Mrs. Leslie Marie Thompson MCD, CCC-SLP
Speech-Language Pathologist
2300 NORTH PARK ST. POCAHONTAS AR, 72455About
Dr. Leslie Thompson is a speech language pathologist practicing in POCAHONTAS, AR. Dr. Thompson specializes in speech, language and swallowing disorders in patients. As a speech language pathologist, Dr. Thompson evaluates, diagnoses and treats patients with communication and swallowing troubles. These conditions may be due to developmental delay, brain injury, hearing loss, autism, stroke or other diseases and injuries. Dr. Thompson helps patients make sounds and improve their voices through various methods. Speech language pathologists also work with patients to strengthen muscles used to speak and swallow, and work with individuals and families to help cope with their conditions.
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Arfaptin 2 regulates the aggregation of mutant huntingtin protein.
- A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.
- Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain.
- Fly models of Huntington's disease.
- Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation.
- Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies.
- Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation.
- Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models.
- Therapeutic application of histone deacetylase inhibitors for central nervous system disorders.
- Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.
- SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.
- Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.
- Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle.
- Identifying polyglutamine protein species in situ that best predict neurodegeneration.
- Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin.
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