Dr. Christopher J. Clarke MD
Cardiologist (Pediatric) | Pediatric Cardiology
100 Hitchcock Way Manchester NH, 03104Rating
3/5
About
Dr. Christopher Clarke is a pediatric cardiologist practicing in Manchester, NH. Dr. Clarke specializes in caring for fetuses, infants, children and adolescents with cardiovascular or cardiac abnormalities. Practiced in both inpatient and outpatient settings, the scope of conditions cared for by pediatric cardiologists is large and includes congenital heart defects, heart muscle disorders, rhythm disturbances and hypertension.
Education and Training
Tufts University School of Medicine 2004
Board Certification
PediatricsAmerican Board of PediatricsABP
DermatologyAmerican Board of DermatologyABD
Provider Details
Expert Publications
- Ice structuring proteins - a new name for antifreeze proteins.
- Expression of IFI 16 in epithelial cells and lymphoid tissues.
- Cytotoxic lymphocytes; instigators of dramatic target cell death.
- A robust model of adjuvant-induced chronic unilateral arthritis in two mouse strains.
- A central role for Bid in granzyme B-induced apoptosis.
- Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2.
- The HIN-200 family: more than interferon-inducible genes?
- An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.
- A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes.
- Norepinephrine and endothelin activate diacylglycerol kinases in caveolae/rafts of rat mesenteric arteries: agonist-specific role of PI3-kinase.
- Cloning and characterisation of Ifi206: a new murine HIN-200 family member.
- Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat.
- Metabolic profiling as a tool for understanding mechanisms of toxicity.
- The role of p202 in regulating hematopoietic cell proliferation and differentiation.
- Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.
- Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist.
- Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat.
- IFNgamma signaling-does it mean JAK-STAT?
- The molecular basis for perforin oligomerization and transmembrane pore assembly.
- The risk of long QT syndrome in the pediatric population.
- Dose response and time course studies on superoxide dismutase as a urinary biomarker of carbon tetrachloride-induced hepatic injury in the Hanover Wistar rat.
- Inducible activation of IFI 16 results in suppression of telomerase activity, growth suppression and induction of cellular senescence.
- Functional crosstalk between type I and II interferon through the regulated expression of STAT1.
- Constitutive type I interferon modulates homeostatic balance through tonic signaling.
- Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation.
- Modulation of antitumour immune responses by intratumoural Stat1 expression.
- Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities.
- Further evidence for the effectiveness of PCV10 against Streptococcus pneumoniae serotype 19A.
- Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses.
- Activation of tissue plasminogen activator by metastasis-inducing S100P protein.
Treatments
- Heart Disease
- Birth Defects
- Congenital Heart Disease
- Pain
Residency
- Children's National Medical Center 2004
Fellowships
- University of Virginia Medical Center, Fellow:Pediatric Cardiology 2007
- University of Virginia Health System, Charlottesville, VA, Pediatric Cardiology 2007
Dr. Christopher J. Clarke MD's Practice location
Practice At 100 Hitchcock Way
100 Hitchcock Way -Manchester, NH 03104Get Direction
Practice At 1215 Lee St
1215 Lee St -Charlottesville, VA 22908Get Direction
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Nearest Hospitals
ELLIOT HOSPITALl
1 ELLIOT WAY MANCHESTER NH 3103PARKLAND MEDICAL CENTERl
1 PARKLAND DRIVE DERRY NH 3038CATHOLIC MEDICAL CENTERl
100 MCGREGOR STREET MANCHESTER NH 3102UNIVERSITY OF VIRGINIA MEDICAL CENTERl
JEFFERSON PARK AVE CHARLOTTESVILLE VA 22908MARTHA JEFFERSON HOSPITALl
500 MARTHA JEFFERSON DRIVE CHARLOTTESVILLE VA 22911