1 What is Fioricet?

Brand: Fioricet

Generic: Butalbital, Acetaminophen and Caffeine

Fioricet is a drug which is used in the relief of tension or muscle contraction headache. This drug is available as a tablet containing 50 mg butalbital, 325 mg acetaminophen, and 40 mg caffeine.


You should read the product information leaflet before using this medication. If you have any questions, ask your doctor or pharmacist.

This medication should be taken by mouth as instructed by your doctor. Do not crush or chew the drug because it may diminish its effects. This medication should be taken with a full glass of water unless your doctor tells you otherwise. You should swallow the drug whole.

Your dosage is based on your medical condition and the way you will respond to treatment. Take this drug regularly to experience the most benefits. You should also take this drug at the same time each day.

If you miss a dose, use it as soon as you remember. Continue to use it as prescribed by your doctor or as stated on the package label.


Fioricet may interact with medications such as:

  • Sodium oxybate
  • Macrolide antibiotics including erythromycin
  • Cimetidine
  • Disulfiram
  • Valproic acid
  • Fluvoxamine
  • MAO inhibitors including isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline or tranylcypromine
  • Isoniazid
  • Lithium
  • Phenothiazines such as chlorpromazine
  • Blood thinners such as warfarin
  • Cyclosporine
  • Doxycycline
  • Estrogen
  • Felodipine
  • Metronidazole
  • Quinidine
  • Theophylline
  • Certain beta blockers such as metoprolol
  • Corticosteroids such as prednisone
  • Antihistamines such as diphenhydramine
  • Anti-seizure drugs such as carbamazepine
  • Medicine for sleep or anxiety such as alprazolam, diazepam or zolpidem
  • Muscle relaxants
  • Narcotic pain relievers such as codeine
  • Psychiatric medicines such as risperidone, amitriptyline or trazodone
  • Contraceptive pills, patches, or ring

Side Effects

There are no side effects known aside from a possible allergic reaction in people who have previous or unknown hypersensitivity to the drug.

Watch out for signs of allergic reactions such as:

  • Rash
  • Itching
  • Swelling


Before taking this medication, tell your doctor or pharmacist if you have the following:

  • Allergy to acetaminophen, caffeine, or butalbital
  • Allergy to other barbiturates such as phenobarbital or xanthine derivatives such as theophylline
  • Severe breathing problems such as bronchopneumonia
  • Porphyria
  • Liver disease
  • Kidney disease
  • Personal or family history of drug or alcohol abuse
  • Psychiatric disorders
  • Gastrointestinal problems
  • Pregnancy or lactation