The two big no-no's to avoid combining with alcohol are opioid substances (such as Vicodin, Percocet, codeine, morphine, OxyContin, fentanyl, heroin, methadone, Suboxone, etc.) and/or benzodiazepine anti-anxiety medications. The latter include lorazepam (Ativan), alprazolam (Xanax), diazepam (Valium), clonazepam (Klonopin) and temazepam (Restoril.) Both benzos and opioids can have a lethal interaction with alcohol and with each other by shutting down the breathing center in the brain.
Jennifer Nagode, M.D., Ph.D.
risk of stomach bleeding
It is recommended to avoid alcohol use with psychotropic medications due to alcohol being a CNS depressant and drug-alcohol interactions. Each individual must weigh risks versus benefits of combining alcohol with medications. It is recommended that Zoloft not be abruptly discontinued due to serotonin withdrawal syndrome. Please consult with the medical provider who is prescribing you Zoloft for additional questions related to alcohol use while taking medications.
Thank you for your question.
Ruchira Densert, MD