1 What is Methergine?

Brand: Methergine

Generic: Methylergonovine

Methergine is an ergot alkaloid. It is used to stop bleeding during and after delivery of a baby. It increases contraction of smooth muscles of the uterus which decreases blood loss after delivery.

It may also be used for other conditions as determined by your doctor. It is available in the form of a solution, given only by or under the supervision of your doctor.

2 What to Know Before Using

Before using Methergine, you must know all about the risks and complications associated with it.


Inform your doctor if you are allergic to any food, preservatives, dyes, or had an allergic reaction when you used this drug before.


There are no adequate studies done which prove Methylergonovine’s effects in children. However, safety and efficacy have not been established in children.


This medicine does not cause any different side effects or problem than it does in younger adults. However, it should be used with caution in a patient who has kidney or liver diseases.


It is a category C drug. It may cause harm to an unborn baby. Do not use it during pregnancy.

Breast Feeding

Methylergonovine passes into breast milk. Do not use it if you are breastfeeding. Start breastfeeding 12 hours after your last dose.

Drug Interactions

Methylergonovine may interact with other drugs. Your doctor should be informed of any other medicines which you are taking. He may want to change the dosage or drug.

Some of them are listed below:

  • Itraconazole
  • Ketoconazole
  • Voriconazole
  • Propranolol
  • Clotrimazole
  • Cobicistat
  • Fluoxetine
  • Fluvoxamine
  • Telithromycin
  • Clarithromycin
  • Erythromycin
  • Nefazodone
  • Indinavir
  • Ritonavir
  • Telaprevir
  • Delavirdine
  • Efaviren
  • Triptans
  • Sumatriptan
  • Zileuton
  • Nevirapine
  • Rifampin

Other Medical Conditions

Several other conditions may reduce its effectiveness.

Make sure you inform your doctor of conditions such as:

  • Blood infections (sepsis)
  • History of blood vessel problems (eg, in the brain or heart)
  • Stroke
  • Liver diseases
  • Kidney diseases
  • Heart diseases
  • Hypertension (high blood pressure, especially if it is caused by pregnancy)
  • Eclampsia (seizures in pregnant woman)
  • Smoking
  • Obesity
  • Diabetes
  • High cholesterol
  • If you are taking medicine for angina (chest pain).
  • If you are taking another ergot medicine (eg, dihydroergotamine).

3 Proper Usage

To use Methergine properly, you must follow all instructions given by your doctor. A doctor or a trained health professional will inject this medicine through the needle into your vein or muscle.

It is given after delivery or during the second stage of labor. Avoid taking grapefruit or its juice while using this medicine, as it may increase the amount of Methylergonovine in your blood which may cause some serious side effects.

4 Precautions to Take

Before using Methergine, there are some precautions you must take. Your doctor should check your daily progress at regular visits. He/she may want a blood or urine test to check for unwanted effects.

Do not use this medicine during pregnancy as it may cause uterus contraction and the early birth of your baby. It may cause heart attack. Heart attack risks increases if you have diabetes or have high cholesterol level.

Inform your doctor right away if you have:

  • chest pain or discomfort
  • nausea or vomiting
  • pain or discomfort in the arms, jaw, back, or neck
  • trouble breathing
  • sweating while using this medicine

5 Potential Side Effects

As with many medications, there are several potential side effects associated with Methergine. Some people may experience none or minor side effects.

Consult with your doctor if they become problematic or frequent:

More common are:

  • Abdominal pain
  • Headache
  • Increased blood pressure

Less common are:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.