1 What is Doribax?

Brand: Doribax

Generic: Doripenem

Brand name:


Doripenem is the best drug in the market for the treating infections caused by bacteria. It works by killing bacteria and preventing their growth at the same time. However, it is not effective in the management of colds, flu or virus infections.

This medicine is given only under prescription by a qualified medical practitioner and by direct supervision of the doctor. It available in various dosage forms.

2 What to Know Before Using

Before one is allowed to use this medicine, there medical practitioners need to make a decision of whether this drugs can be used. This decision needs to take the care of the risk of taking the medicine against the benefits of using the drug. This will inform the decision that both you and your medical practitioner will make.

In considering to use this medicine. The following risks needs to considered. Inform your doctor whether you have ever had any form of allergic reaction to this medicine or any other. Also, inform your doctor if you have any other form of allergies to food, dyes, animals or preservatives. It is important to consider reading the information provided in every label or package carefully.

There are various aspects of this drugs that have not been investigated and understood or remain inconclusive. There are no pediatric studies on the relationship between age and effect of the doripenem injections on the pediatric populations. Similarly, safety and efficacy studies are not established.

Existing data on geriatric appropriateness does not address the geriatric specific problems that provide information on whether to limit the use of doripenem injection among the elderly. However, it suggested that the elderly patients may experience age related kidney problems which need to be managed with caution and may need adjustment of the dose for doripenem injection.

About the effect of doripenem intravenous injection on pregnancy: There is no evidence of harm of the drug to the fetus in animal experiments. However, there are no adequate studies on the pregnant women or animal studies that seek to establish whether there are any adverse effects. Currently, studies done in pregnant women do not demonstrate the risk to the fetus. Similarly, few studies have been performed for determining the risk of the infants in women using this drug while breastfeeding. It is recommended that the benefits for use of the drugs should be weighed against the risks before taking this medication while breastfeeding.

Drug interactions may occur when used together with other drugs such as Probenecid Valproic Acid. When the drugs are prescribed together, the doctor may alter the dosages or how frequent you will be required to take both medicines. Using some drugs around the time of eating may lead to interactions with food.

Use of alcohol and tobacco with certain medicines may also cause drug interaction. It is advisable to use medicines as instructed by your healthcare professional with food, alcohol and tobacco. It is also known that other medical problems can interfere with the forms of treatments and use of medicines.

Inform your doctor of all medical conditions such as allergies to antibiotics, or any other history. Use of this drug may increase the risk of other forms of allergies such as diarrhea. It is advisable to use the drug with caution, conditions may even get worse with kidney disease; it will lead to slow elimination of the drug from the body. Seizures and stroke may also occur in extreme overdosage.

3 Proper Usage

This drug can only be administered with a trained healthcare professional. It is administered through a needle placed in one of your veins. The medicine requires that it is injected slowly and the IV tube may need to be in place for duration of one hour. This will help clear the infection from the body completely.

Doripenem needs to be administered for the full time of treatment even with the improvement of the clinical symptoms after a few days. Skipping the drugs or not completing a dose may decrease the usefulness of the medicine. It also causes the bacteria to develop resistance to the drug.

In this case, doripenem or any other medication may not be able to work effectively in the future. The drugs also work best when the amount of blood or urine is constant. Hence, the drug needs to be administered on a regular basis.

4 Precautions to Take

Close monitoring by the medical doctor is needed when receiving this medicine. This will enable the doctor to evaluate the working of the medicine and to make a decision on whether the patient needs to continue to receive the medicines. The medicines may also lead to allergic reactions which include anaphylaxis.

Anaphylaxis can also be life threatening and may require that one has immediate medical attention. Report any incidence of:

  • Itching
  • Hives
  • Trouble breathing
  • Swallowing
  • Swellings on the face, hands, or mouth after receiving medicine

The drug may cause tremors or seizures while receiving medicines. Any history of stroke or seizures and while one is taking anticonvulsants, they should continue to use the drugs unless instructed otherwise by the medical doctor. Inform your doctor if using sodium valproate or valproic acid (Depakene or Depacon).

Doripenem causes diarrhea and in some cases, it is can be very severe. Sometimes, it comes two months after one has stopped using the medicines. Inform your doctor before taking any medication. Other medicines for treating diarrhea may make the diarrhea worse or even longer. In case of the condition getting worse, always check with your doctor.

5 Potential Side Effects

In case of side effects, medical attention will be required. Check with your doctor or nurse immediately when one or more of the side effects are observed. Some of the symptoms of side effects include:

  • Bluish color diarrhea
  • Pain
  • Tenderness
  • Swellings on the foot or leg pale skin
  • Trouble breathing
  • Bruising
  • Unusual tiredness or weakness
  • Less common abdominal or stomach cramps
  • Blood urine
  • Decreased frequency of urine
  • Fever
  • Increased blood pressure
  • Itching
  • Vaginal pain
  • Loss of appetite
  • Low back pain
  • Nausea
  • Vomiting
  • Sore mouth or tongue swelling as well as fingers or lower legs
  • Thick white vaginal discharge with mild or no odor
  • Watery and severe diarrhea
  • Bloody weight gain and white patches in the mouth or tough
  • Blistering
  • Peeling or loosening of the skin
  • Chills
  • Cough
  • Difficulty in swallowing or sore throat dizziness fast heartbeat
  • Itching joints and muscle pain loss of bladder control


  • Muscle pain
  • Loss of bladder control
  • Jerking of extremities
  • Puffiness or swelling of the eyelids, face, lips or tongue
  • Red skins
  • Lesions, often coming with a red center
  • Irritated eyes skin rash or hive sores
  • Ulcers or white spots

However, some of the side effects may disappear when the body adjusts to treatments when the body adjusts to the medicines. Some of the side effects can be managed when one visits a healthcare professional. Some side effects as headache may also occur. Call your doctor for medical advice about the side effects. Reports on the side effects can also be made directly to the FDA.

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