Dr. Douglas Heuman is a hepatologist practicing in Richmond, VA. Dr. Heuman specializes in the study of body parts such as the liver, the biliary tree, the gallbladder and the pancreas. Hepatologists manage disorders in these areas and are specifically known for treating viral hepatitis. Patients who have received liver transplants also follow up with hepatologists after their procedure.
Education and Training
Univ Of Ma Med Sch- Worcester Ma 1977
University of Massachusetts / Worcester Campus 1977
University Of Massachusetts Medical School 1977
Internal MedicineAmerican Board of Internal MedicineABIM
- Cholesterol enhances membrane-damaging properties of model bile by increasing the intervesicular-intermixed micellar concentration of hydrophobic bile salts.
- Long-term management of cirrhosis. Appropriate supportive care is both critical and difficult.
- Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis.
- Small intestinal neoplasms.
- The source of the bile: the legacy of Mathias Möckel.
- Development and application of a polymerase chain reaction assay for the detection and enumeration of bile acid 7alpha-dehydroxylating bacteria in human feces.
- Cutae morphea associated with chronic hepatitis C.
- Utility of the MELD score for assessing 3-month survival in patients with liver cirrhosis: one more positive answer.
- Function and regulation of hydroxylases involved in the bile acid biosynthesis pathways.
- Mikulicz syndrome associated with a malignant large cell gastric lymphoma: a case report and review of the literature.
- Fructose diphosphate attenuates the acetaminophen-induced liver injury in the rat evidence for involvement of nitric oxide.
- High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics.
- Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate.
- Comparison of the effects of intravenously and orally administered esomeprazole on acid output in patients with symptoms of gastro-oesophageal reflux disease.
- Safety of an immune-enhancing nutrition supplement in cirrhotic patients with history of encephalopathy.
- Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis.
- Effects of perturbations in hepatic free and esterified cholesterol pools on bile acid synthesis, cholesterol 7 alpha-hydroxylase, HMG-CoA reductase, acyl-CoA:cholesterol acyltransferase and cytosolic cholesteryl ester hydrolase.
- Regulation of bile acid synthesis.
- Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites.
- Physiological responses to increased dietary cholesterol: the case of the egg
- Hyponatremia in cirrhosis answers and questions.
- Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat.
- Predictors of the recurrence of hepatic encephalopathy in lactulose-treated patients.
- Effect of hydrophobic bile acids on 3-hydroxy-3-methylglutaryl-coenzyme A
- Receptor-mediated stimulation of taurocholate efflux from the rat hepatocyte and the ex vivo perfused rat liver.
- Disruption of sleep architecture in minimal hepatic encephalopathy and ghrelin secretion.
- Linkage of gut microbiome with cognition in hepatic encephalopathy.
- Muscle and mortality in cirrhosis.
- Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis.
- Effect of hepatic impairment on the pharmacokinetics of pasireotide (SOM230): results from a multicenter phase I study.
- A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy.
- Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation.
- Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis.
- Proton pump inhibitors are associated with a high rate of serious infections in
- Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.
- Cholesterol and bile acid metabolism in cultures of primary rat bile ductular epithelial cells.
- Bile salts in submicellar concentrations promote bidirectional cholesterol transfer (exchange) as a function of their hydrophobicity.
- Non-selective beta-blockers are not associated with serious infections in veterans with cirrhosis.
- Altered profile of human gut microbiome is associated with cirrhosis and its complications.
- Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function.
- Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy.
- Simultaneous measurement of cholesterol 7 alpha-hydroxylase activity by reverse-phase high-performance liquid chromatography using both endogenous and exogenous [4-14C]cholesterol as substrate.
- Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus.
- Erratum: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus.
- Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Cabozantinib.
- HCV eradication does not impact gut dysbiosis or systemic inflammation in cirrhotic patients.
- Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions.
- Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat.
- Brain Training with Video Games in Covert Hepatic Encephalopathy.
- Fungal dysbiosis in cirrhosis.
- Mindfulness-Based Stress Reduction Therapy Improves Patient and Caregiver-Reported Outcomes in Cirrhosis.
- Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut-Liver Axis.
- Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat.
- Medical therapy of gallstones: state of the art.
- Effects of ursodeoxycholic acid, analogues of ursodeoxycholic acid and combination of bile acids on bile acid synthesis in cultured rat hepatocytes.
- Endoscopic treatment of biliary tract disease.
- Endoscopic laser therapy for GI diseases.
- Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7 alpha-hydroxylase in rats with biliary fistulas.
- Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in rats with subtotal nephrectomy.
- Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7 alpha-hydroxylase.
- Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts.
- Studies of alteration of hepatic cholesterol metabolism in puromycin-induced nephrotic syndrome in rats.
- Lack of efficacy of ketorolac tromethamine for analgesia on patients undergoing colonoscopy.
- Cholesterol 7 alpha-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat.
- Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat.
- Hepatoprotective properties of ursodeoxycholic acid.
- Bile salt-membrane interactions and the physico-chemical mechanisms of bile salt toxicity.
- Hep G2 cells: a model for studies on regulation of human cholesterol 7alpha-hydroxylase at the molecular level.
- Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection.
- Distribution of mixtures of bile salt taurine conjugates between lecithin-cholesterol vesicles and aqueous media: an empirical model.
- Metabolic fate and hepatocyte toxicity of reverse amide analogs of conjugated ursodeoxycholate in the rat.
- Lecithin protects against plasma membrane disruption by bile salts.
- Type 2 Diabetes
- Colon Polyps
- Hepatitis C
- Oh State Univ Hosp, Gastroenterology; Med Coll Of Virginia Hosp, Internal Medicine
- Virginia Commonwealth University Health System Program
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