Gregory J Macdonald MD
Cardiologist | Interventional Cardiology
130 Fisher Rd Building A Suite 2-1 Montpelier VT, 05602About
Dr. Gregory Macdonald is a cardiologist practicing in Montpelier, VT. Dr. Macdonald specializes in diagnosing, monitoring, and treating diseases or conditions of the heart and blood vessels and the cardiovascular system. These conditions include heart attacks, heart murmurs, coronary heart disease, and hypertension. Dr. Macdonald also practices preventative medicine, helping patients maintain a heart-healthy life.
Education and Training
University of Vermont College of Medicine 1976
Board Certification
Internal MedicineAmerican Board of Internal MedicineABIM- Cardiovascular Disease
Provider Details
Expert Publications
Data provided by the National Library of Medicine- A new method for the preparation of silyl enol ethers from carbonyl compounds and (trimethylsilyl)diazomethane in a regiospecific and highly stereoselective manner.
- The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents.
- Identification of small molecule agonists of the motilin receptor.
- Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.
- A decade of progress in the discovery and development of 'atypical' antipsychotics.
- New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.
- Molecular properties affecting fast dissociation from the D2 receptor.
- Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors.
- Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor.
- Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
- Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
- Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.
- Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.
- Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.
- Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.
Treatments
- Heart Disease
- Coronary Artery Disease (cad)
- Pain
- Vascular Disease
Gregory J Macdonald MD's Practice location
Practice At 130 Fisher Rd Building A Suite 2-1
130 Fisher Rd Building A Suite 2-1 -Montpelier, VT 05602Get Direction
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