Inlyta

Inlyta is an antineoplastic agent that is indicated for patients with late stage kidney cancer who have failed with one cancer treatment. 

This product is available in tablet.

Before using Inlyta, you must know all about the risks and complications associated with it.

Tell to your doctor if you are allergic to Axitinib or to any other medications. Safety and effectiveness of this medication have not been established for pediatric population.

There are no specific problems that would limit the usefulness of Axitinib in the elderly.

Pregnancy Category D – Do not use this medication while you are pregnant as it can cause risk to the unborn baby. There are no adequate studies whether Axitinib can pass through breast milk or if it could cause harmful effects to the infant. Discuss with your doctor if you are breastfeeding a baby.

Taking this medicine with any of the following medicines is usually not recommended, but with exception in some cases. Dosage or frequency of one or both of your medicines may be changed if both medicines are prescribed together.

• Atazanavir
• Boceprevir
• Bosentan
• Carbamazepine
• Clarithromycin
• Conivaptan
• Dexamethasone
• Efavirenz
• Etravirine
• Fosphenytoin
• Indinavir
• Itraconazole
• Ketoconazole
• Lopinavir
• Modafinil
• Nafcillin
• Nefazodone
• Nelfinavir
• Phenobarbital
• Phenytoin
• Posaconazole
• Rifabutin
• Rifampin
• Rifapentine
• Ritonavir
• Saquinavir
• St John's Wort
• Telaprevir
• Telithromycin
• Voriconazole

Some medical conditions can interact with this medication. Tell your doctor if you have any of the following conditions:

• Bleeding problems 
• Heart failure
• Hypertension
• Stomach or Bowel fistula
• Thyroid problems
• Blood clotting problems
• Deep vein thrombosis
• Heart attack
• Pulmonary embolism
• Retinal artery or vein occlusion
• Transient ischemic attack
• Liver disease

To use Inlyta properly, you must follow all instructions given by your doctor.

Follow your doctor's exact instructions on when and how to take this medication. This medicine should be taken with whole glass of water. Do not split, crush or chew it. This medicine may be taken with or without food. You should not eat grapefruit or drink grapefruit juice while you are using this medicine. Grapefruit and grapefruit juice may change the amount of the medication that is absorbed in the body.

Initial dose for adult is 5 milligrams twice a day, taken 12 hours apart. Your doctor may adjust your dose as necessary and tolerated.

If you miss a dose of this medicine, take it as soon as possible. However, if it is near for your next dose, skip the missed dose and start again to your regular dosing schedule. Do not take a double dose to make up for a missed one.

Store the medication in a closed container at room temperature, away from heat, moisture, and direct light. Keep out of reach of children. Do not keep expired medications.

Before using Inlyta, there are some precautions you must take.

Your doctor will be checking you regularly to check for the unwanted effects of this medication especially if you have been taking this medication for a long time. Blood tests may be ordered for undesirable effects. Contraceptives must be used to keep you or your partner from getting pregnant. Tell your doctor immediately if you think you have become pregnant while using this medication.

Blood pressure should be checked regularly during therapy with this medicine. Call your doctor right away if you have any of the following symptoms:

• Chest pain or discomfort, numbness or weakness on one side of your body, pain or discomfort in your arms, jaw, back or neck, shortness of breath, trouble talking, or vision changes.
• Rapidly gaining weight, having shortness of breath, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet. These may be symptoms of heart problems or your body keeping too much water.
• Severe stomach burning, cramps, or pains, bloody or black, tarry stools, trouble breathing, heartburn, indigestion, nausea, or vomiting of material that looks like coffee grounds. These could be symptoms of a serious bowel problem.
• Skin rash or any redness, pain, swelling, or blisters on the palms of your hands or the soles of your feet. This medicine may cause a serious skin problem called hand-foot syndrome.
• Headaches, seizures, extreme drowsiness, confusion, or problems with vision while you are using this medicine. This medicine may increase your chance of having a brain condition called reversible posterior leukoencephalopathy syndrome (RPLS).

This medicine may increase your chance of bleeding and cause a delay in wound healing. To reduce the risk of bleeding, you should be cautious when using a regular toothbrush, dental floss, or toothpick. Additionally, avoid contact sports or any activities that may cause injuries.

Tell your doctor that you are using this medicine before undergoing any kind of surgery or emergency treatment. Talk to your doctor if you are planning to take any other medication.

As with many medications, there are several potential side effects associated with Inlyta.

If any of the following side effects occur, check with your doctor right away:

• Abdominal or Stomach pain
• Bleeding gums
• Bloody nose
• Blurred vision
• Cloudy urine
• Confusion
• Constipation
• Coughing up blood
• Decreased urination
• Depressed mood
• Difficult or Labored breathing
• Difficulty with swallowing
• Dizziness
• Dry mouth
• Dry skin and hair
• Fainting
• Feeling cold
• Hair loss
• Hoarseness or Husky voice
• Incoherent speech
• Increased menstrual flow or vaginal bleeding
• Increased urination
• Lightheadedness
• Loss of appetite
• Metallic taste
• Muscle cramps and stiffness
• Muscle weakness
• Nausea
• Nervousness
• Nosebleeds
• Paralysis
• Pounding in the ears
• Rapid breathing
• Red or Black, Tarry stools
• Red or Dark brown urine
• Redness, Swelling, or Pain of the skin
• Scaling of the skin on the hands and feet
• Slow or Fast heartbeat
• Sunken eyes
• Thirst
• Tightness in the chest
• Tingling of the hands and feet
• Ulceration of the skin
• Unusual tiredness or weakness
• Vomiting
• Weight gain or loss
• Wrinkled skin
• Anxiety
• Bleeding from the gums or nose
• Bleeding from the rectum
• Bloody, Black or Tarry stools
• Change in vision
• Chest pain or discomfort
• Extreme drowsiness
• Eye pain
• Heartburn
• Inability to speak
• Indigestion
• Numbness or Tingling in the face, arms, hands, or legs
• Pain in the chest, groin, or legs
• Pain or Discomfort in the arms, jaw, back, or neck
• Pain, Redness, or Swelling in the arm or leg
• Pale skin
• Ringing in the ears
• Seizures
• Sensitivity to heat
• Severe headaches of sudden onset
• Severe stomach pain, cramping, or burning
• Slurred speech
• Sudden loss of coordination
• Sudden onset of slurred speech
• Sudden shortness of breath or troubled breathing
• Sudden vision changes
• Sweating
• Temporary blindness
• Trouble sleeping
• Trouble speaking, thinking, or walking
• Troubled breathing with exertion
• Uncomfortable swelling around the anus
• Unusual bleeding or bruising
• Vomiting of material that looks like coffee grounds
• Weakness in the arm or leg on one side of the body

Less serious side effects:

• Belching
• Change in taste
• Cough
• Cracked lips
• Decreased appetite
• Diarrhea
• Difficulty with moving
• Itching skin or rash
• Joint pain
• Lack or Loss of strength
• Loss of taste
• Muscle aches or pain
• Pain in the arms or legs
• Sore throat
• Sores, Ulcers, or White spots on the lips, tongue, or inside the mouth
• Stomach discomfort or upset
• Swelling or Inflammation of the mouth
• Swollen joints
• Upper stomach pain
• Voice changes
• Burning sensation of the tongue
• Continuous ringing or buzzing or other unexplained noise in the ears
• Flushing or redness of the skin
• Hearing loss
• Thinning of the hair
• Unusually warm skin

Not all side effects are listed above. If you notice any other effects, check with your healthcare professionals.