Dr. Christopher J. Clarke MD
Cardiologist (Pediatric) | Pediatric Cardiology100 Hitchcock Way Manchester NH, 03104
Dr. Christopher Clarke is a pediatric cardiologist practicing in Manchester, NH. Dr. Clarke specializes in caring for fetuses, infants, children and adolescents with cardiovascular or cardiac abnormalities. Practiced in both inpatient and outpatient settings, the scope of conditions cared for by pediatric cardiologists is large and includes congenital heart defects, heart muscle disorders, rhythm disturbances and hypertension.
Education and Training
Tufts University School of Medicine 2004
PediatricsAmerican Board of PediatricsABP
DermatologyAmerican Board of DermatologyABD
- Ice structuring proteins - a new name for antifreeze proteins.
- Expression of IFI 16 in epithelial cells and lymphoid tissues.
- Cytotoxic lymphocytes; instigators of dramatic target cell death.
- A robust model of adjuvant-induced chronic unilateral arthritis in two mouse strains.
- A central role for Bid in granzyme B-induced apoptosis.
- Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2.
- The HIN-200 family: more than interferon-inducible genes?
- An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models.
- A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes.
- Norepinephrine and endothelin activate diacylglycerol kinases in caveolae/rafts of rat mesenteric arteries: agonist-specific role of PI3-kinase.
- Cloning and characterisation of Ifi206: a new murine HIN-200 family member.
- Comprehensive characterization of serum clinical chemistry parameters and the identification of urinary superoxide dismutase in a carbon tetrachloride-induced model of hepatic fibrosis in the female Hanover Wistar rat.
- Metabolic profiling as a tool for understanding mechanisms of toxicity.
- The role of p202 in regulating hematopoietic cell proliferation and differentiation.
- Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.
- Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist.
- Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat.
- IFNgamma signaling-does it mean JAK-STAT?
- The molecular basis for perforin oligomerization and transmembrane pore assembly.
- The risk of long QT syndrome in the pediatric population.
- Dose response and time course studies on superoxide dismutase as a urinary biomarker of carbon tetrachloride-induced hepatic injury in the Hanover Wistar rat.
- Inducible activation of IFI 16 results in suppression of telomerase activity, growth suppression and induction of cellular senescence.
- Functional crosstalk between type I and II interferon through the regulated expression of STAT1.
- Constitutive type I interferon modulates homeostatic balance through tonic signaling.
- Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation.
- Modulation of antitumour immune responses by intratumoural Stat1 expression.
- Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities.
- Further evidence for the effectiveness of PCV10 against Streptococcus pneumoniae serotype 19A.
- Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses.
- Activation of tissue plasminogen activator by metastasis-inducing S100P protein.
- Heart Disease
- Birth Defects
- Congenital Heart Disease
- Children's National Medical Center 2004
- University of Virginia Medical Center, Fellow:Pediatric Cardiology 2007
- University of Virginia Health System, Charlottesville, VA, Pediatric Cardiology 2007
Dr. Christopher J. Clarke MD's Practice location
Manchester, NH 03104Get Direction
Charlottesville, VA 22908Get Direction
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Patient Experience with Dr. Clarke
- What is Kawasaki Disease?
Kawasaki disease is a rare childhood disease that causes inflammation of the arteries in the body. The characteristic symptoms of the disease, which is high fever and peeling skin, remains for almost a week. In most cases, it gets back to normal without any major issues. Children will be monitored...
- What Is Duchenne Muscular Dystrophy? Causes, Symptoms, and Treatment
Muscular dystrophies are a group of diseases that make the muscles of the body weaker over a period of time. The muscles become less flexible in this condition. Out of the nine types of muscular dystrophy, Duchenne muscular dystrophy is one of the most common.The main characteristics of this medical...
- Newborn Diagnosis: Tetralogy of Fallot
Tetralogy of FallotTetralogy of Fallot is a congenital heart defect, which affects the heart’s structure, causing blood with low levels of oxygen to circulate throughout the body. Babies born with tetralogy of Fallot tend to have a blue discoloration of the skin due to low oxygen levels in their...
- Congenital Heart Defects
Surgical treatment is the most appropriate option for inborn heart defects, which is not something you can put off.What is a congenital heart defect (CHD)?It is combined damage of the heart muscle in which there are structural deformations and anomalies in the inner chamber partitions, as well as...
- What Is Neonatal Lupus?
Neonatal lupus is a not so common autoimmune disease. It is not true lupus as all the symptoms will completely disappear after 6 months of age. Neonatal lupus is also known by several other terms. The condition is also called as:...
- What Is Progeria?
Progeria or Hutchinson-Gilford progeria syndrome (HGPS), is a rare genetic condition characterized by a rapidly aging appearance in children. Newborns and infants born with this condition typically look healthy and normal, but may physically display characteristic facial features, such as prominent...