Dr. Joseph A Duncan MD
Infectious Disease Specialist | Infectious Disease
101 Manning Dr Chapel Hill NC, 27599About
Dr. Joseph Duncan is an infectious disease specialist practicing in Chapel Hill, NC. Dr. Duncan specializes in infections that are difficult to diagnose or unresponsive to treatments, such as HIV or airborne infections from a foreign country. Infectious disease specialists usually work with conditions that are not treatable by a primary physician but it is important to keep contact with the primary physician in order to receive information about the patients history and for deciding which diagnostic tests are appropriate.
Provider Details
Expert Publications
Data provided by the National Library of Medicine- Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo.
- The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals.
- Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling.
- Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death.
- Rebuilding host-pathogen interaction from the ground up: in vitro reconstitution of the inflammasome.
- ATP binding by monarch-1/NLRP12 is critical for its inhibitory function.
- Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.
- NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways.
- Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells.
- How the noninflammasome NLRs function in the innate immune system.
- Cutting edge: NLRC5-dependent activation of the inflammasome.
- Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome.
- Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.
- Regulation of the subcellular localization of the G-protein subunit regulator GPSM3 through direct association with 14-3-3 protein.
- Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis.
Dr. Joseph A Duncan MD's Practice location
Practice At 101 Manning Dr
101 Manning Dr -Chapel Hill, NC 27599Get Direction
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Nearest Hospitals
DUKE UNIVERSITY HOSPITALl
PO BOX 3814 DUMC ERWIN RD DURHAM NC 27710UNIVERSITY OF NORTH CAROLINA HOSPITALl
101 MANNING DRIVE CHAPEL HILL NC 27514