If you are in significant pain, you must first rule out an insidious ankle fracture. The Ottawa ankle rules are typically used to see if you need an x-ray. If it is indeed just a sprain, ice is helpful in the first 24 hours, then I usually recommend transitioning to heat. Antiinflammatories of choice, whether medical or herbal will help reduce the pain by reducing the swelling, however realize that the inflammatory response is your body's attempt to heal so it's not all bad. Osteopathic manipulation can significant speed up the rate of healing, by helping your body eliminate traumatic strain patterns that have been retained in the fascias surrounding the muscles, bones, ligaments and tendons of the ankle, foot and leg. This can significantly reduce pain, speed healing and improve function.