Several researches are still studying the direct cause of osteosarcoma, but the following may play a big role in having the disease:
Genetic or familial cases
Having Bone dysplasias
Having Li-Fraumeni syndrome
Having Rothmund-Thomson syndrome
4 Making a Diagnosis
Osteosarcoma diagnosis typically starts with a physical exam followed with X-rays and scans, such as a combination of CT scan, bone scan, PET scan, and MRI.
A typical tell-tale sign in X-rays is the Codman’s triangle, or a subperiosteal lesion that is formed upon raising of the periosteum due to tumor.
To determine if the tumor is malignant or benign, bone biopsy is required. A qualified orthopedic oncologist should perform the biopsy.
Treatment for osteosarcoma usually involves surgery and medication. About 90% of osteosarcoma patients can undergo limb-salvage surgery, but in some cases, infections and other complications may result in a more damaging surgery or amputation.
After tumor-removal surgery, chemotherapy may be required to kill cancer cells and reduce the chance of recurrence.
Standard therapy procedure involves a combination of limb-salvage surgery (or in some cases, amputation) and high doses of several medications, such as:
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