Coly-Mycin S

1 What is Coly-Mycin S?

Brand: Coly-Mycin S, Cortisporin TC

Generic: Colistin, neomycin, and hydrocortisone

Colistin, neomycin, and hydrocortisone are combination drugs containing two antibiotics and steroid.

This drug is used for the treatment of infections of the ear canal and to help provide relief from redness, irritation, and discomfort of certain ear problems.

Colistin, neomycin, and hydrocortisone combination require a prescription.

2 What to Know Before Using

Before taking this drug, the risks and benefits for your body should be discussed with your healthcare provider.

Inform your healthcare provider for any allergic reactions to these drugs or any other drugs, foods, dyes, preservatives, or animals.

Carefully read the label of non-prescription drugs for any possible allergic reaction or contraindications.

This drug combination is not expected to cause any different side effects or problems in children and elderly than it does in adults.

It is still unknown whether this drug works exactly the same way in younger adults.

Although there is no specific information comparing the use of colistin, neomycin, and hydrocortisone combination in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Adverse effects have been reported in animals but studies in pregnant women or animals are still inadequate.

Development of any infant risk is still undetermined when taking this drug during breastfeeding.

Discuss with your healthcare provider about the benefits and risks of this drug while breastfeeding.

Drugs should not be taken together to prevent any interactions but in necessary cases inquire your healthcare provider regarding the adjustments in dosage or any other necessary precautions to prevent any unwanted side effects.

Inform your healthcare professional if you are taking any other drugs such as:

  • Amifampridine
  • Rotavirus Vaccine
  • Alcuronium
  • Aldesleukin
  • Atracurium
  • Bupropion
  • Cidofovir
  • Cisatracurium
  • Colistimethate Sodium
  • Dasabuvir
  • Decamethonium
  • Doxacurium
  • Ethacrynic Acid
  • Fazadinium
  • Foscarnet
  • Furosemide
  • Gallamine
  • Hexafluorenium
  • Metocurine
  • Mivacurium
  • Pancuronium
  • Pipecuronium
  • Piperaquine
  • Pixantrone
  • Rapacuronium
  • Rocuronium
  • Sorafenib
  • Topotecan
  • Tubocurarine
  • Vecuronium
  • Alcuronium
  • Atracurium
  • Balofloxacin
  • Besifloxacin
  • Bumetanide
  • Ciprofloxacin
  • Colestipol
  • Enoxacin
  • Fleroxacin
  • Flumequine
  • Gatifloxacin
  • Gemifloxacin
  • Levofloxacin
  • Licorice
  • Lomefloxacin
  • Metocurine
  • Moxifloxacin
  • Nadifloxacin
  • Norfloxacin
  • Ofloxacin
  • Pazufloxacin
  • Pefloxacin
  • Primidone
  • Prulifloxacin
  • Rifapentine
  • Rufloxacin
  • Saiboku-To
  • Sparfloxacin
  • Tosufloxacin

Intake of specific food or using alcohol or tobacco with colistimethate is associated with an increased risk of certain side effects.

Your healthcare professional can give you special instructions about the use of food, alcohol, or tobacco.

Inform your healthcare provider for any other medical problems such as other ear infection or problem, or Herpes simplex viral infection.

3 Proper Usage

Clean your ear canal and dry it with a sterile cotton applicator before using this drug. Do not warm this drug above body temperature to prevent it from breaking down.

Let the infected ear face up by lying down or tilting your head and gently pull the earlobe up and back for adults (down and back for children) to straighten the ear canal.

Drop the drug into the ear canal and keep the ear facing up for about 5 minutes to allow the drug to coat the ear canal.

Your healthcare professional may have inserted a gauze or cotton wick into your ear and may want you to keep the wick moistened with this drug.

Your health care professional also may have other directions for you, such as how long you should keep the wick in your ear or when you should return to your healthcare professional to have the wick replaced.

Check with your healthcare professional if you have any concerns. Refrain from letting the dropper touch any surface and close the container tightly to keep the drug free from germs.

Prolonged use of this drug for 10 is not recommended and can only be done if advised by your healthcare professional. Use this drug for the full time of treatment to ensure complete drug therapy and prevent any relapses.

The dose of this drug will be variable for different patients. The directions on the label or the prescription by your healthcare professional should be followed.

The dosage of this drug you take depends on the medical problem for which you are using this drug. Adults with infections of the ear canal should use four drops of ear suspension in the ear every six to eight hours.

Use up to three drops in the ear for children every six to eight hours. A missed dose should be taken as soon as possible. However, skip the missed dose and go back to your regular dosing schedule if it is almost time for your next dose.

Store the drug in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children.

Dispose any outdated or expired drugs and ask your healthcare professional for the proper disposal of the drugs.

4 Precautions to Take

Consult with your healthcare professional immediately if your symptoms do not improve or become worse within 1 week.

5 Potential Side Effects

Side effects may vary for each individual and prompt medical attention should be given if they occur. Inform you healthcare provider immediately if you experience any unusual symptoms.  

Some side effects may occur that usually do not need medical attention. As your body adjusts to the drug, these side effects may eventually disappear.

Ask your healthcare professional about ways to prevent or reduce some of these side effects. If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional.

If any of the following side effects persists or are inconvenient, or if you notice any other effects, or if you have any questions about them, consult with your health care professional. Report any side effects to the FDA hotline at 1-800-FDA-1088.