Dr. James Alexander Fagin M.D.
Endocrinology-Diabetes | Endocrinology, Diabetes & Metabolism
1275 York Ave New York NY, 10021Rating
4/5
About
I am a board-certified endocrinologist and internist, and I treat patients with thyroid cancer. I am the Chief of the Endocrinology Service at Memorial Sloan-Kettering, which has a tradition of excellence ...
Education and Training
Universidad De Buenos Aires, Facultad De Ciencias Medicas 1973
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Endocrinology, Diabetes and Metabolism
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.
- Frequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours.
- Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas.
- The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.
- The highly malignant phenotype of anaplastic thyroid carcinoma cell lines is recessive.
- Conditional apoptosis induced by oncogenic ras in thyroid cells.
- Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility.
- Genetic markers in thyroid neoplasia.
- Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury.
- IGF-binding protein-4 expression and IGF-binding protein-4 protease activity are regulated coordinately in smooth muscle during postnatal development and after vascular injury.
- Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy.
- Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1.
- Minireview: branded from the start-distinct oncogenic initiating events may determine tumor fate in the thyroid.
- Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
- Perspective: lessons learned from molecular genetic studies of thyroid cancer--insights into pathogenesis and tumor-specific therapeutic targets.
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