Dr. Wei Tian, MD

Areas of expertise and specialization

Faculty Titles & Positions

• VP, Medical Director, Urologic Pathology Inform Diagnostics 2018 - Present

Awards

• The NASHNP Award for Best Platform Presentation 2010 USCAP, Washington, DC 
• Outstanding Resident Award 2011 Department of Pathology, Oregon Health & Science University 

Professional Memberships

• United States & Canadian Academy of Pathology (USCAP)  
• American Urological Association (AUA)  
• Genitourinary Pathology Society (GUPS)  
• International Society of Urological Pathology (ISUP)  
• Texas Pathology Association  

Professional Society Memberships

• United States & Canadian Academy of Pathology, College of American Pathologists, American Urological Association, Genitourinary Pathology Society, International Society of Urological Pathology

Areas of research

ERG and PTEN expression in prostate cancer, intraducatl carcinoma and atypical intraductal proliferation of the prostate, urinary cytology diagnosis.  

Selective Publications

1.      Tian W, Shore KT, Shah RB. Significant Reduction of Indeterminate (Atypical) Diagnosis after Implementation of The Paris System for Reporting Urinary Cytology: A Single Institutional Study of More Than 27,000 Cases. Cancer Cytopathol. 2021 Feb;129(2):114-120.

2.      Shah RB, Shore KT, Tian W. PTEN loss in prostatic adenocarcinoma correlates with specific adverse histologic features (intraductal carcinoma, cribriform Gleason pattern 4 and stromogenic carcinoma. Prostate. 2019 Aug; 79(11):1267-1273.

3.      Tian W, Dorn D, Wei S, Sanders RD, Matoso A, Shah RB, Gordetsky J. GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall. Histopathology. 2017 Jul;71(1):150-155.

4.   Shah RB, Yoon J, Liu G, Tian W. Atypical Intraductal Proliferation and Intraductal Carcinoma of the Prostate on Core Needle Biopsy: A Comparative Clinicopathological and Molecular Study with a Proposal to Expand Morphological Spectrum of Intraductal Carcinoma. Histopathology. 2017  Nov;71(5):693-702.

5.     Shah RB, Leandro G, Romerocases G, Bentley J, Yoon J, Mendrinos S, Tadros Y, Tian W, Lash R. Improvement in inter-observer reproducibility in resolving an “Atypical glands suspicious for prostate cancer” diagnosis in prostate biopsies using a novel “Diseased focused diagnostic review” quality process. Human Pathol, 2016 56: 155-62. (Featured as Top 10 (#3) Best articles of 2016 by Pathology Editor’s Choice by MDLinx Pathology). 

6.      Tian W, Epstein JI. Invasive low-grade papillary urothelial carcinoma: an immunohistochemical study of 26 cases. Hum Pathol. 2015 Dec; 46(12):1836-41.

7.      Tian W, Epstein JI, Netto G, etc. Utility of Uroplakin II expression as a Marker of Urothelial Carcinoma. Human Pathology. 2015 Jan;46(1):58-64.

8.       Zhong M, Tian W, Zhuge J, Zheng X, Huang T, Cai D, Zhang D, Yang XJ, Argani P, Fallon JT, Epstein JI. Distinguishing Nested Variants of Urothelial Carcinoma From Benign Mimickers by TERT Promoter Mutation. Am J Surg Pathol. 2015 Jan;39(1):127-31.

9.      Tian W, Latour M, Epstein JI. Endometrial Stromal Sarcoma Involving The Urinary Bladder: A Study of 6 Cases. AM J Surg Pathol 2014 Jul;38(7):982-9.

10.   Cao WB, Tian W, Hong J, Li D, Tavares R, Noble L, Moss SF, Resnick MB. Expression of bile acid receptor TGR5 in gastric adenocarcinoma.  Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G322-7.

11.   Tian W, Yakirevich E, Matoso A and Gnepp D. IgG4 positive plasma cells in sclerosing variant of mucoepidermoid  carcinoma: a new and evolving concept. Am J of Surg Pathol 2012 Jul; 36(7): 973-9.

12.    Tian W, Fu Y, Garcia-Elias A , Fernandez-Fernandez J, Kramer P, Klein R ,  Hitzemann R, Orwoll E, Wilmot B, McWeeney S, Valverde M, Cohen DM. A loss-of-function non-synonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):14034-9.

13.   Fu Y, Tian W, Pratt EB, Dirling L, Shyng SL, Meshul CK, Cohen DM. Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PLoS One. 2009 May 25; 4(5): e5679.

14.    Tian W, Fu Y, Wang DH, Cohen DM. Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant. Am J Physiol Renal Physiol. 2006 Jan; 290(1):F117-26.

15.     Xu H, Tian W, Lindsley JN, Oyama TT, Capasso JM, Rivard CJ, Cohen HT, Bagnasco SM, Anderson S, Cohen DM. EphA2: expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo. Am J Physiol Renal Physiol. 2005 Apr; 288(4):F855-66.

16.      Tian W, Salanova M, Xu H, Lindsley JN, Oyama TT, Anderson S, Bachmann S, Cohen DM. Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments. Am J Physiol Renal Physiol. 2004 Jul; 287(1): F17-24.

17.     Tian W, Cohen DM. Urea stress is more akin to EGF exposure than to hypertonic stress in renal medullary cells. Am J Physiol Renal Physiol. 2002 Sep; 283(3):F388-98.

18.    Zhao H, Tian W, Cohen DM. Rottlerin inhibits tonicity-dependent expression and action of TonEBP in a PKCdelta-independent fashion. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F710-7.

19.     Tian W, Bonkovsky HL, Shibahara S, Cohen DM. Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells. Am J Physiol Renal Physiol. 2001 Nov; 281 (5):F983-91.

20.     Tian W, Cohen DM. Signaling and gene regulation by urea in cells of the mammalian kidney medulla. Comp Biochem Physiol A Mol Integr Physiol. 2001 Oct; 130(3):429-36. Review.

21.     Tian W, Cohen DM. Urea inhibits hypertonicity-inducible TonEBP expression and action. Am J Physiol Renal Physiol. 2001 May; 280(5):F904-12.

22.     Tian W, Zhang Z, Cohen DM. MAPK signaling and the kidney. Am J Physiol Renal Physiol. 2000 Oct; 279(4):F593-604. Review.

23.     Zhang Z, Tian W, Cohen DM. Urea protects from the proapoptotic effect of NaCl in renal medullary cells. Am J Physiol Renal Physiol. 2000 Aug; 279(2):F345-52.

24.    Tian W, Boss GR, Cohen DM. Ras signaling in the inner medullary cell response to urea and NaCl. Am J Physiol Cell Physiol. 2000 Feb; 278(2):C372-80.

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