“What is the safest drug for depression?”

There are many types of antidepressants, the safest for you is the one that will solve the problem. I suggest using genetic testing to figure out what your body needs and what you will respond to. Using what ever is an expensive and work for someone else may not be the best medicine for you. Most antidepressants are very safe. Good luck.

The antidepressant class of medications ate safe. It is more of which one will be effective for you.

Selective Serotonin Reuptake Inhibitors are some of the safest medications to use for depression. Examples includes Zoloft (sertraline), Celexa (citalopram), Lexapro (Escitalopram), and others

Most modern antidepressants are generally quite safe, however, consideration always has to be given to the person's underlying medical issues, potential for drug-drug interactions with the other medications the person might be taking, and drug-disease interactions. Prior history of adverse reactions would also need to be taken into consideration. Thus, there is no "safest" antidepressant. It really comes down to how the medication interacts with your genes, biology, medical conditions, and other medications.