Laurence Tecott

Areas of expertise and specialization

Faculty Titles & Positions

• Professor Emeritus UCSF 2020 - Present
• Eliaser Endowed Chair UCSF 2006 - 2020

Awards

• NARSAD Scientific Council 2008 NARSAD Scientific Council 
• Sandler Integrative Research Award 2006 Sandler Integrative Research 
• “Freedom to Discover” Award 2005 Bristol-Myers Squibb Foundation 

Professional Memberships

• Society for Neuroscience  
• American College of Neuropsychopharmacology (ACNP)  
• Society for the Study of Ingestive Behavior (SSIB)  
• NARSAD Scientific Council  

Areas of research

Mao R, Page DT, Merzlyak I, Kim C, Tecott LH, Janak PH, Rubenstein JLR, Sur M. Reduced

conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of

interneurons. J Neurodevel Disorders. 1(3): 224-236, 2009 PMID: 19816534.

Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF,

Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G. A serotonin-

dependent mechanism explains the leptin regulation of bone mass, appetite, and energy

expenditure. Cell. 138(5): 976-989, 2009 PMID: 19737523.

Mikulski Z, Zaslona Z, Cakarova L, Hartmann P, Wilhelm J, Tecott LH, Lohmeyer J, Kummer

W. Serotonin activates murine alveolar macrophages through 5-HT2C receptors. Am J Physiol

Lung Cell Mol Physiol. 299(2): L272-80, 2010 PMID: 20495077.

Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R,

Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S,

Tecott LH, Watada H, German MS. Serotonin regulates pancreatic beta cell mass during

pregnancy. Nat Med. 16(7): 804-8, 2010 PMID: 20581837.

Hsu JL, Yu L, Sullivan E, Bowman M, Mistlberger RE, Tecott LH. Enhanced food anticipatory

activity associated with enhanced activation of extrahypothalamic neural pathways in

serotonin2C receptor null mutant mice. PLoS One. 5(7): e11802, 2010 PMID: 20668550.

Honig G, Liou A, Berger M, German MS, Tecott LH. Precise pattern of recombination in

serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line. J Biomed Sci. Oct

2010 PMID: 20950489

Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR,

Karsenty G. CREB mediates brain serotonin regulation of bone mass through its expression in

ventromedial hypothalamic neurons. Genes Dev. 24:2330-42, 2010 PMID: 20952540.

Urban RA, Scherrer G, Goulding EH, Tecott LH, Basbaum AI. Dissociation of mechanical

hypersensitivity from quality of life measures in mouse models of chronic pain. Pain. 152:

990-1000, 2011 PMID:

Dremencov E, Golgering JHA, Hogg S, Tecott LH, Cremers TIFH. The role of 5-HT2C

receptors in the pathophysiology and treatment of depression. In: 5-HT2C Receptors in the

Pathophysiology of CNS Disease. Di Giovanni, Esposito E and Di Matteo (Eds). Human Press,

New York, 249-260, 2011.

Xiong H, Goulding EH, Carlson EJ, Tecott LH, McCulloch CE, Sen S. A flexible estimating

equations approach for mapping function-valued traits. Genetics. 189: 305-316, 2011 PMID:

21705752.

Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N,

Liou A, Tecott LH, Deneris ES, German MS. Convergence of the Insulin and Serotonin

Programs in the Pancreatic-{beta}-Cell. Diabetes. Oct 19, 2011 PMID: 22013016.

Donovan MH, Tecott LH. Serotonin and the regulation of energy balance. Frontiers in

Neuroscience, 7: 36, 2013. PMID: 23543912

Pennanen L, van der Hart M, Yu L, Tecott LH. Impact of 5-HT2C receptors on executive

control processes. Neuropsychopharmacology. 38: 957-67, 2013. PMID: 3629384

Tong CK, Chen J, Cebrian-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, Garcia-

Verdugo JM, Kriegstein A, Alvarez-Buylla A. Axonal control of adult neural stem cell niche.

Cell Stem Cell, 14: 500-11, 2014. PMID: 24561083

Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH. Mice lacking

serotonin 2c receptors have increases affective responses to aversive stimuli. PLOS One,

10(12): e0142906, 2015. PMID: 26630489

Ihle EC, van der Hart M, Jonsma M, Tecott LH, Doupe AJ. Dopamine physiology in the basal

ganglia of male zebra finches during social stimulation. Eur J Neurosci, 12: 1506-14, 2015. PMID:

25872575

Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A,

Tang Y, Regard JB, Sharifnia P, Yu L, Coughlin SR, Conklin BR, Deneris ES, Tecott LH,

German MS. Gai/o-coupled receptor signaling restricts pancreatic B-cell expansion. Proc Natl

Acad Sci USA, 112: 2888-93, 2015. PMID: 25695968

Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell

MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL.

Elucidation of the behavioral program and neuronal network encoded by dorsal raphe

serotonergic neurons. Neuropsychopharmacology 41: 1404-15, 2016. PMID: 26383016

Bonasera SJ, Arikkath J, Boska MD, Chaudoin TR, DeKorver NW, Goulding EH, Hoke TA,

Mojtahedzedah V, Reyelts CD, Sajja B, Schenk AK, Tecott LH, Volden TA. Age-related

changes in cerebellar and hypothalamic function accompany non-microglial immune gene

expression, altered synapse organization, and excitatory amino acid neurotransmitter deficits.

Aging. 8: 2153-2181, 2016. PMID: 27689748

Hillar C, Onnis G, Rhea D, Tecott LH. Active state organization of spontaneous behavioral

patterns. Scientific Reports 8: 1064, 2018. PMID: 29348406

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