Dr. Howard Y. Chang MD

Fellowships

• Stanford University School of Medicine,Stanford, Ca, United States   2004

Publications

• tureLandscape and variation of R secondary structure across the human transcriptome.2014
• CELLLong Noncoding Rs: Cellular Address Codes in Development and Disease2013
• TUREControl of somatic tissue differentiation by the long non-coding R TINCR2013
• eLifeA mammalian pseudogene lncR at the interface of inflammation and anti-inflammatory therapeutics.2013
• ture methodsTransposition of tive chromatin for fast and sensitive epigenomic profiling of open chromatin2013
• CELLAging, Rejuvetion, and Epigenetic Reprogramming: Resetting the Aging Clock2012
• TUREA long noncoding R maintains active chromatin to coordite homeotic gene expression2011
• ture protocolsGenome-wide mapping of R structure using nuclease digestion and high-throughput sequencing.2013
• CURRENT OPINION IN CELL BIOLOGYCytotopic localization by long noncoding Rs2013
• CELLThe NeST Long ncR Controls Microbial Susceptibility2013
• JOURL OF INVESTIGATIVE DERMATOLOGYRejuvetion of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment2013
• GENOME RESEARCHSeqFold: Genome-scale reconstruction of R secondary structure2013
• TURE CHEMICAL BIOLOGYR SHAPE alysis in living cells2013
• TURE METHODSSystematic reconstruction of R functiol motifs with high-throughput microfluidics2012
• BMC GENOMICSIdentification of proteins binding coding and non-coding human Rs using protein microarrays2012
• MOLECULAR CELLGenome-wide Measurement of R Folding Energies2012
• PLOS ONEDetection of Long Non-Coding R in Archival Tissue2012
• STEM CELLS AND DEVELOPMENTA Molecular Sigture for Purified Definitive Endoderm Guides Differentiation2012
• CURRENT OPINION IN GENETICS & DEVELOPMENTActive chromatin and noncoding Rs: an intimate relationship2012
• GENES & DEVELOPMENTSuppression of progenitor differentiation requires the long noncoding R ANCR2012
• GENOME BIOLOGYTranscriptiol profiling of long non-coding Rs2012
• ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81Genome Regulation by Long Noncoding Rs2012
• Jourl of visualized experiments : JoVEChromatin isolation by R purification (ChIRP).0
• MOLECULAR CELLGenomic Maps of Long Noncoding R Occupancy Reveal Principles of R-Chromatin Interactions2011
• CELL STEM CELLDirect Lineage Conversion of Termilly Differentiated Hepatocytes to Functiol Neurons2011
• MOLECULAR CELLMolecular Mechanisms of Long Noncoding Rs2011
• JOURL OF CLINICAL INVESTIGATIONDisruption of PPAR gamma2011
• TURE REVIEWS GENETICSUnderstanding the transcriptome through R structure2011
• EMBO REPORTSCrystal structure of the N-termil region of human Ash2L shows a winged2011
• TURE GENETICSExtensive and coordited transcription of noncoding Rs within cell-cycle promoters2011
• TRENDS IN CELL BIOLOGYLong noncoding Rs and human disease2011
• PLOS GENETICSDymic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptiol Networks2011
• EPIGENETICSR templating the epigenome Long noncoding Rs as molecular scaffolds2011
• CANCER RESEARCHLong Intergenic Noncoding Rs: New Links in Cancer Progression2011
• CELL STEM CELLNoncoding R Landmarks of Pluripotency and Reprogramming2010
• JOURL OF CELL BIOLOGYG1 arrest and differentiation can occur independently of Rb family function2010
• TUREGenome-wide measurement of R secondary structure in yeast2010
• R BIOLOGYLong noncoding R in genome regulation Prospects and mechanisms2010
• CELL CYCLEHOTAIR Flight of noncoding Rs in cancer metastasis2010
• SCIENCELong Noncoding R as Modular Scaffold of Histone Modification Complexes2010
• TURELong non-coding R HOTAIR reprograms chromatin state to promote cancer metastasis2010
• JOURL OF INVESTIGATIVE DERMATOLOGYA TGF beta-Responsive Gene Sigture Is Associated with a Subset of Diffuse Scleroderma with2010
• GENES & DEVELOPMENTThe histone demethylase UTX ebles RB-dependent cell fate control2010
• SCIENCEAtomic Demarcation of Cells: Genes to Patterns2009
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMIdentification, molecular characterization2009
• EMBO REPORTSGene dates, parties and galas Symposium on Chromatin Dymics and Higher Order Organization2009
• CELL STEM CELLHierarchical Maintence of MLL Myeloid Leukemia Stem Cells Employs a Transcriptiol Program Shared2009
• EUROPEAN JOURL OF CANCERCombining biological gene expression sigtures in predicting outcome in breast cancer2008
• SCIENCEDeletiol tolerance mediated by extrathymic Aire-expressing cells2008
• JOURL OF CLINICAL INVESTIGATIONMechanisms of an autoimmunity syndrome in mice caused by a domint mutation in Aire2008
• JOURL OF INVESTIGATIVE DERMATOLOGYA systems biology approach to atomic diversity of skin2008
• TURESIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin2008
• GENOME RESEARCHSystematic functiol characterization of cis-regulatory motifs in human core promoters2008
• GENES & DEVELOPMENTA dermal HOX transcriptiol program regulates site-specific epidermal fate2008
• CANCER RESEARCHCSN5 isopeptidase activity links COP9 siglosome activation to breast cancer progression2008
• TUREA histone H3 lysine 27 demethylase regulates animal posterior development2007
• TURE MEDICINETurning skin into embryonic stem cells2007
• CELLFunctiol demarcation of active and silent chromatin domains in human HOX loci by Noncoding Rs2007
• TURE BIOTECHNOLOGYDecoding global gene expression programs in liver cancer by noninvasive imaging2007
• PLOS GENETICSA transcriptiol program mediating entry into cellular quiescence2007
• PLOS GENETICSGenome-wide alysis of KAP1 binding suggests autoregulation of KRAB-ZNFs2007
• JOURL OF INVESTIGATIVE DERMATOLOGYPatterning skin pigmentation via dickkopf2007
• JOURL OF EXPERIMENTAL MEDICINESpontaneous autoimmunity prevented by thymic expression of a single self-antigen2006
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMBone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer2006
• PLOS GENETICSAtomic demarcation by positiol variation in fibroblast gene expression programs2006
• CANCER RESEARCHMYC can induce D breaks in vivo and in vitro independent of reactive oxygen species2006
• CELL CYCLEFrom description to causality - Mechanisms of gene expression sigtures in cancer2006
• TURE GENETICSGenetic regulators of large-scale transcriptiol sigtures in cancer2006
• STEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLSMicroarray alysis of stem cells and differentiation2006
• JOURL OF INVESTIGATIVE DERMATOLOGYLearning more from microarrays: Insights from modules and networks2005
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMRobustness, scalability2005
• PLoS biologyGene expression sigture of fibroblast serum response predicts human cancer progression2004
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMEndothelial cell diversity revealed by global expression profiling2003
• JOURL OF THE AMERICAN ACADEMY OF DERMATOLOGYMyelogenous leukemia cutis resembling stasis dermatitis2003
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMGenomewide view of gene silencing by small interfering Rs2003
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMDiversity, topographic differentiation, and positiol memory in human fibroblasts2002
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMDissecting Fas sigling with an altered-specificity death-domain mutant1999
• SCIENCEActivation of apoptosis sigl regulating kise 1 (ASK1) by the adapter protein Daxx1998
• TUREASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL ICTIVATION OF CALCINEURIN1995
• PROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMCYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B1992
• NatureLandscape and variation of RNA secondary structure across the human transcriptome.2014
• CELLHierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons2013
• CELLLong Noncoding RNAs: Cellular Address Codes in Development and Disease2013
• NATUREControl of somatic tissue differentiation by the long non-coding RNA TINCR2013
• eLifeA mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics.2013
• Nature methodsTransposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin2013
• CELLAging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock2012
• NATUREA long noncoding RNA maintains active chromatin to coordinate homeotic gene expression2011
• Cell reportsTargeted disruption of hotair leads to homeotic transformation and gene derepression.2013
• Nature protocolsGenome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing.2013
• CURRENT OPINION IN CELL BIOLOGYCytotopic localization by long noncoding RNAs2013
• CELLThe NeST Long ncRNA Controls Microbial Susceptibility2013
• JOURNAL OF INVESTIGATIVE DERMATOLOGYRejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment2013
• GENOME RESEARCHSeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput2013
• NATURE CHEMICAL BIOLOGYRNA SHAPE analysis in living cells2013
• NATURE METHODSSystematic reconstruction of RNA functional motifs with high-throughput microfluidics2012
• BMC GENOMICSIdentification of proteins binding coding and non-coding human RNAs using protein microarrays2012
• MOLECULAR CELLGenome-wide Measurement of RNA Folding Energies2012
• PLOS ONEDetection of Long Non-Coding RNA in Archival Tissue2012
• BLOODTranscriptome sequencing in Sezary syndrome identifies Sezary cell2012
• STEM CELLS AND DEVELOPMENTA Molecular Signature for Purified Definitive Endoderm Guides Differentiation2012
• CANCER DISCOVERYThe Transcription Factor ZNF217 Is a Prognostic Biomarker2012
• CURRENT OPINION IN GENETICS & DEVELOPMENTActive chromatin and noncoding RNAs: an intimate relationship2012
• GENES & DEVELOPMENTSuppression of progenitor differentiation requires the long noncoding RNA ANCR2012
• GENOME BIOLOGYTranscriptional profiling of long non-coding RNAs2012
• ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81Genome Regulation by Long Noncoding RNAs2012
• Journal of visualized experiments : JoVEChromatin isolation by RNA purification (ChIRP).0
• LAB ON A CHIPHigh throughput automated chromatin immunoprecipitation as a platform for drug screening2012
• MOLECULAR CELLGenomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions2011
• CELL STEM CELLDirect Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons2011
• MOLECULAR CELLMolecular Mechanisms of Long Noncoding RNAs2011
• JOURNAL OF CLINICAL INVESTIGATIONDisruption of PPAR gamma2011
• NATURE REVIEWS GENETICSUnderstanding the transcriptome through RNA structure2011
• EMBO REPORTSCrystal structure of the N-terminal region of human Ash2L shows a winged2011
• NATURE GENETICSExtensive and coordinated transcription of noncoding RNAs within cell-cycle promoters2011
• TRENDS IN CELL BIOLOGYLong noncoding RNAs and human disease2011
• PLOS GENETICSDynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks2011
• EPIGENETICSRNA templating the epigenome Long noncoding RNAs as molecular scaffolds2011
• CANCER RESEARCHLong Intergenic Noncoding RNAs: New Links in Cancer Progression2011
• CELL STEM CELLNoncoding RNA Landmarks of Pluripotency and Reprogramming2010
• JOURNAL OF CELL BIOLOGYG1 arrest and differentiation can occur independently of Rb family function2010
• NATUREGenome-wide measurement of RNA secondary structure in yeast2010
• RNA BIOLOGYLong noncoding RNA in genome regulation Prospects and mechanisms2010
• CELL CYCLEHOTAIR Flight of noncoding RNAs in cancer metastasis2010
• SCIENCELong Noncoding RNA as Modular Scaffold of Histone Modification Complexes2010
• CELL CYCLETumor suppression by the histone demethylase UTX2010
• NATURELong non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis2010
• JOURNAL OF INVESTIGATIVE DERMATOLOGYA TGF beta-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with2010
• GENES & DEVELOPMENTThe histone demethylase UTX enables RB-dependent cell fate control2010
• SCIENCEAnatomic Demarcation of Cells: Genes to Patterns2009
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OIdentification, molecular characterization2009
• EMBO REPORTSGene dates, parties and galas Symposium on Chromatin Dynamics and Higher Order Organization2009
• CANCER CELLTumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis2009
• CANCER CELLModeling Inducible Human Tissue Neopl2009
• TRENDS IN CELL BIOLOGYRegeneration, repair and remembering identity: the three Rs of Hox gene expression2009
• CELL STEM CELLHierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program2009
• ARTHRITIS AND RHEUMATISMMolecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis2009
• MOLECULAR CELLING4 Mediates Crosstalk between Histone H3 K4 Trimethylation2009
• CELLSIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-kappa B-Dependent Gene Expression2009
• ANNUAL REVIEW OF BIOCHEMISTRYGenome-Wide Views of Chromatin Structure2009
• PLOS ONEGlobal Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory2008
• CELL CYCLEStemness, cancer and cancer stem cells2008
• EUROPEAN JOURNAL OF CANCERCombining biological gene expression signatures in predicting outcome in breast cancer2008
• SCIENCEDeletional tolerance mediated by extrathymic Aire-expressing cells2008
• GENES & DEVELOPMENTControl of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD32008
• JOURNAL OF CLINICAL INVESTIGATIONMechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire2008
• CELL STEM CELLModule map of stem cell genes guides creation of epithelial cancer stem cells2008
• JOURNAL OF INVESTIGATIVE DERMATOLOGYA systems biology approach to anatomic diversity of skin2008
• NATURESIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin2008
• CELL CYCLEReversal of aging by NF kappa B blockade2008
• GENOME RESEARCHSystematic functional characterization of cis-regulatory motifs in human core promoters2008
• GENES & DEVELOPMENTA dermal HOX transcriptional program regulates site-specific epidermal fate2008
• CANCER RESEARCHCSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression2008
• CANCER RESEARCHRevealing targeted therapy for human cancer by gene module maps2008
• GENES & DEVELOPMENTMotif module map reveals enforcement of aging by continual NF-kappa B activity2007
• NATUREA histone H3 lysine 27 demethylase regulates animal posterior development2007
• NATURE MEDICINETurning skin into embryonic stem cells2007
• CELLFunctional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs2007
• NATURE BIOTECHNOLOGYDecoding global gene expression programs in liver cancer by noninvasive imaging2007
• PLOS GENETICSA transcriptional program mediating entry into cellular quiescence2007
• PLOS GENETICSGenome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs2007
• JOURNAL OF INVESTIGATIVE DERMATOLOGYPatterning skin pigmentation via dickkopf2007
• ONCOGENEGSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN2007
• JOURNAL OF EXPERIMENTAL MEDICINESpontaneous autoimmunity prevented by thymic expression of a single self-antigen2006
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OBone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer2006
• PLOS GENETICSAnatomic demarcation by positional variation in fibroblast gene expression programs2006
• CANCER RESEARCHMYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species2006
• CELL CYCLEFrom description to causality - Mechanisms of gene expression signatures in cancer2006
• NATURE GENETICSGenetic regulators of large-scale transcriptional signatures in cancer2006
• STEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLSMicroarray analysis of stem cells and differentiation2006
• BREAST CANCER RESEARCHPredicting a local recurrence after breast-conserving therapy by gene expression profiling2006
• JOURNAL OF INVESTIGATIVE DERMATOLOGYLearning more from microarrays: Insights from modules and networks2005
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ORobustness, scalability2005
• PLoS biologyGene expression signature of fibroblast serum response predicts human cancer progression2004
• ARCHIVES OF DERMATOLOGYKinetics and specificity of Fas ligand induction in toxic epidermal necrolysis2004
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OEndothelial cell diversity revealed by global expression profiling2003
• ARCHIVES OF DERMATOLOGYEruptive xanthomas associated with olanzapine use2003
• JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGYMyelogenous leukemia cutis resembling stasis dermatitis2003
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OGenomewide view of gene silencing by small interfering RNAs2003
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ODiversity, topographic differentiation, and positional memory in human fibroblasts2002
• MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWSProteases for cell suicide: Functions and regulation of caspases2000
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ODissecting Fas signaling with an altered-specificity death-domain mutant1999
• SCIENCEActivation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx1998
• SCIENCEEssential role of CED-4 oligomerization in CED-3 activation and apoptosis1998
• MOLECULAR CELLAutoproteolytic activation of pro-caspases by oligomerization1998
• CELLDaxx, a novel Fas-binding protein that activates JNK and apoptosis1997
• NATUREASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN1995
• MOLECULAR AND CELLULAR BIOLOGYACTIVATION OF CLN1 AND CLN2 G(1) CYCLIN GENE-EXPRESSION BY BCK21995
• PROTEIN SCIENCEACTIVE-SITE MUTANTS OF HUMAN CYCLOPHILIN1992
• PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OCYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B1992

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