Dr. Christine Seroogy practices Pediatric Rheumatology in Madison, WI. Pediatric rheumatologists treat child patients who suffer from pain in the musculoskeletal system, have symptoms of arthritis, or an autoimmune disorder. Dr. Seroogy evaluates and treats a variety of joint, muscle, and bone disorders; including autoimmune disorders, such as lupus, juvenile rheumatoid arthritis, scleroderma, Kawasaki disease, post-infectious arthritis, chronic vasculitis, and inflammatory disorders of the muscle, eye, or other organs. Dr. Seroogy also is trained in the evaluation of prolonged fever, unexplained complaints of chronic musculoskeletal pain, weakness, poor appetite, fatigue, and/or loss of function or skills.
Education and Training
University of Mn Med Sch 1993
- The application of gene therapy in autoimmune diseases.
- Gene therapy for autoimmune disease.
- Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis.
- Application of gene therapy in autoimmune disease.
- Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4.
- T-cell anergy: from phenotype to genotype and back.
- Dendritic cells amplify T cell-mediated immune responses in the central nervous system.
- GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype.
- Preservation of self: an overview of E3 ubiquitin ligases and T cell tolerance.
- Daily subcutaneous injections of peptide induce CD4+ CD25+ T regulatory cells.
- Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy.
- Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures.
- Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin.
- Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions.
- Sustained expression of GRAIL during hematopoiesis results in dysregulated differentiation.
- 2011, 2011 Best Doctors in America
- 2012 UW Health Patient Experience Physician Champion Award
- Children's Hospital Boston
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