomatitis virus contains a position-dependent cis-acting signal for assembly of RNA into infectious particles.
Dr. Sean Patrick Whelan M.D.'s Practice location
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SAINT MARYS, PA 15857Get Direction
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